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Volumn 39, Issue 1, 2009, Pages 22-32

Development of an optimized procedure for the preparation of rat intestinal microsomes: Comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains

Author keywords

Cytochromes P450; Intestine; Microsome; Preparation; Rat

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2C11; CYTOCHROME P450 2C6; CYTOCHROME P450 2D2; CYTOCHROME P450 3A; CYTOCHROME P450 3A2; DICLOFENAC; ETHOXYRESORUFIN; MIDAZOLAM; PENTOXYRESORUFIN; PROPRANOLOL; RECOMBINANT ENZYME; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 61649118149     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250802517714     Document Type: Article
Times cited : (33)

References (32)
  • 1
    • 0026324283 scopus 로고
    • Measurement of steroid hydroxylation by high performance liquid chromatography as indicator of P450 identity and function
    • Arlotto MP, Trant JM, Estabook RW. 1991. Measurement of steroid hydroxylation by high performance liquid chromatography as indicator of P450 identity and function. Methods in Enzymology 206:454-462.
    • (1991) Methods in Enzymology , vol.206 , pp. 454-462
    • Arlotto, M.P.1    Trant, J.M.2    Estabook, R.W.3
  • 4
    • 0031840976 scopus 로고    scopus 로고
    • Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine; identified by using inducer treated rat liver microsomes that are characterized with TESTO metabolic patterns
    • Chung WG, Roh HK, Kim HR, Cha YN. 1998. Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine; identified by using inducer treated rat liver microsomes that are characterized with TESTO metabolic patterns. Chemical-Biological Interactions 113:1-14.
    • (1998) Chemical-Biological Interactions , vol.113 , pp. 1-14
    • Chung, W.G.1    Roh, H.K.2    Kim, H.R.3    Cha, Y.N.4
  • 6
    • 0032832513 scopus 로고    scopus 로고
    • Cytochrome P450 isoenzyme specific dealkyltion of alkoxyresorufins in rat brain microsomes
    • Dhawan A, Parmar D, Dayal M, Seth PK. 1999. Cytochrome P450 isoenzyme specific dealkyltion of alkoxyresorufins in rat brain microsomes. Molecular and Cellular Biochemistry 200:169-176.
    • (1999) Molecular and Cellular Biochemistry , vol.200 , pp. 169-176
    • Dhawan, A.1    Parmar, D.2    Dayal, M.3    Seth, P.K.4
  • 7
    • 0036093847 scopus 로고    scopus 로고
    • The mucosa of the small intestine: How clinically relevant as an organ of drug metabolism?
    • Doherty MM, Charmann WN. 2002. The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? Clinical Pharmacokinetics 41:235-253.
    • (2002) Clinical Pharmacokinetics , vol.41 , pp. 235-253
    • Doherty, M.M.1    Charmann, W.N.2
  • 10
    • 0033001766 scopus 로고    scopus 로고
    • Inhibition by retinoids of benzo(-)pyrene metabolism catalysed by 3-methylcholanthrene- induced rat cytochrome P450 1A1
    • Huang DY, Ohnishi T, Jiang H, Furukawa A, Ichikawa Y. 1999. Inhibition by retinoids of benzo(-)pyrene metabolism catalysed by 3-methylcholanthrene- induced rat cytochrome P450 1A1. Metabolism 48:689-692.
    • (1999) Metabolism , vol.48 , pp. 689-692
    • Huang, D.Y.1    Ohnishi, T.2    Jiang, H.3    Furukawa, A.4    Ichikawa, Y.5
  • 11
    • 0032053474 scopus 로고    scopus 로고
    • A specific hydroxysteroid UGT is responsible for the conjugation of aliphatic alcohols in rat: An estimation of the importance of glucuronidation versus oxidation
