Characterization of rat small intestinal cytochrome P450 composition and inducibility

Drug Metabolism and Disposition

Volumn 24, Issue 3, 1996, Pages 322-328

  Zhang, Ging Y U ^a   Wikoff, Janet ^a   Dunbar, Deborah ^a   Kaminsky, Laurence ^a  

^a WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; BETA NAPHTHOFLAVONE; CYTOCHROME P450; DEXAMETHASONE; PHENOBARBITAL;

ANIMAL CELL; ARTICLE; DRUG DETOXIFICATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME LOCALIZATION; IMMUNOBLOTTING; INTESTINE EPITHELIUM; LIVER CELL; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SMALL INTESTINE; TISSUE DISTRIBUTION;

ANIMALS; BASE SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; INTESTINE, SMALL; MALE; MICROSOMES, LIVER; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RNA, MESSENGER;

ANIMALIA;

EID: 9044236908     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. D. R. Nelson, T. Kamataki, D. J. Waxman, F. P. Guengerich, R. W. Estabrook, R. Feyereisen, F. J. Gonzalez, M. J. Coon, I. C. Gunsalus, O. Gotoh, K. Okuda, and D. W. Nebert: The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12, 1-51 (1993).
2. L. S. Kaminsky and M. J. Fasco: Small intestinal cytochromes P450. Crit. Rev. Toxicol. 21, 407-422 (1992).
3. M. J. Iatropoulos: Morphology of the gastrointestinal tract. In "Gastrointestinal Toxicology (K. Rozman and O. Dannenen, eds.), p. 246. Elsevier, Amsterdam, 1986.
4. I. de Waziers, P. H. Cugnenc, C. S. Yang, J.-P. Leroux, and P. H. Beaune: Cytochrome P450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. J. Pharmacol. Exp. Ther. 253, 387-394 (1990).
5. P. B. Watkins, S. A. Wrighton, E. G. Schuetz, D. T. Molowa, and P. S. Guzelian: Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J. Clin. Invest. 80, 1029-1036 (1987).
6. H. M. Wortelboer, C. A. de Kruif, A. A. J. van Iersel, J. Noordhoek, B. J. Blaauboer, P. J. van Bladeren, and H. E. Falke: Effects of cooked brussels sprouts on cytochrome P-450 profile and phase II enzymes in liver and small intestinal mucosa of the rat. Food Chem. Toxicol. 30, 17-27 (1992).
7. M. Shimizu, J. M. Lasker, M. Tsutsumi, and C. S. Lieber: Immunohistochemical localization of ethanol-inducible P450IIE1 in the rat alimentary tract. Gastroenterology 99, 1044-1053 (1990).
8. B. J. Roberts, S. E. Shoaf, K.-S. Jeong, and B. J. Song: Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochem. Biophys. Res. Commun. 205, 1064-1071 (1994).
9. M. M. Weiser: Intestinal epithelial cell surface membrane glycoprotein synthesis. J. Biol. Chem. 248, 2536-2541 (1973).
10. M. J. Fasco, J. B. Silkworth, D. A. Dunbar, and L. S. Kaminsky: Rat small intestinal cytochromes P450 probed by warfarin metabolism. Mol. Pharmacol. 43, 226-233 (1993).
11. K. Ivanetich, J. J. Bradshaw, J. A. Marsch, G.G. Harrison, and L. S. Kaminsky: The role of cytochrome P-450 in the toxicity of fluroxene (2,2,2-trifluoroethyl vinyl ether) anaesthesia in vivo. Biochem. Pharmacol 25, 773-778 (1976).
12. T. Omura and R. Sato: The carbon monoxide-binding protein of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem 239, 2370-2378 (1964).
13. U. K. Laemmli: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685 (1970).
14. H. Towbin, T. Staehelin, and J. Gordon: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 76, 4350-4354 (1979).
15. B. D. West, S. Pries, C. H. Shroeder, and K.P. Link: Studies of the 4-hydroxy coumarins. XVII. The resolution and absolute configuration of warfarin. J. Am. Chem. Soc. 83, 2676-2679 (1961).
16. L. S. Kaminsky, M. J. Fasco, and F. P. Guengerich: Production and application of antibodies to rat liver cytochrome P-450. Methods Enzymol 74, 262-272 (1981).
17. F. P. Guengerich, G. A. Dannan, S. T. Wright, M. V. Martin, and L. S. Kaminsky: Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or β-naphthoflavone. Biochemistry 21, 6019-6030 (1982).
18. T.-H. Ueng, Y.-F. Ueng, T.-L. Chen, S. S. Park, M. Iwasaki, and F.P. Guengerich. Induction of cytochrome P450-dependent monooxygenases in hamster tissues by fasting. Toxicol. Appl. Pharmacol. 119, 66-73 (1993).
19. P. T. Liu, C. Ioannides, J. Shavila, A. M. Symons, and D. V. Parke: Effects of ether anaesthesia and fasting on various cytochromes P450 of rat liver and kidney. Biochem. Pharmacol. 45, 871-877 (1993).
20. J. M. Hassing, W. A. al Turk, and S. J. Stohs: Induction of intestinal microsomal enzymes by polycyclic aromatic hydrocarbons. Gen. Pharmacol. 20, 695-700 (1989).
21. C. L. Miranda and R. S. Chhabra: Species differences in stimulation of intestinal and hepatic microsomal mixed-function oxidase enzymes. Biochem. Pharmacol. 29, 1161-1165 (1979).
22. A. V. Hodgson, T. B. White, J. W. White, and H. W. Strobel: Expression analysis of the mixed function oxidase system in rat brain by the polymerase chain reaction. Mol. Cell. Biochem. 120, 171-179 (1993).
23. P. G. Traber, W. Wang, M. McDonnell, and J. J. Gumucio: P450IIB gene expression in rat small intestine: cloning of intestinal P450IIB1 mRNA using the polymerase chain reaction and transcriptional regulation of induction. Mol. Pharmacol. 37, 810-819 (1989).
24. P. G. Zaphiropoulos and T. Wood: Identification of the major cytochrome P450s of subfamily 2C that are expressed in brain of female rats and in olfactory lobes of ethanol treated male rats. Biochem. Biophys. Res. Comm. 193, 1006-1013 (1993).
25. M. Strömstedt, M. Warner, and J.-Å. Gustafsson: Cytochrome P450s of the 4A subfamily in the brain. J. Neurochem. 63, 671-676 (1994).