Targeting the α-folate receptor with cyclopenta[g]quinazoline-based inhibitors of thymidylate synthase

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 14, 2006, Pages 5020-5042

  Henderson, Elisa A ^a   Bavetsias, Vassilios ^a   Theti, Davinder S ^a   Wilson, Stuart C ^a   Clauss, Rainer ^a   Jackman, Ann L ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

folate receptor; FR; DEPC; DIEA; diethyl phosphorocyanidate; diisopropylethylamine; FBP; folate binding protein; Glu; glutamic acid; Pg; propargyl; reduced folate carrier; RFC; TFA; thymidylate synthase; trifluoroacetic acid; TS

Indexed keywords

ALPHA FOLATE RECEPTOR; ANTINEOPLASTIC AGENT; CYCLOPENTA[G]QUINAZOLINE INHIBITOR; FOLATE RECEPTOR; QUINAZOLINE DERIVATIVE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; DRUG INHIBITION; DRUG STRUCTURE; OVARY CARCINOMA; UTERUS CARCINOMA;

CARRIER PROTEINS; CELL LINE; CYCLOPENTANES; ENZYME INHIBITORS; HUMANS; QUINAZOLINES; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE; TRANSFECTION;

EID: 33646783950     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.03.001     Document Type: Article

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