    • Iwersen S, Schmoldt A. 1997. A specific hydroxysteroid UGT is responsible for the conjugation of aliphatic alcohols in rat: an estimation of the importance of glucuronidation versus oxidation. Alcohol 15:185-192.
    • (1997) Alcohol , vol.15 , pp. 185-192
    • Iwersen, S.1    Schmoldt, A.2
  • 13
    • 0036497073 scopus 로고    scopus 로고
    • Substrate specificity for rat cytochrome P450 (CYP) isoforms: Screening with cDNA-expressed systems of the rat
    • Kobayashi K, Urashima K, Shimada N, Chiba K. 2002. Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochemical Pharmacology 63:889-896.
    • (2002) Biochemical Pharmacology , vol.63 , pp. 889-896
    • Kobayashi, K.1    Urashima, K.2    Shimada, N.3    Chiba, K.4
  • 15
    • 0037275568 scopus 로고    scopus 로고
    • Expression of genes encoding for drug metabolising cytochrome P450 enzymes and P-glycoprotein in the rat small intestine, comparison to the liver
    • Lindell M, Lang M, Lennernäs H. 2003. Expression of genes encoding for drug metabolising cytochrome P450 enzymes and P-glycoprotein in the rat small intestine, comparison to the liver. European Journal of Drug Metabolism and Pharmacokinetics 28:41-48.
    • (2003) European Journal of Drug Metabolism and Pharmacokinetics , vol.28 , pp. 41-48
    • Lindell, M.1    Lang, M.2    Lennernäs, H.3
  • 16
    • 33747833384 scopus 로고    scopus 로고
    • Comparison of intrinsic clearance in liver microsomes and hepatocytes from rat and humans: Evaluation of free fraction and uptake in hepatocytes
    • Lu C, Li P, Gallegos R, Uttamsingh V, Xia CQ, Miw GT, Balani SK, Gan LS. 2006. Comparison of intrinsic clearance in liver microsomes and hepatocytes from rat and humans: evaluation of free fraction and uptake in hepatocytes. Drug Metabolism and Disposition 34:1600-1605.
    • (2006) Drug Metabolism and Disposition , vol.34 , pp. 1600-1605
    • Lu, C.1    Li, P.2    Gallegos, R.3    Uttamsingh, V.4    Xia, C.Q.5    Miw, G.T.6    Balani, S.K.7    Gan, L.S.8
  • 18
    • 44149117977 scopus 로고    scopus 로고
    • Characterization of cytochrome P450 protein expression along the entire length of the intestine of male and female rats
    • Mitschke D, Reichel A, Fricker G, Moenning U. 2008. Characterization of cytochrome P450 protein expression along the entire length of the intestine of male and female rats. Drug Metabolism and Disposition 36:1039-1045.
    • (2008) Drug Metabolism and Disposition , vol.36 , pp. 1039-1045
    • Mitschke, D.1    Reichel, A.2    Fricker, G.3    Moenning, U.4
  • 19
    • 0034812580 scopus 로고    scopus 로고
    • Enzymatic activities in the microsomes prepared from rat small intestinal epithelial cells by differential procedures
    • Mohri K, Uesawa Y. 2001. Enzymatic activities in the microsomes prepared from rat small intestinal epithelial cells by differential procedures. Pharmaceutical Research 18:1232-1236.
    • (2001) Pharmaceutical Research , vol.18 , pp. 1232-1236
    • Mohri, K.1    Uesawa, Y.2
  • 20
    • 0027104748 scopus 로고
    • Metabolite intermediate complexation of microsomal cytochrome P450 2C11 in male rat liver by nortriptyline
    • Murray M. 1992. Metabolite intermediate complexation of microsomal cytochrome P450 2C11 in male rat liver by nortriptyline. Molecular Pharmacology 42:931-938.
    • (1992) Molecular Pharmacology , vol.42 , pp. 931-938
    • Murray, M.1
  • 21
    • 78651165715 scopus 로고
    • The carbon monoxyde-binding pigment of liver microsomes
    • Omura T, Sato R. 1964. The carbon monoxyde-binding pigment of liver microsomes. Journal of Biological Chemistry 239:2370-2378.
