Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes

Development

Volumn 127, Issue 18, 2000, Pages 3961-3970

  Mercader, N ^a   Leonardo, E ^a   Piedra, M E ^a   Martinez A , C ^a   Ros, M A ^a   Torres, M ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Apical ectodermal ridge; Chick; Fibroblast growth factor 8; Hox; Limb; Meis1; Meis2; Proximodistal patterning; Raldh2; Retinoic acid

Indexed keywords

FIBROBLAST GROWTH FACTOR; RETINOIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CELL PROLIFERATION; CONTROLLED STUDY; ECTODERM; GENE CONTROL; GENE EXPRESSION; LIMB DEVELOPMENT; MESODERM; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VERTEBRATE;

ANIMAL; BODY PATTERNING; CHICK EMBRYO; ECTODERM; EXTREMITIES; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; LIMB BUD; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TRETINOIN;

EID: 0033786946     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development
2. Control of the nuclear localization of extradenticle by competing nuclear import and export signals
3. Differential distribution of retinoic acid synthesis in the chicken embryo as determined by immunolocalization of the retinoic acid synthetic enzyme, RALDH-2
4. The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH
5. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin
6. Expression of Meis2, a Knotted-related murine homeobox gene, indicates a role in the differentiation of the forebrain and the somitic mesoderm
7. Fibroblast growth factors induce additional limb development from the flank of chick embryos
8. Limbs: A model for pattern formation within the vertebrate body plan
9. Retinoic acid coordinately proximalizes regenerate pattern and blastema differential affinity in axolotl limbs
10. Roles for FGF8 in the induction, initiation, and maintenance of chick limb development
11. Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene
12. Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis
13. FGF-2: Apical ectodermal ridge growth signal for chick limb development
14. Regulation of HoxA expression in developing and regenerating axolotl limbs
15. Antagonism between extradenticle function and Hedgehog signalling in the developing limb
16. Genetic evidence for the subdivision of the arthropod limb into coxopodite and telopodite
17. Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud
18. Retinoic acid signaling is required during early chick limb development
19. Sorting out of cells from different parts and stages of the chick limb bud
20. Signalling by FGF8 from the isthmus patterns anterior hindbrain and establishes the anterior limit of Hox gene expression
21. Expression of the homeobox Hox-4 genes and the specification of position in chick wing development
22. Molecular models for vertebrate limb development
23. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL
24. Retinoic acid modifies positional memory in the anteroposterior axis of regenerating axolotl limbs
25. The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events
26. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
27. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals
28. Targeted gene mixexpression in chick limb buds using avian replication-competent retroviruses
29. Vitamin A and pattern formation in the regenerating limb
30. The homeotic transformation of tails into limbs in Rana temporaria by retinoids
31. Retinoid receptors in vertebrate limb development
32. Developmental analysis of the retinoic acid-inducible RAR-beta 2 promoter in transgenic animals
33. Conserved regulation of proximodistal limb axis development by Meis1/Hth
34. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
35. Limbs generated at site of tail amputation in marbled balloon frog after vitamin A treatment
36. Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations
37. Meisl, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice
38. Identification of a new family of Pbx-related homeobox genes
39. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
40. Morphological and molecular characterization of retinoic acid-induced limb duplications in mice
41. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb
42. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
43. Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic acid during differentiation of P19 embryonal carcinoma cells
44. Activation of a single retinoic acid receptor isoform mediates proximodistal respecification
45. Extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
46. Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein
47. Methods for manipulating the chick limb bud to study gene expression, tissue interactions and patterning
48. Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis
49. Limb and lower-body duplications induced by retinoic acid in mice
50. The proximodistal sequence of origin of the parts of the chick wing and the role of the ectoderm
51. The homeobox gene NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos
52. Limbs are moving: Where are they going?
53. Analysis of Hox-4.5 and Hox-3.6 expression during newt limb regeneration: Differential regulation of paralogous Hox genes suggest different roles for members of different Hox clusters
54. Retinoic acid is required for the initiation of outgrowth in the chick limb bud
55. Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene
56. The effect of local application of retinoic acid to the anterior margin of the developing chick limb bud
57. Positional information in chick limb morphogenesis
58. Complementary domains of retinoic acid production and degradation in the early chick embryo
59. Retinoic acid changes the proximodistal developmental competence and affinity of distal cells in the developing chick limb bud
60. Local application to retinoic acid to the limb bond mimics the action of the polarizing region
61. Retinoic acid application to chick wing buds leads to a dose-dependent reorganization of the apical ectodermal ridge that is mediated by the mesenchyme
62. Vertebrate limb development
63. A quantitative analysis of the effect of all-trans-retinoic acid on the pattern of chick wing development
64. Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb
65. Detection of messenger RNA by in situ hybridization to tissue sections and whole mount