The leader peptide is essential for the post-translational modification of the DNA-gyrase inhibitor microcin B17

Molecular Microbiology

Volumn 23, Issue 1, 1997, Pages 161-168

  Madison, Lara L ^a   Vivas, Eugenio I ^a,b   Li, Yue Ming ^a   Walsh, Christopher T ^a   Kolter, Roberto ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b FACULTAD DE CIENCIAS   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ENZYME INHIBITOR; GYRASE INHIBITOR; MICROCIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROCESSING; RNA TRANSLATION;

EID: 0031023072     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1997.2041565.x     Document Type: Article

References (31)

1. Bayer, A., Freund, S., Nicholson, G., and Jung, G. (1993) Posttranslational backbone modifications in the ribosomal biosynthesis of the glycine rich antibiotic microcin B17. Angew Chem Int Ed Engl 32: 1336-1339.
2. 70. J Bacteriol 173: 4482-4492.
3. Chakicherla, A., and Hansen, J.N. (1995) Role of the leader and structural regions of prelantibiotic peptides as assessed by expressing nisin-subtilin chimeras in Bacillus subtilis 168, and characterization of their physical, chemical, and antimicrobial properties. J Biol Chem 270: 23533-23539.
4. Davis, R.W., Botstein, D., and Roth, J.R. (1980) A Manual for Genetic Engineering: Advanced Bacterial Genetics. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
5. Fath, M.J., and Kolter, R. (1993) ABC transporters: bacterial exporters. Microbiol Rev 57: 995-1017.
6. Garrido, M.C., Herrero, M., Kolter, R., and Moreno, F. (1988) The export of the DNA replication inhibitor microcin B17 provides immunity for the host cell. EMBO J 7: 1853-1862.
7. Gilson, L., Mahanty, H.K., and Kolter, R. (1987) Four plasmid genes are required for colicin V synthesis, export, and immunity. J Bacteriol 169: 2466-2470.
8. Gilson, L., Mahanty, H.K., and Kolter, R. (1990) Genetic analysis of an MDR-like export system: the secretion of colicin V. EMBO J 9: 3875-3884.
9. Harlow, E., and Lane, D. (1988) Antibodies: A laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
10. Håvarstein, L.S., Diep, D.B., and Nes, I.F. (1995) A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export. Mol Microbiol 16: 229-240.
11. Ingram, L.C. (1969) Synthesis of the antibiotic nisin: formation of lanthionine and β-methyl-lanthionine. Biochem Biophys Acta 184: 216-219.
12. Jack, R.W., Tagg, J.R., and Ray, B. (1995) Bacteriocins of Gram-Postive bacteria. Microbiol Rev 59: 171-200.
13. Jorgensen, M.J., Cantor, A.B., Furie, B.C., Brown, C.L., Shoemaker, C.B., and Furie, B. (1987) Recognition site directing vitamin K-dependent γ-carboxylation resides on the pro-peptide of Factor IX. Cell 48: 185-191.
14. Jung, G. (1991) Lantibiotics - ribosomally synthesized biologically active polypeptides containing sulfide bridges and alpha-beta-didehydroamino acids. Angew Chem Int Ed Engl 30: 1051-. 1068.
15. Kolter, R., and Moreno, F. (1992) Genetics of ribosomally synthesized peptide antibiotics. Annu Rev Microbiol 46: 141-163.
16. Kuipers, O.P., Rollema, H.S., de Vos, W.M., and Siezen, R.J. (1993) Biosynthesis and secretion of a precursor of nisin Z by Lactococcus lactis, directed by the leader peptide of the homologous lantibiotic subtilin from Bacillus subtilus. FEBS Lett 330: 23-27.
17. Li, Y.-M., Milne, J.C., Madison, L.L., Kolter, R., and Walsh, C.T. (1996) From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 Synthase. Science 274: 1188-1193.
18. Maniatis, T., Fritsch, E.F., and Sambrook, J. (1982) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
19. Miller, C.G. (1996) Protein degradation and proteolytic modification. In Esherichia coli and Salmonella: Cellular and Molecular Biology. Vol. 1. Neidhardt, F.C., Curtiss, R., Ingraham,. J.L., Lin, E.C.C., Low, K.B., Magasanik, B., Reznikoff, W.S., Riley, M., Schaechter, M., and Umbarger, H.E. (eds). Washington, DC: American Society for Microbiology Press, pp. 938-954.
20. Miller, J.H. (1972) Experiments in Molecular Genetics. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
21. Murphy, C.K., and Beckwith, J. (1996) Export of proteins to the cell envelope. In Esherichia coli and Salmonella: Cellular and Molecular Biology. Vol. 1. Neidhardt, F.C., Curtiss, R.,. Ingraham, J.L., Lin, E.C.C., Low, K.B., Magasanik, B., Reznikoff, W.S., Riley, M., Schaechter, M., and Umbarger, H.E. (eds). Washington, DC: American Society for Microbiology Press, pp. 938-954.
22. Ringquist, S., Shinedling, S., Barrick, D., Green, L., Binkley, J., Stormo, G.D., and Gold, L. (1992) Translation initiation in Escherichia coli: sequences within the ribosomal binding site. Mol Microbiol 6: 1219-1229.
23. Sahl, H.-J., Jack, R.W., and Bierbaum, G. (1995) Biosynthesis and biological activities of lantibiotics with unique post-translational modifications. Eur J Biochem 230: 827-853.
24. San Millán, J.L., Kolter, R., and Moreno, F. (1985) Plasmid genes required for microcin B17 production. J Bacteriol 163: 1016-1020.
25. Schägger, H., and von Jagow, G. (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range of 1-100kDa. Anal Biochem 166: 368-379.
26. Steers, Jr, E., Cuatrecasas, P., and Pollard, H.B. (1971) Purification of β-galactosidase from Escherichia coli by affinity chromatography. J Biol Chem 246: 196-200.
27. Taura, T., Baba, T., Akiyama, Y., and Ito, K. (1993) Determinants of the quantity of the stable SecY complex in the Esherichia coli cell. J Bacteriol 175: 7771-7775.
28. Ulrich, M.M.W., Furie, B., Jacobs, M.R., Vermeer, C., and Furie, B.C. (1988) Vitamin K-dependent carboxylation. J Biol Chem 263: 9697-9702.
29. Wandersman, C. (1996) Secretion across the bacterial outer membrane. In Esherichia coli and Salmonella: Cellular and Molecular Biology. Vol. 1. Neidhardt, F.C., Curtiss, R., Ingraham, J.L., Lin, E.C.C., Low, K.B., Magasanik, B., Reznikoff, W.S., Riley, M., Schaechter, M., and Umbarger, H.E. (eds). Washington, DC: American Society for Microbiology Press, pp. 955-966.
30. Yorgey, P., Davagnino, J., and Kolter, R. (1993) The maturation pathway of microcin B17, a peptide inhibitor of DNA gyrase. Mol Microbiol 9: 897-905.
31. Yorgey, P., Lee, J., Kördel, J., Vivas, E., Warner, P., Jebaratnam, P., and Kolter, R. (1994) Post-translational modifications in microcin B17 define an additional class of DNA gyrase inhibitor. Proc Natl Acad Sci USA 91: 4519-4523.