Oral administration of CpG-ODNs suppresses antigen-induced asthma in mice

Clinical and Experimental Immunology

Volumn 143, Issue 2, 2006, Pages 249-259

  Kitagaki, K ^a   Businga, T R ^a   Kline, J N ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b Division of Pulmonary   (United States)

Author keywords

Asthma; Oral; Pathogen associated molecular patterns; Tolerance

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G 2C; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; OVALBUMIN; UNCLASSIFIED DRUG; ANTIGEN; CPG OLIGONUCLEOTIDE; CPG-OLIGONUCLEOTIDE; IMMUNOGLOBULIN G; IMMUNOLOGICAL ADJUVANT; OLIGODEOXYRIBONUCLEOTIDE;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; DESENSITIZATION; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; EOSINOPHILIA; EXPERIMENTAL MODEL; FEMALE; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; TH1 CELL; TREATMENT OUTCOME; ANIMAL; ASTHMA; C57BL MOUSE; DISEASE MODEL; IMMUNOLOGY; METHODOLOGY; ORAL DRUG ADMINISTRATION; RESPIRATORY SYSTEM;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANIMALS; ANTIGENS; ASTHMA; DESENSITIZATION, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; EOSINOPHILIA; FEMALE; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; MICE; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; OVALBUMIN; RESPIRATORY SYSTEM;

EID: 33644856095     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.03003.x     Document Type: Article

References (33)

1. Kline JN Waldschmidt TJ Businga TR Lemish JE Weinstock JV Thorne PS Krieg AM Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma J Immunol 1998 160 2555 9
2. Jain VV Businga TR Kitagaki K George CL O'Shaughnessy PT Kline JN Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure Am J Physiol Lung Cell Mol Physiol 2003 285 L1137 46
3. Sur S Wild JS Choudhury BK Sur N Alam R Klinman DM Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides J Immunol 1999 162 6284 93
4. Schwartz DA Quinn TJ Thorne PS Sayeed S Yi AK Krieg AM CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract J Clin Invest 1997 100 68 73
5. Kline JN Kitagaki K Businga TR Jain VV Treatment of established asthma in a murine model using CpG oligodeoxynucleotides Am J Physiol Lung Cell Mol Physiol 2002 283 L170 9
6. Santeliz JV Nest GV Traquina P Larsen E Wills-Karp M Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma J Allergy Clin Immunol 2002 109 455 62
7. Wohlleben G Erb KJ Atopic disorders: a vaccine around the corner? Trends Immunol 2001 22 618 26
8. Weiner HL Friedman A Miller A et al. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens Annu Rev Immunol 1994 12 809 37
9. Haneda K Sano K Tamura G Sato T Habu S Shirato K TGF-beta induced by oral tolerance ameliorates experimental tracheal eosinophilia J Immunol 1997 159 4484 90
10. Russo M Jancar S Pereira de Siqueira AL, Mengel J, Gomes E, Ficker SM, Caetano de Faria AM. Prevention of lung eosinophilic inflammation by oral tolerance Immunol Lett 1998 61 15 23
11. Nakao A Kasai M Kumano K Nakajima H Kurasawa K Iwamoto I High-dose oral tolerance prevents antigen-induced eosinophil recruitment into the mouse airways Int Immunol 1998 10 387 94
12. Russo M Nahori MA Lefort J et al. Suppression of asthma-like responses in different mouse strains by oral tolerance Am J Respir Cell Mol Biol 2001 24 518 26
13. Karachunski PI Ostlie NS Monfardini C Conti-Fine BM Absence of IFN-gamma or IL-12 has different effects on experimental myasthenia gravis in C57BL/6 mice J Immunol 2000 164 5236 44
14. Zuany-Amorim C Sawicka E Manlius C et al. Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells Nat Med 2002 8 625 9
15. Broide D Schwarze J Tighe H et al. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice J Immunol 1998 161 7054 62
16. McCluskie MJ Davis HL Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants Vaccine 2000 19 413 22
17. Kline JN Krieg AM Waldschmidt TJ Ballas ZK Jain V Businga TR CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma J Allergy Clin Immunol 1999 104 1258 64
18. Heeg K Zimmermann S CpG DNA as a Th1 trigger Int Arch Allergy Immunol 2000 121 87 97
19. Liu N Ohnishi N Ni L Akira S Bacon KB CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells Nat Immunol 2003 4 687 93
20. Kay AB TH2-type cytokines in asthma Ann NY Acad Sci 1996 796 1 8
21. Parronchi P De Carli M Manetti R et al. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones J Immunol 1992 149 2977 83
22. Swain SL Weinberg AD English M Huston G IL-4 directs the development of Th2-like helper effectors J Immunol 1990 145 3796 806
23. Kitagaki K Jain VV Businga TR Hussain I Kline JN Immunomodulatory Effects of CpG Oligodeoxynucleotides on Established Th2 Responses Clin Diagn Laboratory Immunol 2002 9 1260 9
24. Gerhold K Bluemchen K Franke A Stock P Hamelmann E Exposure to endotoxin and allergen in early life and its effect on allergen sensitization in mice J Allergy Clin Immunol 2003 112 389 96
25. Shirota H Sano K Kikuchi T Tamura G Shirato K Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator J Immunol 2000 164 5575 82
26. Horner AA Takabayashi K Beck L et al. Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity J Allergy Clin Immunol 2002 110 413 20
27. Leishman AJ Garside P Mowat AM Induction of oral tolerance in the primed immune system: influence of antigen persistence and adjuvant form Cell Immunol 2000 202 71 8
28. Frew AJ Immunotherapy of allergic disease J Allergy Clin Immunol 2003 111 S712 9
29. Nakajima H Iwamoto I Yoshida S Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea Am Rev Respir Dis 1993 148 1102 4
30. Gavett SH O'Hearn DJ Li X Huang SK Finkelman FD Wills-Karp M Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice J Exp Med 1995 182 1527 36
31. Hansen G Berry G DeKruyff RH Umetsu DT Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation J Clin Invest 1999 103 175 83
32. Randolph DA Carruthers CJ Szabo SJ Murphy KM Chaplin DD Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma J Immunol 1999 162 2375 83
33. Giovane AL Bardare M Passalacqua G Ruffoni S Scordamaglia A Ghezzi E Canonica GW A three-year double-blind placebo-controlled study with specific oral immunotherapy to Dermatophagoides: evidence of safety and efficacy in paediatric patients Clin Exp Allergy 1994 24 53 9