Antiangiogenic and proapoptotic activities of allyl isothiocyanate inhibit ascites tumor growth in vivo

Integrative Cancer Therapies

Volumn 8, Issue 1, 2009, Pages 75-87

  Kumar, Akhilesh ^a   D'Souza, Saritha S ^a   Tickoo, Sanjay ^b   Salimath, Bharathi P ^a   Singh, H B ^c  

^a UNIVERSITY OF MYSORE   (India)

^b Mustard Research and Promotion Consortium   (India)

^c DEPARTMENT OF SCIENCE AND TECHNOLOGY   (India)

Author keywords

Allyl isothiocyanate; Antiangiogenesis; Apoptosis; Caspase activated DNases; Ehrlich ascites tumor; Essential oils; Vascular endothelial growth factor

Indexed keywords

ALLYL ISOTHIOCYANATE; CASPASE 3; PROTEIN BAX; PROTEIN BCL 2; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL VIABILITY; CHORIOALLANTOIS; CONTROLLED STUDY; DNA DEGRADATION; DNA FRAGMENTATION; EHRLICH ASCITES TUMOR; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TUMOR CELL;

ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; CARCINOMA, EHRLICH TUMOR; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOTHIOCYANATES; MICE; MUSTARD PLANT; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PLANT OILS; RABBITS; RATS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 61849091494     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735408330716     Document Type: Article

References (48)

