-
1
-
-
0028931102
-
CpG motifs in bacterial-DNA trigger direct B-cell activation
-
Krieg A.M., Yi A.K., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., Koretzky G.A., and Klinman D.M. CpG motifs in bacterial-DNA trigger direct B-cell activation. Nature 374 6522 (1995) 546-549
-
(1995)
Nature
, vol.374
, Issue.6522
, pp. 546-549
-
-
Krieg, A.M.1
Yi, A.K.2
Matson, S.3
Waldschmidt, T.J.4
Bishop, G.A.5
Teasdale, R.6
Koretzky, G.A.7
Klinman, D.M.8
-
2
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., and Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 408 6813 (2000) 740-745
-
(2000)
Nature
, vol.408
, Issue.6813
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
Matsumoto, M.7
Hoshino, K.8
Wagner, H.9
Takeda, K.10
Akira, S.11
-
3
-
-
0034886143
-
Toll-like receptors: critical proteins linking innate and acquired immunity
-
Akira S., Takeda K., and Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nature Immunology 2 8 (2001) 675-680
-
(2001)
Nature Immunology
, vol.2
, Issue.8
, pp. 675-680
-
-
Akira, S.1
Takeda, K.2
Kaisho, T.3
-
4
-
-
0004582004
-
CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
-
Millan C.L.B., Weeratna R., Krieg A.M., Siegrist C.A., and Davis H.L. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proceedings of the National Academy of Sciences of the United States of America 95 26 (1998) 15553-15558
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.26
, pp. 15553-15558
-
-
Millan, C.L.B.1
Weeratna, R.2
Krieg, A.M.3
Siegrist, C.A.4
Davis, H.L.5
-
5
-
-
0030764558
-
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
-
Roman M., MartinOrozco E., Goodman S., Nguyen M.D., Sato Y., Ronaghy A., Kornbluth R.S., Richman D.D., Carson D.A., and Raz E. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nature Medicine 3 8 (1997) 849-854
-
(1997)
Nature Medicine
, vol.3
, Issue.8
, pp. 849-854
-
-
Roman, M.1
MartinOrozco, E.2
Goodman, S.3
Nguyen, M.D.4
Sato, Y.5
Ronaghy, A.6
Kornbluth, R.S.7
Richman, D.D.8
Carson, D.A.9
Raz, E.10
-
6
-
-
0030240062
-
Macrophages ingest and are activated by bacterial DNA
-
Stacey K.J., Sweet M.J., and Hume D.A. Macrophages ingest and are activated by bacterial DNA. Journal of Immunology 157 5 (1996) 2116-2122
-
(1996)
Journal of Immunology
, vol.157
, Issue.5
, pp. 2116-2122
-
-
Stacey, K.J.1
Sweet, M.J.2
Hume, D.A.3
-
7
-
-
0032433054
-
Type I interferon-mediated stimulation of T cells by CgG DNA
-
Sun S.Q., Zhang X.H., Tough D.F., and Sprent J. Type I interferon-mediated stimulation of T cells by CgG DNA. Journal of Experimental Medicine 188 12 (1998) 2335-2342
-
(1998)
Journal of Experimental Medicine
, vol.188
, Issue.12
, pp. 2335-2342
-
-
Sun, S.Q.1
Zhang, X.H.2
Tough, D.F.3
Sprent, J.4
-
8
-
-
61749084605
-
Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12
-
Cowdery J.S., Krieg A.M., Hooker N.A., Mildenstein K.L., and Chace J.H. Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12. Journal of Allergy and Clinical Immunology 99 1 (1997) 1970-1970
-
(1997)
Journal of Allergy and Clinical Immunology
, vol.99
, Issue.1
, pp. 1970-1970
-
-
Cowdery, J.S.1
Krieg, A.M.2
Hooker, N.A.3
Mildenstein, K.L.4
Chace, J.H.5
-
9
-
-
0030028722
-
Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha
-
Halpern M.D., Kurlander R.J., and Pisetsky D.S. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. Cellular Immunology 167 1 (1996) 72-78
-
(1996)
Cellular Immunology
, vol.167
, Issue.1
, pp. 72-78
-
-
Halpern, M.D.1
Kurlander, R.J.2
Pisetsky, D.S.3
-
10
-
-
0029670726
-
IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides
-
Yi A.K., Chace J.H., Cowdery J.S., and Krieg A.M. IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. Journal of Immunology 156 2 (1996) 558-564
-
(1996)
Journal of Immunology
, vol.156
, Issue.2
, pp. 558-564
-
-
Yi, A.K.1
Chace, J.H.2
Cowdery, J.S.3
Krieg, A.M.4
-
11
-
-
0033529891
-
CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
-
Hartmann G., Weiner G.J., and Krieg A.M. CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells. Proceedings of the National Academy of Sciences of the United States of America 96 16 (1999) 9305-9310
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.16
, pp. 9305-9310
-
-
Hartmann, G.1
Weiner, G.J.2
Krieg, A.M.3
-
12
-
-
0038717560
-
CpG motifs: the active ingredient in bacterial extracts?
-
Krieg A.M. CpG motifs: the active ingredient in bacterial extracts?. Nature Medicine 9 7 (2003) 831-835
-
(2003)
Nature Medicine
, vol.9
, Issue.7
, pp. 831-835
-
-
Krieg, A.M.1
-
13
-
-
9144238063
-
Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities
-
Vollmer J., Weeratna R., Payette P., Jurk M., Schetter C., Laucht M., Wader T., Tluk S., Liu M., Davis H.L., and Krieg A.M. Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. European Journal of Immunology 34 1 (2004) 251-262
-
(2004)
European Journal of Immunology
, vol.34
, Issue.1
, pp. 251-262
-
-
Vollmer, J.1
Weeratna, R.2
Payette, P.3
Jurk, M.4
Schetter, C.5
Laucht, M.6
Wader, T.7
Tluk, S.8
Liu, M.9
Davis, H.L.10
Krieg, A.M.11
-
14
-
-
34250839522
-
Potent antigen-specific immune responses stimulated by codelivery of CpG ODN and antigens in degradable microparticles
-
Zhang X.Q., Dahle C.E., Baman N.K., Rich N., Weiner G.J., and Salem A.K. Potent antigen-specific immune responses stimulated by codelivery of CpG ODN and antigens in degradable microparticles. Journal of Immunotherapy 30 5 (2007) 469-478
-
(2007)
Journal of Immunotherapy
, vol.30
, Issue.5
, pp. 469-478
-
-
Zhang, X.Q.1
Dahle, C.E.2
Baman, N.K.3
Rich, N.4
Weiner, G.J.5
Salem, A.K.6
-
15
-
-
35848953467
-
A comparative study of the antigen-specific immune response induced by co-delivery of CpG ODN and antigen using fusion molecules or biodegradable microparticles
-
Zhang X.Q., Dahle C.E., Weiner G.J., and Salem A.K. A comparative study of the antigen-specific immune response induced by co-delivery of CpG ODN and antigen using fusion molecules or biodegradable microparticles. Journal of Pharmaceutical Sciences 96 (2007) 3283-3292
-
(2007)
Journal of Pharmaceutical Sciences
, vol.96
, pp. 3283-3292
-
-
Zhang, X.Q.1
Dahle, C.E.2
Weiner, G.J.3
Salem, A.K.4
-
16
-
-
33744903928
-
Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes
-
Zaks K., Jordan M., Guth A., Sellins K., Kedl R., Izzo A., Bosio C., and Dow S. Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes. Journal of Immunology 176 12 (2006) 7335-7345
