The chemotherapeutic agents XK469 (2-{4-[(7-Chloro-2- Quinoxalinyl)oxy] phenoxy}propionic acid) and SH80 (2-{4- [(7-bromo-2-quinolinyl)oxy]phenoxy} propionic acid) inhibit cytokinesis and promote polyploidy and induce senescence

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 3, 2009, Pages 796-806

  Reiners Jr , John J ^a   Kleinman, Miriam ^a   Joiakim, Aby ^a   Mathieu, Patricia A ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [(7 BROMO 2 QUINOLINYL)OXY]PHENOXY]PROPIONIC ACID; 2 [4 [(7 CHLORO 2 QUINOXALINYL)OXY]PHENOXY]PROPIONIC ACID; BETA GALACTOSIDASE; CYCLIN D1; CYCLIN E; ETHYL 2 [4 [(6 CHLORO 2 QUINOXALINYL)OXY]PHENOXY]PROPIONATE; MICROTUBULE ASSOCIATED PROTEIN; PHOSPHATIDYLETHANOLAMINE; PROCASPASE 3; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; QUINOLINE DERIVATIVE; QUINOXALINE DERIVATIVE; SH 80; UNCLASSIFIED DRUG; XK 469; XK 472;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CYTOKINESIS; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG MECHANISM; MAMMAL CELL; MOUSE; MULTINUCLEAR CELL; NONHUMAN; POLYPLOIDY; PRIORITY JOURNAL; SENESCENCE;

ANIMALS; AUTOPHAGY; CELL AGING; CELL DIVISION; CELL LINE; CELLS, CULTURED; CYTOKINESIS; FLOW CYTOMETRY; MICE; PEPTIDE HYDROLASES; POLYPLOIDY; PROPIONIC ACIDS; QUINOXALINES;

EID: 62549093591     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.144808     Document Type: Article

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