    • (1964) Journal of Biological Chemistry , vol.239 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 23
    • 4143125870 scopus 로고    scopus 로고
    • Strain differences in diazepam metabolism at its three metabolic sites in Sprague-Dawley, Brown Norway, Dark Agouti and Wistar strain rats
    • Saito K, Sakai N, Kim HS, Ishizuka M, Kazusaka A, Fujita S. 2004. Strain differences in diazepam metabolism at its three metabolic sites in Sprague-Dawley, Brown Norway, Dark Agouti and Wistar strain rats. Drug Metabolism and Disposition 32:959-965.
    • (2004) Drug Metabolism and Disposition , vol.32 , pp. 959-965
    • Saito, K.1    Sakai, N.2    Kim, H.S.3    Ishizuka, M.4    Kazusaka, A.5    Fujita, S.6
  • 25
    • 0033954275 scopus 로고    scopus 로고
    • Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats
    • Spatzenegger M, Horsmans Y, Verbeeck RK. 2000. Differential activities of CYP1A isozymes in hepatic and intestinal microsomes of control and 3-methylcholanthrene-induced rats. Pharmacology and Toxicology 86:71-77.
    • (2000) Pharmacology and Toxicology , vol.86 , pp. 71-77
    • Spatzenegger, M.1    Horsmans, Y.2    Verbeeck, R.K.3
  • 26
    • 0037232758 scopus 로고    scopus 로고
    • Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransfrases involved in drug metabolism in rat everted sacs and intestinal microsomes
    • Takemoto K, Yamazaki H, Tanaka Y, Nanakajima M, Yokoi T. 2003. Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransfrases involved in drug metabolism in rat everted sacs and intestinal microsomes. Xenobiotica 33:43-55.
    • (2003) Xenobiotica , vol.33 , pp. 43-55
    • Takemoto, K.1    Yamazaki, H.2    Tanaka, Y.3    Nanakajima, M.4    Yokoi, T.5
  • 27
    • 27544446645 scopus 로고    scopus 로고
    • Characterisation of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies
    • Van de Kerkhoff E, De Graaf I, De Jager M, Meijer D, Groothuis G. 2005. Characterisation of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies. Drug Metabolism and Disposition 33:1613-1620.
    • (2005) Drug Metabolism and Disposition , vol.33 , pp. 1613-1620
    • Van de Kerkhoff, E.1    De Graaf, I.2    De Jager, M.3    Meijer, D.4    Groothuis, G.5
  • 29
    • 0028226507 scopus 로고
    • A comparative study of constitutive and induced alkoxyresorufine O-dealkylation and individual cytochrome P450 forms in cynomolgus monkey (Macaca fascicularis), human, mouse, rat and hamster liver microsomes
    • Weaver RJ, Thompson S, Smith G, Dickins M, Elcombe CR, Mayer RT, Burke MD. 1994. A comparative study of constitutive and induced alkoxyresorufine O-dealkylation and individual cytochrome P450 forms in cynomolgus monkey (Macaca fascicularis), human, mouse, rat and hamster liver microsomes. Biochemical Pharmacology 47:763-773.
    • (1994) Biochemical Pharmacology , vol.47 , pp. 763-773
    • Weaver, R.J.1    Thompson, S.2    Smith, G.3    Dickins, M.4    Elcombe, C.R.5    Mayer, R.T.6    Burke, M.D.7
  • 32
    • 9044236908 scopus 로고    scopus 로고
    • Characterization of rat small intestinal cytochrome P450 composition and inducibility
    • Zhang QY, Wikoff J, Dunbar D, Kaminsky L. 1996. Characterization of rat small intestinal cytochrome P450 composition and inducibility. Drug Metabolism and Disposition 24:322-328.
    • (1996) Drug Metabolism and Disposition , vol.24 , pp. 322-328
    • Zhang, Q.Y.1    Wikoff, J.2    Dunbar, D.3    Kaminsky, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.