Coagulation factor V

International Journal of Biochemistry and Cell Biology

Volumn 36, Issue 8, 2004, Pages 1393-1399

  Duga, Stefano ^a   Asselta, Rosanna ^a   Tenchini, Maria Luisa ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Coagulation factor V; Factor V deficiency; Procoagulant and anticoagulant activities; Thrombophilia

Indexed keywords

AMINO ACID; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8A; COAGULATING AGENT; ENZYME; ENZYME PRECURSOR; PROCOAGULANT; SERINE PROTEINASE; THROMBIN;

AMINO ACID SUBSTITUTION; BIOLOGY; BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING FACTOR 5 DEFICIENCY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INACTIVATION; GENE MUTATION; GENETIC DISORDER; HUMAN; NONHUMAN; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; THROMBOSIS;

EID: 2442618443     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2003.08.002     Document Type: Short Survey

References (15)

1. Bertina R.M., Koeleman B.P., Koster T., Rosendaal F.R., Dirven R.J., de Ronde H., van der Velden P.A., Reitsma P.H. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 369:1994;64-67
2. Cui J., O'Shea K.S., Purkayastha A., Saunders T.L., Ginsburg D. Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Nature. 384:1996;66-68
3. Dahlback B. Activated protein C resistance and thrombosis: molecular mechanisms of hypercoagulable state due to FVR506Q mutation. Semin. Thromb. Hemost. 25:1999;273-289
4. Kalafatis M., Bernardi F., Simioni P., Lunghi B., Girolami A., Mann K.G. Phenotype and genotype expression in pseudohomozygous factor V Leiden: the need for phenotype analysis. Arterioscler. Thromb. Vasc. Biol. 19:1999;336-342
5. Macedo-Ribeiro S., Bode W., Huber R., Quinn-Allen M.A., Kim S.W., Ortel T.L., Bourenkov G.P., Bartunik H.D., Stubbs M.T., Kane W.H., Fuentes-Prior P. Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Nature. 402:1999;434-439
6. Mann K.G., Kalafatis M. Factor V: a combination of Dr. Jekyll and Mr. Hyde. Blood. 101:2003;20-30
7. Montefusco, M. C., Duga, S. Asselta, R., Malcovati, M., Peyvandi, F., Santagostino, E., Mannucci, P. M., & Tenchini, M. L. (2003). Clinical and molecular characterization of 6 patients affected by severe deficiency of coagulation factor V: broadening of the mutational spectrum of factor V gene and in vitro analysis of the newly identified missense mutations. Blood (prepublished on line 19 June 2003; DOI 10.1182/blood-2003-03-0922).
8. Nicolaes G.A., Dahlback B. Factor V and thrombotic disease: description of a janus-faced protein. Arterioscler. Thromb. Vasc. Biol. 22:2002;530-538
9. Nicolaes G.A., Villoutreix B.O., Dahlback B. Partial glycosylation of Asn2181 in human factor V as a cause of molecular and functional heterogeneity. Modulation of glycosylation efficiency by mutagenesis of the consensus sequence for N-linked glycosylation. Biochemistry. 38:1999;13584-13591
10. Norstrom E., Thorelli E., Dahlback B. Functional characterization of recombinant FV Hong Kong and FV Cambridge. Blood. 100:2002;524-530
11. Pellequer J.L., Gale A.J., Getzoff E.D., Griffin J.H. Three-dimensional model of coagulation factor Va bound to activated protein C. Thromb. Haemost. 84:2000;849-857
12. Steen, M., Miteva, M., Villoutreix, B. O., Yamazaki, T., & Dahlback, B. (2003). Factor V New Brunswick: Ala221Val associated with FV deficiency reproduced in vitro and functionally characterized. Blood, 102, 1316-1322.
13. Stormorken H. The discovery of factor V: A tricky clotting factor. J. Thromb. Haemost. 1:2003;206-213
14. Thorelli E., Kaufman R.J., Dahlback B. Cleavage of factor V at Arg506 by activated protein C and the expression of anticoagulant activity of factor V. Blood. 93:1999;2552-2558
15. Yamazaki T., Nicolaes G.A., Sorensen K.W., Dahlback B. Molecular basis of quantitative factor V deficiency associated with factor V R2 haplotype. Blood. 100:2002;2515-2521