High glucose-induced PKC activation mediates TGF-β1 and fibronectin synthesis by peritoneal mesothelial cells

Kidney International

Volumn 59, Issue 2, 2001, Pages 463-470

  Ha, H ^a   Mi Ra Yu, ^a   Hi Bahl Lee, ^a  

^a Soonchunhyang University   (South Korea)

Author keywords

Dialysate; Extracellular matrix; Progressive peritoneal fibrosis; Protein kinase C; Tissue injury; Transforming growth factor ; Ultrafiltration

Indexed keywords

CALPHOSTIN C; DIACYLGLYCEROL; FIBRONECTIN; GLUCOSE; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN; PROTEIN KINASE C; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROSIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MESOTHELIUM CELL; MINK; NONHUMAN; NORTHERN BLOTTING; PERITONEUM; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

EID: 0035135641     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.059002463.x     Document Type: Article

References (34)

1. Sclerotic thickening of the peritoneal membrane in maintenance peritoneal dialysis patients
2. Structural and ultrastructural peritoneal membrane changes and permeability alterations during continuous ambulatory peritoneal dialysis
3. Peritoneal transport in CAPD patients with permanent loss of ultrafiltration capacity
4. Stability of peritoneal solute and water transfer
5. Experimental approaches to diabetic nephropathy
6. Isolation, culture and characterization of human peritoneal mesothelial cells
7. The biology of the mesothelium during peritoneal dialysis
8. Effects of peritoneal effluents on mesothelial cells in culture: Cell proliferation and extracellular matrix regulation
9. Effects of osmotic solutes on fibronectin mRNA expression in rat peritoneal mesothelial cells
10. Transforming growth factor-β in diabetic nephropathy
11. Involvement of transforming growth factor-β and its receptors in the pathogenesis of diabetic nephropathy
12. Sequential effects of high glucose on mesangial cell TGF-β1 and fibronectin synthesis
13. The role of TGF-β in growth inhibition of peritoneal mesothelial cells in high glucose dialysate
14. Effect of glucose on TGF-β 1 expression in peritoneal mesothelial cells
15. High glucose solution and spent dialysis stimulate the synthesis of transforming growth factor-β1 of human peritoneal mesothelial cells: Effects of cytokine costimulation
16. Amelioration of vascular dysfunction in diabetic rats by an oral PKCβ inhibitor
17. Diabetic vascular dysfunctions: A model of excessive activation of protein kinase C
18. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathway
19. Use and specificity of staurosporine, UCN- 01, and calphostin C as protein kinase inhibitors
20. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding
21. The inhibitory mechanism of aloe single component (alprogen) on the mediator release in the guinea pig lung mast cells activated with specific antigen-antibody reactions
22. A rapid method of total lipid extraction and purification
23. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
24. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
25. Autocrine secretion of transforming growth factor-β in cultured rat mesangial cells
26. Enzyme-linked immunoelectrotransfer blot technique for studying the specificities of antigens and antibodies separated by electrophoresis
27. Structure and function of mammalian facilitative sugar transporters
28. Glucose transporters of the glomerulus and the implications for diabetic nephropathy
29. Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids
30. Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissue
31. Autoinduction of transforming growth factor-β1 is mediated by the AP- 1 complex
32. Expression of the fibronectin gene
33. Transcriptional regulation of fibronectin gene by phorbol myristate acetate in hepatoma cells: A negative role for NF-κB
34. Antioxidant inhibition of protein-kinase C signaled increases in transforming growth factor-β in mesangial cells