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Volumn 81, Issue 6, 2007, Pages 817-820

Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2D6; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE;

EID: 34249034315     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/sj.clpt.6100125     Document Type: Article
Times cited : (19)

References (14)
  • 1
    • 33645109079 scopus 로고    scopus 로고
    • CYP2D6*36 gene arrangements within the CYP2D6 locus: Association of CYP2D6*36 with poor metabolizer status
    • Gaedigk, A., Alander, S.W., Bradford, L.D. & Leeder, J.S. CYP2D6*36 gene arrangements within the CYP2D6 locus: association of CYP2D6*36 with poor metabolizer status. Drug Metab. Dispos. 34, 563-569 (2006).
    • (2006) Drug Metab. Dispos , vol.34 , pp. 563-569
    • Gaedigk, A.1    Alander, S.W.2    Bradford, L.D.3    Leeder, J.S.4
  • 2
    • 33846643134 scopus 로고    scopus 로고
    • Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: Characterization of gene duplication events
    • Gaedigk, A. et al. Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events. Clin. Pharmacol. Ther. 81, 242-251 (2007).
    • (2007) Clin. Pharmacol. Ther , vol.81 , pp. 242-251
    • Gaedigk, A.1
  • 3
    • 33746041490 scopus 로고    scopus 로고
    • New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes
    • Li, L. et al. New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes. Drug Metab. Dispos. 34, 1411-1416 (2006).
    • (2006) Drug Metab. Dispos , vol.34 , pp. 1411-1416
    • Li, L.1
  • 4
    • 0036339071 scopus 로고    scopus 로고
    • Unique CYP2D6 activity distribution and genotype-phenotype discordance in African Americans
    • Gaedigk, A., Bradford, L.D., Marcucci, K.A. & Leeder, J.S. Unique CYP2D6 activity distribution and genotype-phenotype discordance in African Americans. Clin. Pharmacol. Ther. 72, 76-89 (2002).
    • (2002) Clin. Pharmacol. Ther , vol.72 , pp. 76-89
    • Gaedigk, A.1    Bradford, L.D.2    Marcucci, K.A.3    Leeder, J.S.4
  • 5
    • 0038548107 scopus 로고    scopus 로고
    • Discovery of a novel non-functional cytochrome P4502D6 allele, CYP2D6*42, in African Americans
    • Gaedigk, A., Ndjountsche, L., Gaedigk, R., Bradford, L.D. & Leeder, J.S. Discovery of a novel non-functional cytochrome P4502D6 allele, CYP2D6*42, in African Americans. Clin. Pharmacol. Ther. 73, 575-576 (2003).
    • (2003) Clin. Pharmacol. Ther , vol.73 , pp. 575-576
    • Gaedigk, A.1    Ndjountsche, L.2    Gaedigk, R.3    Bradford, L.D.4    Leeder, J.S.5
  • 6
    • 0032963135 scopus 로고    scopus 로고
    • Wang, S.-L., Lai, M.-D. & Huang, J.-D. G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. Drug Metab. Dispos. 27, 385-388 (1999).
    • Wang, S.-L., Lai, M.-D. & Huang, J.-D. G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. Drug Metab. Dispos. 27, 385-388 (1999).
  • 7
    • 0036089729 scopus 로고    scopus 로고
    • Single-step assays to analyze CYP2D6 gene polymorphisms in Asians: Allele frequencies and a novel *14b allele in mainland Chinese
    • Ji, L. et al. Single-step assays to analyze CYP2D6 gene polymorphisms in Asians: allele frequencies and a novel *14b allele in mainland Chinese. Clin. Chem. 48, 983-988 (2002).
    • (2002) Clin. Chem , vol.48 , pp. 983-988
    • Ji, L.1
  • 8
    • 10344266435 scopus 로고    scopus 로고
    • A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype
    • Yokoi, T. et al. A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype. Pharmacogenetics 6, 395-401 (1996).
    • (1996) Pharmacogenetics , vol.6 , pp. 395-401
    • Yokoi, T.1
  • 9
    • 85009589901 scopus 로고    scopus 로고
    • Two novel haplotypes of CYP2D6 gene in a Japanese population
    • Yamazaki, H. et al. Two novel haplotypes of CYP2D6 gene in a Japanese population. Drug Metab. Pharmacokinet. 18, 269-271 (2003).
    • (2003) Drug Metab. Pharmacokinet , vol.18 , pp. 269-271
    • Yamazaki, H.1
  • 11
    • 20744455857 scopus 로고    scopus 로고
    • Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans
    • Gaedigk, A. et al. Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans. Pharmacogenomics J. 5, 173-182 (2005).
    • (2005) Pharmacogenomics J , vol.5 , pp. 173-182
    • Gaedigk, A.1
  • 12
    • 13944266054 scopus 로고    scopus 로고
    • Limited association of the 2988G>A single nucleotide polymorphism with CYP2D6*41 in black subjects
    • Gaedigk, A., Ndjountsché, L., Leeder, J.S. & Bradford, L.D. Limited association of the 2988G>A single nucleotide polymorphism with CYP2D6*41 in black subjects. Clin. Pharmacol. Ther. 77, 228-230 (2005).
    • (2005) Clin. Pharmacol. Ther , vol.77 , pp. 228-230
    • Gaedigk, A.1    Ndjountsché, L.2    Leeder, J.S.3    Bradford, L.D.4
  • 13
    • 0033461165 scopus 로고    scopus 로고
    • Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data
    • Gaedigk, A., Gotschall, R.R., Forbes, N.S., Simon, S.D. & Leeder, J.S. Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics 9, 669-682 (1999).
    • (1999) Pharmacogenetics , vol.9 , pp. 669-682
    • Gaedigk, A.1    Gotschall, R.R.2    Forbes, N.S.3    Simon, S.D.4    Leeder, J.S.5
  • 14
    • 34249015426 scopus 로고    scopus 로고
    • Chronic intermittent nocturnal hypoxemia alters activirties of hepatic cytochrome P4501A2 (CYP1A2), N- acetyltransferase 2 (NAT2), and xanthine oxidase (XO) in children with obstructive sleep apnea (OSA)
    • Kennedy, M.-J. et al. Chronic intermittent nocturnal hypoxemia alters activirties of hepatic cytochrome P4501A2 (CYP1A2), N- acetyltransferase 2 (NAT2), and xanthine oxidase (XO) in children with obstructive sleep apnea (OSA). Clin. Pharmacol. Ther. 79, 33 (2006).
    • (2006) Clin. Pharmacol. Ther , vol.79 , pp. 33
    • Kennedy, M.-J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.