Time course gene expression in the one-carbon metabolism network using HepG2 cell line grown in folate-deficient medium

Journal of Nutritional Biochemistry

Volumn 20, Issue 4, 2009, Pages 312-320

  Chango, Abalo ^a,b   Nour, Afif Abdel ^a   Bousserouel, Souad ^a   Eveillard, Damien ^c   Anton, Pauline M ^a   Guéant, Jean Louis ^b  

^a INSTITUT POLYTECHNIQUE LASALLE BEAUVAIS   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE NANTES   (France)

Author keywords

Folate; Gene expression; Nutrigenomics; One carbon metabolism

Indexed keywords

FOLIC ACID;

AHCY GENE; ARTICLE; CARBON METABOLISM; CELL STRAIN HEPG2; CONTROLLED STUDY; CTH GENE; GENE; GENE EXPRESSION REGULATION; GNMT GENE; HRFC1 GENE; HUMAN; HUMAN CELL; MAT1A GENE; METHYLATION; MTRR GENE; NUCLEOTIDE SEQUENCE; NUTRIGENOMICS; TRANSCRIPTION REGULATION; VITAMIN METABOLISM;

CARRIER PROTEINS; CELL LINE, TUMOR; FERREDOXIN-NADP REDUCTASE; FOLIC ACID; FOLIC ACID DEFICIENCY; GENE EXPRESSION; HUMANS; MEMBRANE TRANSPORT PROTEINS; RECEPTORS, CELL SURFACE; TIME FACTORS;

EID: 61749104292     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2008.04.004     Document Type: Article

References (38)

