A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 2234-2238

  Anizon, Fabrice ^a   Golsteyn, Roy M ^b   Léonce, Stéphane ^b   Pfeiffer, Bruno ^b   Prudhomme, Michelle ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Antitumor agents; Chk1 inhibitors; Indolocarbazoles; Rebeccamycin; Staurosporine

Indexed keywords

CARBOHYDRATE; INDOLE; NITROGEN; REBECCAMYCIN;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; IC 50;

ANIMALS; CARBAZOLES; CARBOHYDRATES; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; PROTEIN KINASE INHIBITORS; PROTEIN KINASES;

EID: 62549091422     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.05.023     Document Type: Article

References (18)

1. Bush J.A., Long B.H., Catino J.J., Bradner W.T., and Tomita K. J. Antibiot. 40 (1987) 668-678
2. Rodrigues Pereira E., Belin L., Sancelme M., Prudhomme M., Ollier M., Rapp M., Sevère D., Riou J.F., Fabbro D., and Meyer T. J. Med. Chem. 39 (1996) 4471-4477
3. Bailly C., Riou J.F., Colson P., Houssier C., Rodrigues Pereira E., and Prudhomme M. Biochemistry 36 (1997) 3917-3929
4. Bailly C. Curr. Med. Chem. 6 (1999) 39-51
5. Prudhomme M. Curr. Med. Chem. 7 (2000) 1189-1212
6. Moreau P., Anizon F., Sancelme M., Prudhomme M., Bailly C., Carrasco C., Ollier M., Sevère D., Riou J.F., Fabbro D., Meyer T., and Aubertin A.-M. J. Med. Chem. 41 (1998) 1631-1640
7. Moreau P., Anizon F., Sancelme M., Prudhomme M., Bailly C., Sevère D., Riou J.F., Fabbro D., Meyer T., and Aubertin A.-M. J. Med. Chem. 42 (1999) 584-592
8. Moreau P., Anizon F., Sancelme M., Prudhomme M., Sevère D., Riou J.F., Goossens J.-F., Hénichart J.-P., Bailly C., Labourier E., Tazi J., Fabbro D., Meyer T., and Aubertin A.-M. J. Med. Chem. 42 (1999) 1816-1822
9. Long B.H., Rose W.C., Vyas D.M., Matson J.A., and Forenza S. Curr. Med. Chem. Anticancer Agents 2 (2002) 255-266
10. Anizon F., Belin L., Moreau P., Sancelme M., Voldoire A., Prudhomme M., Ollier M., Sevère D., Riou J.F., Bailly C., Fabbro D., and Meyer T. J. Med. Chem. 40 (1997) 3456-3465
11. Marminon C., Pierré A., Pfeiffer B., Pérez V., Léonce S., Renard P., and Prudhomme M. Bioorg. Med. Chem. 11 (2003) 679-687
12. Marminon C., Pierré A., Pfeiffer B., Pérez V., Léonce S., Joubert A., Bailly C., Renard P., Hickman J., and Prudhomme M. J. Med. Chem. 46 (2003) 609-622
13. Anizon F., Moreau P., Sancelme M., Voldoire A., Prudhomme M., Ollier M., Sevère D., Riou J.F., Bailly C., Fabbro D., Meyer T., and Aubertin A.-M. Bioorg. Med. Chem. 6 (1998) 1597-1604
14. Marminon C., Anizon F., Moreau P., Léonce S., Pierré A., Pfeiffer B., Renard P., and Prudhomme M. J. Med. Chem. 45 (2002) 1330-1339
15. Zhao B., Bower M.J., McDevitt P.J., Zhao H., Davis S.T., Johanson K.O., Green S.M., Concha N.O., and Zhou B.B.S. J. Biol. Chem. 277 (2002) 46609-46615
16. Bartek J., and Lukas J. Curr. Opin. Cell Biol. 19 (2007) 238-245
17. Janetka J.W., Ashwell S., Zabludoff S., and Lyne P. Curr. Opin. Drug Discov. Devel. 10 (2007) 473-486
18. Davies S.P., Reddy H., Caivano M., and Cohen P. Biochem. J. 351 (2000) 95-105