Increased risk for fetal loss in carriers of the factor V Leiden mutation

Annals of Internal Medicine

Volumn 130, Issue 9, 1999, Pages 736-739

  Meinardi, Johan R ^a   Middeldorp, Saskia ^b   De Kam, Pieter J ^a   Koopman, Maria M W ^b   Van Pampus, Elisabeth C M ^c   Hamulyák, Karly ^c   Prins, Martin H ^b   Büller, Harry R ^b   Van Der Meer, Jan ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN;

ADULT; ARTICLE; FEMALE; FETUS; FETUS WASTAGE; GENE MUTATION; GENETIC RISK; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SPONTANEOUS ABORTION; STATISTICAL ANALYSIS; STILLBIRTH;

EID: 0033522394     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-130-9-199905040-00013     Document Type: Article

References (17)

1. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994;369:64-7.
2. Voorberg J, Roelse J, Koopman R, Büller H, Berends F, ten Cate JW, et al. Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V. Lancet. 1994;343:1535-6.
3. Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med. 1995;332:912-7.
4. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood. 1995;85:1504-8.
5. Middeldorp S, Henkens CM, Koopman MM, van Pampus EC, Hamulyák K, van der Meer J, et al. The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis. Ann Intern Med. 1998;128:13-20.
6. Sanson BJ, Friederich PW, Simioni P, Zanardi S, Huisman MV, Girolami A. et al. The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women. Thromb Haemost. 1996;75:387-8.
7. Preston FE, Rosendaal FR, Walker ID, Briët E, Berntorp E, Conard J, et al. Increased fetal loss in women with heritable thrombophilia. Lancet. 1996; 348:913-6.
8. Rai R, Regan L, Hadley E, Dave M, Cohen H. Second-trimester pregnancy loss is associated with activated C resistance. Br J Haematol. 1996;92:489-90.
9. Brenner B, Mandel H, Lanir N, Younis J, Rothbart H, Ohel G, et al. Activated protein C resistance can be associated with recurrent fetal loss. Br J Haematol. 1997;97:551-4.
10. Grandone E, Margaglione M, Colaizzo D, d'Addedda M, Cappucci G, Vecchione G, et al. Factor V Leiden is associated with repeated and recurrent unexplained fetal losses. Thromb Haemost. 1997;77:822-4.
11. Ridker PM, Miletich JP, Buring JE, Ariyo AA, Price DT, Manson JE, et al. Factor V Leiden mutation as a risk factor for recurrent pregnancy loss. Ann Intern Med. 1998;128(12 Pt 1):1000-3.
12. Balasch J, Reverter JC, Fábregues F, Tàssies D, Rafel M, Creus M, et al. First-trimester repeated abortion is not associated with activated protein C resistance. Hum Reprod. 1997;12:1094-7.
13. Dizon-Townson DS, Kinney S, Branch DW, Ward K. The factor V Leiden mutation is not a common cause of recurrent miscarriage. J Reprod Immunol. 1997;34:217-23.
14. Stirrat GM. Recurrent miscarriage I: Definition and epidemiology. Lancet. 1990;336:673-5.
15. Diggle PJ, Liang KY, Zeger SL. Analysis of Longitudinal Data. Oxford: Clarendon Pr; 1994.
16. Rai RS, Regan L, Chitolie A, Donald JG, Cohen H. Placental thrombosis and second trimester miscarriage in association with activated protein C resistance. Br J Obstet Gynaecol. 1996;103:842-4.
17. Dizon-Townson DS, Meline L, Nelson LM, Varner M, Ward K. Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction. Am J Obstet Gynecol. 1997;177:402-5.