-
(2006)
Journal of Immunology
, vol.176
, Issue.12
, pp. 7335-7345
-
-
Zaks, K.1
Jordan, M.2
Guth, A.3
Sellins, K.4
Kedl, R.5
Izzo, A.6
Bosio, C.7
Dow, S.8
-
17
-
-
24144439049
-
Multi-component nanorods for vaccination applications
-
Salem A.K., Hung C.F., Kim T.W., Wu T.C., Searson P.C., and Leong K.W. Multi-component nanorods for vaccination applications. Nanotechnology 16 4 (2005) 484-487
-
(2005)
Nanotechnology
, vol.16
, Issue.4
, pp. 484-487
-
-
Salem, A.K.1
Hung, C.F.2
Kim, T.W.3
Wu, T.C.4
Searson, P.C.5
Leong, K.W.6
-
18
-
-
42049103678
-
Pulsatile release of biomolecules from polydimethylsiloxane (PDMS) chips with hydrolytically degradable seals
-
Intra J., Glasgow J.M., Mai H.Q., and Salem A.K. Pulsatile release of biomolecules from polydimethylsiloxane (PDMS) chips with hydrolytically degradable seals. Journal of Controlled Release 127 (2008) 280-287
-
(2008)
Journal of Controlled Release
, vol.127
, pp. 280-287
-
-
Intra, J.1
Glasgow, J.M.2
Mai, H.Q.3
Salem, A.K.4
-
20
-
-
0034681126
-
Cationic microparticles: a potent delivery system for DNA vaccines
-
Singh M., Briones M., Ott G., and O'Hagan D. Cationic microparticles: a potent delivery system for DNA vaccines. Proceedings of the National Academy of Sciences of the United States of America 97 2 (2000) 811-816
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.2
, pp. 811-816
-
-
Singh, M.1
Briones, M.2
Ott, G.3
O'Hagan, D.4
-
21
-
-
12844272901
-
CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine
-
Xie H., Gursel I., Ivins B.E., Singh M., O'Hagan D.T., Ulmer J.B., and Klinman D.M. CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine. Infection and Immunity 73 2 (2005) 828-833
-
(2005)
Infection and Immunity
, vol.73
, Issue.2
, pp. 828-833
-
-
Xie, H.1
Gursel, I.2
Ivins, B.E.3
Singh, M.4
O'Hagan, D.T.5
Ulmer, J.B.6
Klinman, D.M.7
-
22
-
-
34248586071
-
Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN
-
de Jong S., Chikh G., Sekirov L., Raney S., Semple S., Klimuk S., Yuan N., Hope M., Cullis P., and Tam Y. Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN. Cancer Immunology Immunotherapy 56 8 (2007) 1251-1264
-
(2007)
Cancer Immunology Immunotherapy
, vol.56
, Issue.8
, pp. 1251-1264
-
-
de Jong, S.1
Chikh, G.2
Sekirov, L.3
Raney, S.4
Semple, S.5
Klimuk, S.6
Yuan, N.7
Hope, M.8
Cullis, P.9
Tam, Y.10
-
23
-
-
43049176766
-
Co-administration of polyphosphazenes with CpG oligodeoxynucleotides strongly enhances immune responses in mice immunized with Hepatitis B virus surface antigen
-
Mutwiri G., Benjamin P., Soita H., and Babiuk L.A. Co-administration of polyphosphazenes with CpG oligodeoxynucleotides strongly enhances immune responses in mice immunized with Hepatitis B virus surface antigen. Vaccine 26 22 (2008) 2680-2688
-
(2008)
Vaccine
, vol.26
, Issue.22
, pp. 2680-2688
-
-
Mutwiri, G.1
Benjamin, P.2
Soita, H.3
Babiuk, L.A.4
-
24
-
-
15444378922
-
Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines
-
Heit A., Schmitz F., O'Keeffe M., Staib C., Busch D.H., Wagner H., and Huster K.M. Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines. Journal of Immunology 174 7 (2005) 4373-4380
-
(2005)
Journal of Immunology
, vol.174