1. Abdel Nour A.M., Ringot D., Gueant J.L., and Chango A. Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency. Carcinogenesis 28 11 (2007) 2291-2297
2. Butterworth Jr. C.E., Hatch K.D., Soong S.J., Cole P., Tamura T., Sauberlich H.E., et al. Oral folic acid supplementation for cervical dysplasia: a clinical intervention trial. Am J Obstet Gynecol 166 (1992) 803-809
3. Kang S., Kim J.W., Kang G.H., Park N.H., Song Y.S., Kang S.B., et al. Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer. Gynecol Oncol 96 (2005) 173-180
4. Ergul E., Sazci A., Utkan Z., and Canturk N.Z. Polymorphisms in the MTHFR gene are associated with breast cancer. Tumour Biol 24 (2003) 286-290
5. Larsson S.C., Giovannucci E., and Wolk A. Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst 99 (2007) 64-76
6. Terry P., Jain M., Miller A.B., Howe G.R., and Rohan T.E. Dietary intake of folic acid and colorectal cancer risk in a cohort of women. Int J Cancer 97 (2002) 864-867
7. Choi S.W., and Mason J.B. Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 132 (2002) 2413S-2418S
8. Duthie S.J., Narayanan S., Sharp L., Little J., Basten G., and Powers H. Folate, DNA stability and colorectal neoplasia. Proc Nutr Soc 63 (2004) 571-578
9. Giovannucci E. Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr 132 (2002) 2350S-2355S
10. Pufulete M., Al-Ghnaniem R., Leather A.J., Appleby P., Gout S., Terry C., et al. Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology 124 (2003) 1240-1248
11. Calvert A.H. Biochemical pharmacology of pemetrexed. Oncology (Huntingt) 18 (2004) 13-17
12. Henderson E.A., Bavetsias V., Theti D.S., Wilson S.C., Clauss R., and Jackman A.L. Targeting the alpha-folate receptor with cyclopenta[g]quinazoline-based inhibitors of thymidylate synthase. Bioorg Med Chem 14 (2006) 5020-5042
13. Sergeeva O.A., Khambatta H.G., Cathers B.E., and Sergeeva M.V. Kinetic properties of human thymidylate synthase, an anticancer drug target. Biochem Biophys Res Commun 307 (2003) 297-300
14. Lu Y., and Low P.S. Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv Drug Deliv Rev 54 (2002) 675-693
15. Ni S., Stephenson S.M., and Lee R.J. Folate receptor targeted delivery of liposomal daunorubicin into tumor cells. Anticancer Res 22 (2002) 2131-2135
16. Halsted C.H., Villanueva J.A., and Devlin A.M. Folate deficiency, methionine metabolism, and alcoholic liver disease. Alcohol 27 (2002) 169-172
17. Ji C., and Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124 (2003) 1488-1499
18. Zhu X., Song J., Mar M.H., Edwards L.J., and Zeisel S.H. Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline. Biochem J 370 (2003) 987-993
19. Kharbanda K.K., Rogers II D.D., Mailliard M.E., Siford G.L., Barak A.J., Beckenhauer H.C., et al. Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine. Biochem Pharmacol 70 (2005) 1883-1890
20. Gaull G., Sturman J.A., and Schaffner F. Homocystinuria due to cystathionine synthase deficiency: enzymatic and ultrastructural studies. J Pediatr 84 (1974) 381-390
21. Pfaffl M.W., Horgan G.W., and Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30 (2002) e36
22. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
23. Ballestar E., and Esteller M. The impact of chromatin in human cancer: linking DNA methylation to gene silencing. Carcinogenesis 23 (2002) 1103-1109
24. Baylin S.B. Reversal of gene silencing as a therapeutic target for cancer - roles for DNA methylation and its interdigitation with chromatin. Novartis Found Symp 259 (2004) 226-233 [discussion 227-34, 228-85]
25. Di Croce L., Raker V.A., Corsaro M., Fazi F., Fanelli M., Faretta M., et al. Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science 295 (2002) 1079-1082
26. Nguyen T.T., Cho K., Stratton S.A., and Barton M.C. Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene. Mol Cell Biol 25 (2005) 2147-2157
27. Rice J.C., and Futscher B.W. Transcriptional repression of BRCA1 by aberrant cytosine methylation, histone hypoacetylation and chromatin condensation of the BRCA1 promoter. Nucleic Acids Res 28 (2000) 3233-3239
28. Santos-Reboucas C.B., and Pimentel M.M. Implication of abnormal epigenetic patterns for human diseases. Eur J Hum Genet 15 (2007) 10-17
29. Dammann R., Strunnikova M., Schagdarsurengin U., Rastetter M., Papritz M., Hattenhorst U.E., et al. CpG island methylation and expression of tumour-associated genes in lung carcinoma. Eur J Cancer 41 (2005) 1223-1236
30. Zhao W., Soejima H., Higashimoto K., Nakagawachi T., Urano T., Kudo S., et al. The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. J Biochem (Tokyo) 137 (2005) 431-440
31. Leclerc D., Wilson A., Dumas R., Gafuik C., Song D., Watkins D., et al. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc Natl Acad Sci U S A 95 (1998) 3059-3064
32. Elmore C.L., Wu X., Leclerc D., Watson E.D., Bottiglieri T., Krupenko N.I., et al. Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab 91 (2007) 85-97
33. Yamada K., Gravel R.A., Toraya T., and Matthews R.G. Human methionine synthase reductase is a molecular chaperone for human methionine synthase. Proc Natl Acad Sci U S A 103 (2006) 9476-9481
34. Kim Y.I., Miller J.W., da Costa K.A., Nadeau M., Smith D., Selhub J., et al. Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver. J Nutr 124 (1994) 2197-2203
35. Lees-Murdock D.J., Shovlin T.C., Gardiner T., De Felici M., and Walsh C.P. DNA Methyltransferase expression in the mouse germ line during periods of de novo methylation. Dev Dyn 232 (2005) 992-1002
36. Wang Y.A., Kamarova Y., Shen K.C., Jiang Z., Hahn M.J., Wang Y., et al. DNA Methyltransferase-3a interacts with p53 and represses p53-mediated gene expression. Cancer Biol Ther 4 (2005) 1138-1143
37. Rhee I., Bachman K.E., Park B.H., Jair K.W., Yen R.W., Schuebel K.E., et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416 (2002) 552-556
38. Peyrin-Biroulet L., Barraud H., Darfeuil F., Lefebvre M., Bigard M.A., Gueant J.L., et al. Epigenetic changes and liver carcinogenesis. Gastroenterol Clin Biol 30 (2006) 1354-1359