Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase: A protease involved in amino acid regulation with potential for antimalarial drug development

Journal of Biological Chemistry

Volumn 282, Issue 3, 2007, Pages 2069-2080

  Stack, Colin M ^a   Lowther, Jonathan ^a   Cunningham, Eithne ^b   Donnelly, Sheila ^a   Gardiner, Donald L ^c   Trenholme, Katharine R ^c   Skinner Adams, Tina S ^c,d   Teuscher, Franka ^c   Grembecka, Jolanta ^e   Mucha, Artur ^f   Kafarski, Pawel ^f   Lua, Linda ^d   Bell, Angus ^b   Dalton, John P ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e UNIVERSITY OF VIRGINIA   (United States)

^f WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL DRUG; CATABOLISM; CYTOSOLIC COMPARTMENT; ERYTHROCYTIC MALARIA PARASITES; GREEN FLUORESCENT PROTEIN; HEMOGLOBIN DEGRADATION; HYDROPHOBIC AMINO ACIDS; IMMUNOHISTOCHEMICAL METHODS; PROTEIN SYNTHESIS;

AMINO ACIDS; DRUG PRODUCTS; ENZYME INHIBITION; HEMOGLOBIN; IMMUNOLOGY; MALARIA CONTROL; PH EFFECTS; SYNTHESIS (CHEMICAL);

ENZYME KINETICS;

AMINO ACID; ANTIMALARIAL AGENT; BESTATIN; CYTOSOL AMINOPEPTIDASE; DIPEPTIDE DERIVATIVE; GREEN FLUORESCENT PROTEIN; PROTEINASE INHIBITOR; PROTOZOAL PROTEIN; ION; LEUCINE; RECOMBINANT PROTEIN;

ALKALINITY; AMINO TERMINAL SEQUENCE; ANTIMALARIAL ACTIVITY; ARTICLE; CELL CYCLE; CELL MATURATION; CONTROLLED STUDY; DEGRADATION KINETICS; DEVELOPMENTAL STABILITY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ERYTHROCYTE; HEMOGLOBIN DETERMINATION; HYDROPHOBICITY; IMMUNOHISTOCHEMISTRY; INSECT CELL; MEROZOITE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; TROPHOZOITE; UPREGULATION; ANIMAL; CHEMISTRY; CYTOSOL; ENZYMOLOGY; KINETICS; METABOLISM; PH; PHYLOGENY; PHYSIOLOGY; PLASMID;

HEXAPODA; PLASMODIUM FALCIPARUM;

AMINO ACIDS; ANIMALS; ANTIMALARIALS; CYTOSOL; HYDROGEN-ION CONCENTRATION; IMMUNOHISTOCHEMISTRY; IONS; KINETICS; LEUCINE; LEUCYL AMINOPEPTIDASE; MEROZOITES; PHYLOGENY; PLASMIDS; PLASMODIUM FALCIPARUM; RECOMBINANT PROTEINS; TROPHOZOITES;

EID: 33847281493     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609251200     Document Type: Article

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