Plasmodium chabaudi chabaudi and p. falciparum: Inhibition of aminopeptidase anti parasite growth by bestatin and nitrobestatin

Parasitology Research

Volumn 84, Issue 7, 1998, Pages 552-558

  Nankya Kitaka, M F ^a   Curley, G P ^a   Gavigan, C S ^b   Bell, A ^b   Dalton, J P ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

AMASTATIN; AMINOPEPTIDASE; ANTIMALARIAL AGENT; BESTATIN; BESTATIN DERIVATIVE; CHLOROQUINE; EPIAMASTATIN; NITROBESTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM CHABAUDI; PRIORITY JOURNAL;

ANIMALS; ANTIMALARIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; LEUCINE; LEUCYL AMINOPEPTIDASE; MICE; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PROTEASE INHIBITORS;

ANIMALIA; PLASMODIUM CHABAUDI CHABAUDI; PLASMODIUM FALCIPARUM; PROTOZOA; RODENTIA;

EID: 0031878901     PISSN: 00443255     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004360050447     Document Type: Article

References (27)

1. Bailly E, Jambou R, Savel J, Jaureguiberry G (1992) Plasmodium falciparum: differential sensitivity in vitro to E-64 (cysteine protease inhibitor) and pepstatin A (aspartyl protease inhibitor). J Protozool 39: 593-599.
2. Bell A, Wernli B, Franklin RM (1993) Effects of microtubule inhibitors on protein synthesis in Plasmodium falciparum. Parasitol Res 79: 146-152
3. Charet P, Aissi E, Maurois P, Bouquelet S, Biguet J (1980) Aminopeptidase in rodent Plasmodium. Comp Biochem Physiol [B] 65: 519-524
4. Curley GP, O'Donovan SM, McNally J, Mullally M, O'Hara H, Troy A, O'Callaghan S-A, Dalton JP (1994) Aminopeptidases from Plasmodium falciparum, Plasmodium chabaudi chabaudi and Plasmodium berghei. J Euk Microbiol 41: 119-123.
5. Dixon M (1953) The determination of enzyme inhibitor constants. Biochem J 55: 170-171
6. Francis SE, Gluzman, IY, Oksman A, Knickerbocker A, Mueller R, Bryant ML, Sherman DR, Russell DG, Goldberg DE (1994) Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase. EMBO J 13: 306-317
7. Goldberg DE, Slater AFG (1992) The pathway of haemoglobin degradation in malaria parasites. Parasitol Today 8: 280-283.
8. Goldberg DE, Slater AFG, Beavis R, Chait B, Cerami A, Henderson GB (1991) Haemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease. J Exp Med 87: 2931-2935
9. Gyang FN, Poole P, Trager W (1982) Peptidases from Plasmodium falciparum cultured in vitro. Mol Biochem Parasitol 5: 263-273
10. Kolakovich KA, Gluzman IY, Duffin KL, Goldberg DE (1997) Generation of haemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production. Mol Biochem Parasitol 87: 123-135
11. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
12. Lambros C, Vanderberg JP (1979) Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65: 418-420
13. Makler MT, Ries JM, Williams JA, Bancroft JE, Piper RC, Gibbons BL, Hinrichs DJ (1993) Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. Am J Trop Med Hyg 48: 739-741
14. McNally J, O' Donovan SM, Dalton JP (1992) An improved medium for Plasmodium chabaudi in vitro erythrocyte invasion assays. Parasitology 105: 355-362
15. O'Donovan SM, Dalton JP (1993) Plasmodium berghei and Plasmodium chabaudi chabaudi: development of simple in vitro erythrocyte invasion assays. J Euk Microbiol 40: 152-154
16. Olliaro PL, Goldberg DE (1995) The Plasmodium digestive vacuole: metabolic headquarters and choice drug target. Parasitol Today 11: 294-298
17. Rosenthal PJ (1995) Effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites. Exp Parasitol 88: 272-281
18. Rosenthal PJ, McKerrow JH, Aikawa M, Nagasawa H, Leech JH (1988) A malarial cysteine proteinase is necessary for haemoglobin degradation by Plasmodium falciparum. J Clin Invest 82: 1560-1566
19. Rosenthal PJ, Wollich WS, Palmer JT, Rasnick D (1991) Anti-malarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase. J Clin Invest 88: 1467-1472
20. Rosenthal PJ, Lee GK, Smith RE (1993) Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria. J Clin Invest 91: 1052-1056
21. Sakakariba T, Ito K, Irie Y, Hagiwara T, Sakai Y, Hayashi M, Kishi H, Sakamoto M, Suziki M (1983) Toxicological studies on bestatin. 1. Acute toxicity test in mice, rats, and dogs. J Antibiot (Tokyo) 36: 2971-2984
22. Salas F, Fichman J, Lee GK, Scott MD, Rosenthal PJ (1995) Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase. Infect Immun 63: 2120-2125
23. 14C-amino acids by malaria (Plasmodium lophurae). IV. In vivo utilization of host cell haemoglobin. Int J Biochem 1: 635-637
24. Slomianny C, Charet P, Prensier G (1983) Ultrastructural localization of enzymes involved in the feeding process in Plasmodium chabaudi and Babesia hylomysci. J Parasitol 30: 376-382
25. Taylor A (1993) Aminopeptidases: structure and function. FASEB J 7: 290-298
26. Vander Jagt DL, Baack BR, Hunsaker LA (1984) Purification and characterisation of an aminopeptidase from Plasmodium falciparum. Mol Biochem Parasitol 10: 45-54
27. Vander Jagt DL, Hunsaker LA, Campos NM (1987) Comparison of the proteases from chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. Biochem Pharmacol 36: 3285-3291