, Issue.7
, pp. 4373-4380
-
-
Heit, A.1
Schmitz, F.2
O'Keeffe, M.3
Staib, C.4
Busch, D.H.5
Wagner, H.6
Huster, K.M.7
-
25
-
-
0029984358
-
CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
-
Klinman D.M., Yi A.K., Beaucage S.L., Conover J., and Krieg A.M. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proceedings of the National Academy of Sciences of the United States of America 93 7 (1996) 2879-2883
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.7
, pp. 2879-2883
-
-
Klinman, D.M.1
Yi, A.K.2
Beaucage, S.L.3
Conover, J.4
Krieg, A.M.5
-
26
-
-
33644856095
-
Oral administration of CpG-ODNs suppresses antigen-induced asthma in mice
-
Kitagaki K., Businga T.R., and Kline J.N. Oral administration of CpG-ODNs suppresses antigen-induced asthma in mice. Clinical and Experimental Immunology 143 2 (2006) 249-259
-
(2006)
Clinical and Experimental Immunology
, vol.143
, Issue.2
, pp. 249-259
-
-
Kitagaki, K.1
Businga, T.R.2
Kline, J.N.3
-
27
-
-
0032521274
-
Cutting edge: modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
-
Kline J.N., Waldschmidt T.J., Businga T.R., Lemish J.E., Weinstock J.V., Thorne P.S., and Krieg A.M. Cutting edge: modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. Journal of Immunology 160 6 (1998) 2555-2559
-
(1998)
Journal of Immunology
, vol.160
, Issue.6
, pp. 2555-2559
-
-
Kline, J.N.1
Waldschmidt, T.J.2
Businga, T.R.3
Lemish, J.E.4
Weinstock, J.V.5
Thorne, P.S.6
Krieg, A.M.7
-
28
-
-
0030955249
-
Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
-
Weiner G.J., Liu H.M., Wooldridge J.E., Dahle C.E., and Krieg A.M. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proceedings of the National Academy of Sciences of the United States of America 94 20 (1997) 10833-10837
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.20
, pp. 10833-10837
-
-
Weiner, G.J.1
Liu, H.M.2
Wooldridge, J.E.3
Dahle, C.E.4
Krieg, A.M.5
-
29
-
-
33746978211
-
Decreased cytotoxic T cell activity generated by co-administration of PSA vaccine and CpG ODN is associated with increased tumor protection in a mouse model of prostate cancer
-
Lubaroff D.M., Karan D., Andrews M.P., Acosta A., Abouassaly C., Sharma M., and Krieg A.M. Decreased cytotoxic T cell activity generated by co-administration of PSA vaccine and CpG ODN is associated with increased tumor protection in a mouse model of prostate cancer. Vaccine 24 35-36 (2006) 6155-6162
-
(2006)
Vaccine
, vol.24
, Issue.35-36
, pp. 6155-6162
-
-
Lubaroff, D.M.1
Karan, D.2
Andrews, M.P.3
Acosta, A.4
Abouassaly, C.5
Sharma, M.6
Krieg, A.M.7
-
30
-
-
0037439696
-
CpG oligonucleotides enhance the tumor antigen-specific immune response of a granulocyte macrophage colony-stimulating factor-based vaccine strategy in neuroblastoma
-
Sandler A.D., Chihara H., Kobayashi G., Zhu X.Y., Miller M.A., Scott D.L., and Krieg A.M. CpG oligonucleotides enhance the tumor antigen-specific immune response of a granulocyte macrophage colony-stimulating factor-based vaccine strategy in neuroblastoma. Cancer Research 63 2 (2003) 394-399
-
(2003)
Cancer Research
, vol.63
, Issue.2
, pp. 394-399
-
-
Sandler, A.D.1
Chihara, H.2
Kobayashi, G.3
Zhu, X.Y.4
Miller, M.A.5
Scott, D.L.6
Krieg, A.M.7
|