1. Fenwick GR, Heaney RK Glucosinolates and their breakdown products in cruciferous crops, foods and feedingstuffs. Food Chem. 1983 ; 11: 249-271.
2. Van-Etten CH, Daxenbichler ME, Williams PH, Kwolek WF Glucosinolates and derived products in cruciferous vegetables: analysis of the edible part from twenty-two varieties of cabbage. J Agric Food Chem. 1976 ; 24: 425-455.
3. Van-Etten CH, Daxenbichler ME, Tookey HL, Kwolek WF, Williams PH, Yoder OC Glucosinolates: potential toxicants in cabbage cultivars. J Am Soc Hort Sci. 1980 ; 105: 710-714.
4. Fenwick GR, Heaney RK, Mullin WJ Glucosinolates and their breakdown products in food and food plants. Crit Rev Food Sci Nutr. 1983 ; 18: 123-201.
5. Fahey JW, Zalcmann AT, Talalay P. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry. 2001 ; 56: 5-51.
6. Ioannou YM, Burka LT, Matthews HB Allyl isothiocyanate: comparative disposition in rats and mice. Toxicol Appl Pharmacol. 1984 ; 75: 173-181.
7. Gorler K., Krumbiegel G., Mennicke WH, Siehl HU The metabolism of benzyl isothiocyanate and its cysteine conjugate in guinea-pigs and rabbits. Xenobiotica. 1982 ; 12: 535-542.
8. Chung FL, Morse MA, Eklind KI, Lewis J. Quantitation of human uptake of the anticarcinogen phenethyl isothiocyanate after a watercress meal. Cancer Epidemiol Biomarkers Prev. 1992 ; 1: 383-388.
9. Zhang Y., Talalay P., Cho CG, Posner GH A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA. 1992 ; 89: 2399-2403.
10. Fahey JW, Zhang Y., Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci U S A. 1997 ; 94: 10367-10372.
11. Munday R., Munday CM Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from brassica vegetables. Nutr Cancer. 2002 ; 44: 52-59.
12. Hwang ES, Lee HJ Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration and matrix metalloproteinase-2/ - 9 activities in SK-Hep1 human hepatoma cells. Exp Biol Med. 2006 ; 231: 421-430.
13. Manesh C., Kuttan G. Effect of naturally occurring allyl and phenyl isothiocyanates in the inhibition of experimental pulmonary metastasis induced by B16F-10 melanoma cells. Fitoterapia. 2003 ; 74: 355-363.
14. Lee HP, Gourley L., Duffy SW, Esteve J., Lee L., Day NE Colorectal cancer and diet in an Asian population: a case control study among Singapore Chinese. Int J Cancer. 1989 ; 43: 1007-1016.
15. Mithen RF, Dekker M., Verkerk R., Rabot S., Johnson IT The nutritional significance, biosynthesis and bioavailability of glucosinolates in human foods. J Sci Food Agric. 2000 ; 80: 967-984.
16. Verhoeven DT, Goldbohm RA, Van Poppel G., Verhagen H., Van Den Brandt PA Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev. 1996 ; 5: 733-748.
17. Verhoeven DT, Verhagen H., Goldbohm RA, Van Den Brandt PA, Van Poppel G. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem Biol Interact. 1997 ; 103: 79-129.
18. Lund EK Non-nutritive bioactive constituents of plants: dietary sources and health benefits of glucosinolates. Int J Vitam Nutr Res. 2003 ; 53: 135-143.
19. Folkman J., Cotran RS Relation of vascular proliferation to tumor growth. Int Rev Exp Pathol. 1976 ; 16: 207-248.
20. Gospodarowicz D., Thakaral KK Production of a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum. Proc Natl Acad Sci U S A. 1978 ; 75: 847-851.
21. Greeenberg GB, Hunt TK The proliferative response in vitro of vascular endothelial and smooth muscle cells exposed to wound fluids and macrophages. J Cell Physiol. 1978 ; 97: 353-360.
22. Gimbrone NA, Leapman SB Jr, Cotran RS, Folkman J. Tumor dormancy in vivo by prevention of neovacularization. J Exp Med. 1972 ; 136: 261-276.
23. O'Reilly MS, Holmgren L., Shing Y., Chen C., Rosenthal RA Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastasis by a Lewis lung carcinoma. Cell. 1994 ; 79: 315-328.
24. Maeno T., Tanaka T., Sando Y., Suga T., Maeno Y. Stimulation of vascular endothelial growth factor gene transcription by all trans retionic acid through Sp1 and Sp3 sites in human branchialveolar carcinoma cells. Am J Respir Cell Mol Biol. 2002 ; 26: 246-253.
25. Hengartner MO The biochemistry of apoptosis. Nature. 2000 ; 407: 770-776.
26. Wyllie AH Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 1980 ; 284: 555-570.
27. Rouzaud G., Young SA, Duncan AJ Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers. Cancer Epidemiol Biomarkers Prev. 2004 ; 13: 125-131.
28. Giridharan P., Somasundaram ST, Perumal K., Vishwakarma NP, Velmurugan R. Novel substituted methylenedioxylignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis. Br J Cancer. 2002 ; 87: 98-105.
29. Siemeister G., Schnurr B., Mohrs K., Schachtele C., Marme D., Martiny-Baron G. Expression of biologically active isoforms of the tumor angiogenesis factor VEGF in Escherichia coli. Biophys Biochem Res Commun. 1996 ; 222: 249-255.
30. Belakavadi M., Salimath BP Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase. Mol Cell Biochem. 2005 ; 273: 57-67.
31. Gururaj AE, Belakavadi M., Salimath BP Antiangiogenic effects of butyric acid involve inhibition of VEGF/KDR gene expression and endothelial cell proliferation. Mol Cell Biochem. 2003 ; 243: 107-112.
32. Polverini P., Bouck N., Raztinejad F. Assay and purification of naturally occurring inhibitor of angiogenesis. Methods Enzymol. 1991 ; 198: 440-450.
33. Seo K., Choi J., Park M., Rhe C. Angiogenesis effects of nerve growth factors (NGF) on rat corneas. J Vet Sci. 2001 ; 2: 125-130.
34. Srinivas G., Anto RJ, Srinivas P., Vidyalakshmi S., Priya Senan V., Karunagaran D. Emodin induces apoptosis of human cervical cancer cells through poly (ADP- Ribose) polymerase cleavage and activation of caspase-9. Eur J Pharmacol. 2003 ; 473: 117-125.
35. Fan TP, Yeh JC, Leung KW, Yeu PYK, Wong RNS. Angiogenesis: from plants to blood vessels. Trends Pharmacol Sci. 2006 ; 27: 297-309.
36. Wu WY, Xu O., Shi LC, Zhang WB Inhibitory effects of Curcuma aromatica oil on proliferation of hepatoma in mice. World J Gastroenterol. 2000 ; 6: 216-219.
37. Deepak AV, Salimath BP Antiangiogenic and proapoptotic activity of a novel glycoprotein from U. indica is mediated by NF-kB and caspase activated DNase in ascites tumor model. Biochimie. 2006 ; 88: 297-307.
38. Thippeswamy G., Salimath BP Induction of caspase-3 activated DNase mediated apoptosis by hexane fraction of Tinospora cordifolia in EAT cells. Environ Toxicol Pharmacol. 2007 ; 23: 212-220.
39. Sheela ML, Ramakrishna MK, Salimath BP Angiogenic and proliferative effects of the cytokine VEGF in Ehrlich ascites tumor cells is inhibited by G. glabra. Int Immunopharmacol. 2006 ; 6: 494-498.
40. Widlak P. The DFF-40/CAD endonuclease and its role in apoptosis. Acta Biochim Pol. 2000 ; 47: 1037-1044.
41. Eamshaw WC, Martins LM, Kaufmann SH Mammalian caspase: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem. 1999 ; 68: 383-424.
42. Thornberry N., Lazebnik Y. Caspases: enemies within. Science. 1998 ; 281: 1312-1316.
43. Esposti MD The roles of Bid. Apoptosis. 2002 ; 7: 433-440.
44. Korsmeyer SJ, Wei MC, Saito M., Wieler S., Oh J., Schlesinger PH Proapoptotic cascade activates Bid, which oligomerized BAK or Bax into pores that result in the release of cytochrome C. Cell Death Differ. 2000 ; 7: 1166-1173.
45. Luo X., Budihardjo I., Zou H., Slaughter C., Wang X. Bid, a Bcl-2 interacting protein, mediates cytochrome C release from mitochondria in response to activation of cell death receptors. Cell. 1998 ; 94: 481-490.
46. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998 ; 281: 1322-1326.
47. Cosulich SC, Worrall V., Hedge PJ, Green S., Clarke PR Regulation of apoptosis by BH3 domains in a cell free system. Curr Biol. 1997 ; 7: 913-920.
48. Jean JC, Oakes SM, Joyce-Brady M. The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters. Genomics. 1999 ; 57: 261-269.