Genomic targeting of methylated DNA: Influence of methylation on transcription, replication, chromatin structure, and histone acetylation

Molecular and Cellular Biology

Volumn 20, Issue 24, 2000, Pages 9103-9112

  Schubeler D ^a   Lorincz, M C ^a   Cimbora, D M ^a   Telling, A ^a   Feng, Y Q ^a   Bouhassira, E E ^a   Groudine, M ^a  

^a USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; HISTONE; HISTONE H3; HISTONE H4; RNA POLYMERASE;

ACETYLATION; ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA METHYLATION; DNA REPLICATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MODIFICATION; REPORTER GENE; TRANSCRIPTION REGULATION;

ACETYLATION; ANIMALS; ARTIFICIAL GENE FUSION; BLOTTING, SOUTHERN; CELL LINE; CELL NUCLEUS; CHROMATIN; DNA; DNA METHYLATION; DNA REPLICATION; DNA-DIRECTED RNA POLYMERASES; ENHANCER ELEMENTS (GENETICS); FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE TARGETING; GENES, REPORTER; HISTONES; HUMANS; INTEGRASES; PLASMIDS; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSGENES; VIRAL PROTEINS;

ANIMALIA; EUKARYOTA;

EID: 0034458963     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.24.9103-9112.2000     Document Type: Article

References (53)

1. Methylation-induced repression - Belts, braces, and chromatin
2. Repression of genes by DNA methylation depends on CpG density and promoter strength: Evidence for involvement of a methyl-CpG binding protein
3. Tissue-specific factors additively increase the probability of the all-or-none formation of a hypersensitive site
4. Dynamics of DNA methylation during development
5. Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity
6. Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation
7. Long-distance control of origin choice and replication timing in the human beta-globin locus are independent of the locus control region
8. DNA methylation models histone acetylation
9. Position effects are influenced by the orientation of a transgene with respect to flanking chromatin
10. Site-specific chromosomal integration in mammalian cells: Highly efficient CRE recombinase-mediated cassette exchange
11. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus
12. Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions
13. A functional enhancer suppresses silencing of a transgene and prevents its localization close to centrometric heterochromatin
14. DNA methyltransferase Dnmt1 associates with histone deacetylase activity
15. Replication timing of genes and middle repetitive sequences
16. Transcriptional regulation of hemoglobin switching in chicken embryos
17. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
18. Methylation moves into medicine
19. Identification and characterization of a family of mammalian methyl-CpG binding proteins
20. Position effect and related phenomena
21. Dependence of transcriptional repression on CpG methylation density
22. Evidence that protein binding specifies sites of DNA demethylation
23. CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation
24. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
25. DNA methylation and imprinting: Why bother?
26. Cancer epigenetics comes of age
27. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
28. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo
29. DNA methylation directs a time-dependent repression of transcription initiation
30. DNA methylation affects the formation of active chromatin
31. Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation
32. Common mechanisms for the control of eukaryotic transcriptional elongation
33. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
34. Dynamic analysis of proviral induction and de novo methylation: Implications for a histone deacetylase-independent, methylation density-dependent mechanism of transcriptional repression
35. An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA
36. Fine structure genetic analysis of a beta-globin promoter
37. Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2
38. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
39. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
40. Analysis of chromatin structure by in vivo formaldehyde cross-linking
41. Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells
42. Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
43. CpG methylation, chromatin structure, and gene silencing - A three-way connection
44. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
45. DNA methylation inhibits elongation but not initiation of transcription in Neurospora crassa
46. Nuclear localization and histone acetylation: A pathway for chromatin opening and transcriptional activation of the human beta-globin locus
47. DNA cassette exchange in ES cells mediated by Flp recombinase: An efficient strategy for repeated modification of tagged loci by marker-free constructs
48. Temporal order of DNA replication
49. Histone acetylation and transcriptional regulatory mechanisms
50. Control of methylation spreading in synthetic DNA sequences by the murine DNA methyltransferase
51. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
52. Cytosine methylation and the ecology of intragenomic parasites
53. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation