Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: Characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation

Journal of Biological Chemistry

Volumn 280, Issue 17, 2005, Pages 16594-16600

  Li, Haitao ^a   Cui, Hongmei ^a   Liu, Xiaoping ^a   Zweier, Jay L ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DISEASES; ELECTRONS; MAGNETIC RESONANCE SPECTROSCOPY; NITRATES;

ANAEROBIC CONDITIONS; NITRIC OXIDE; ORGANIC NITRATES; XANTHINE OXIDASE (XO);

ENZYMES;

2,3 DIHYDROXYBENZALDEHYDE; ALDEHYDE DERIVATIVE; ASCORBIC ACID; CYSTEINE; DIPHENYLIODONIUM SALT; GUANYLATE CYCLASE; NITRIC OXIDE; NITRITE; NITROSOTHIOL; ORGANIC NITRATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SOLUBLE GUANYLATE CYCLASE; THIOL; THIOL DERIVATIVE; UNCLASSIFIED DRUG; XANTHINE; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR; 2,3-DIHYDROXYBENZALDEHYDE; ANION; BENZALDEHYDE DERIVATIVE; CATECHOL DERIVATIVE; GLUTATHIONE TRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NITRATE; RIBOFLAVIN DERIVATIVE; S NITROSOTHIOL;

ACIDITY; ANAEROBIC METABOLISM; ARTICLE; BIOTRANSFORMATION; CATALYSIS; CATALYST; CHEMOLUMINESCENCE; ELECTRODE; ELECTRON SPIN RESONANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNOASSAY; PRIORITY JOURNAL; REDUCTION; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; ELECTROCHEMISTRY; HEART MUSCLE ISCHEMIA; KINETICS; METABOLISM; PH; PHYSIOLOGY; PROTEIN BINDING; TIME;

ANIONS; BENZALDEHYDES; BINDING SITES; BIOTRANSFORMATION; CATECHOLS; ELECTROCHEMISTRY; ELECTRODES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVATION; FLAVINS; GLUTATHIONE TRANSFERASE; GUANYLATE CYCLASE; HYDROGEN-ION CONCENTRATION; IMMUNOASSAY; KINETICS; MODELS, CHEMICAL; MYOCARDIAL ISCHEMIA; NAD; NITRATES; NITRIC OXIDE; NITRITES; PROTEIN BINDING; S-NITROSOTHIOLS; TIME FACTORS; XANTHINE; XANTHINE OXIDASE;

EID: 20444451649     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411905200     Document Type: Article

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