Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes

Xenobiotica

Volumn 33, Issue 1, 2003, Pages 43-55

  Takemoto, K ^a   Yamazaki, H ^a   Tanaka, Y ^a   Nakajima, M ^a   Yokoi, T ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHOXYCOUMARIN; ALPHA NAPHTHOFLAVONE; BUFURALOL; CYTOCHROME P450 2B1; CYTOCHROME P450 3A2; CYTOCHROME P450 3A4; ETHOXYRESORUFIN; GLUCURONOSYLTRANSFERASE; METYRAPONE; OXYGENASE; QUININE; TESTOSTERONE; TESTOSTERONE 6ALPHA HYDROXYLASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DEALKYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; ENZYME ACTIVITY; FREEZING; IMMUNOREACTIVITY; LIVER MICROSOME; MALE; NONHUMAN; RAT; SMALL INTESTINE; THAWING;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; ETHANOLAMINES; FREEZING; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; IMMUNOBLOTTING; INTESTINES; MALE; MICROSOMES; MICROSOMES, LIVER; MORPHINE; NAPHTHOLS; NITROPHENOLS; OXIDATION-REDUCTION; PHARMACEUTICAL PREPARATIONS; RATS; RATS, WISTAR; TESTOSTERONE; XENOBIOTICS;

ANIMALIA; CINCHONA PUBESCENS;

EID: 0037232758     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/0049825021000022348     Document Type: Article

References (27)

1. Christrup, L. L., 1997, Morphine metabolites. Acta Anaesthesiologica Scandinavia, 41, 116-122.
2. Emoto, C., Yamazaki, H., Yamasaki, S., Shimada, N., Nakajima, M. and Yokoi, T., 2000a, Use of everted sacs of mouse small intestine as enzyme sources for the study of drug oxidation activities in vitro. Xenobiotica, 10, 971-982.
3. Emoto, C., Yamazaki, H., Yamasaki, S., Shimada, N., Nakajima, M. and Yokoi, T., 2000b, Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes. Xenobiotica, 10, 943-953.
4. Fisher, M. B., Campanale, K., Ackermann, B. L., Vandenbranden, M. and Wrighton, S. A., 2000, In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin. Drug Metabolism and Disposition, 28, 560-566.
5. Fisher, M. B., Paine, M. F., Strelevitz, T. J. and Wrighton, S. A., 2001, The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism. Drug Metabolism Reviews, 33, 273-279.
6. Ghabrial, H., Bichara, N., Smallwood, R. A. and Morgan, D. J., 1995, Effect of plasma oestradiol concentration on 4-nitrophenol glucuronidation in the pregnant rat. Journal of Pharmaceutical Science, 1, 27-30.
7. Grams, B., Harms, A., Braun, S., Strassburg, C. P., Manns, M. P. and Obermayer-straub, P., 2000, Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract. Archives of Biochemistry and Biophysics, 377, 255-265.
8. Guengerich, F. P., 1997, Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species. Chemico-Biological Interactions, 106, 161-182.
9. Hanioka, N., Tatarazako, N., Jinno, H., Arizono, K. and Ando, M., 2000, Determination of cyrochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection. Journal of Chromatography B: Biomedical Applications, 744, 399-406.
10. Kashfi, K., McDougall, C. J. and Dannenberg, A. J., 1995, Comparative effects of omeprazole on xenobiotic metabolizing enzymes in the rat and human. Clinical Pharmacology and Therapeutics, 58, 625-630.
11. Koster, A. S., Frankhuijzen-Sierevogel, A. C. and Noordhoek, J., 1985, Distribution of glucuronidation capacity (1-naphthol and morphine) along the rat intestine. Biochemical Pharmacology, 34, 3527-3532.
12. Lear, L., Nation, R. L. and Stupans, I., 1991, Influence of morphine concentration on detergent activation of rat liver morphine-UDP-glucuronosyltransferase. Biochemical Pharmacology, 42 (suppl.), S55-S60.
13. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J., 1951, Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265-275.
14. Mackenzie, P. I. and Hanninen, O., 1980, A sensitive kinetic assay for UDP glucuronosyltransferase using 1-naphthol as substrate. Analytical Biochemistry, 109, 362-368.
15. Mackenzie, P. I., 1995, The UDP-glucuronosyltransferase multigene family. Reviews in Biochemical Toxicology, 11, 29-72.
16. Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Bairoch, A., Belanger, A., Fournel-Gigleux, S., Green, M., Hum, D. W., Iyanagi, T., Lancet, D., Louisot, P., Magdalou, J., Chowdhury, J. R., Ritter, J. K., Schachter, H., Tephly, T. R., Tipton, K. F. and Nebert, D. W., 1997, The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence. Pharmacogenetics, 7, 255-269.
17. Obach, R. S., Zhang, Q. Y., Dunbar, D. and Kaminsky, L. S., 2001, Metabolic characterization of the major human small intestinal cytochrome P450s. Drug Metabolism and Disposition, 29, 347-352.
18. Paine, M. F., Khalighi, M., Fisher, J. M., Shen, D. D., Kunze, K. L., Marsh, C. L., Parkins, J. D. and Thummel, K. E., 1997, Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. Journal of Pharmacology and Experimental Therapeutics, 283, 1552-1562.
19. Prueksaritanont, T., Gorham, L. M., Ma, B., Liu, L., Yu, X., Zhao, J. J., Slaughter, D. E., Arison, B. H. and Vyas, K. P., 1997, In vitro metabolism of simvastatin in humans. Identification of metabolizing enzymes and effect of the drug on hepatic P450s. Drug Metabolism and Disposition, 25, 1191-1199.
20. Rich, K. J., Sesardic, D., Foster, J. R., Davies, D. S. and Boobis, A. R., 1989, Immunohistochemical localization of cytochrome P450b/e in hepatic and extrahepatic tissues of the rat. Biochemical Pharmacology, 38, 3305-3322.
21. Ritter J. K., 2000, Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions. Chemico-Biological Interactions, 129, 171-193.
22. Rosenberg, D. W. and Mankowski, D. C., 1994, Induction of Cyp2e-1 protein in mouse colon. Carcinogenesis, 15, 73-78.
23. Vargas, M. and Franklin, M. R., 1997, Intestinal UDP-glucuronosyltransferase activities in rat and rabbit. Xenobiotica, 27, 413-421.
24. Watkins, P. B., Wrighton, S. A., Schuetz, E. G., Molowa, D. T. and Guzelian, P. S., 1987, Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. Journal of Clinical Investigation, 80, 1029-1036.
25. Yamazaki, H., Tanaka, M. and Shimada, T., 1999, Highly sensitive HPLC assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes. Journal of Chromatography B: Biomedical Applications, 721, 13-19.
26. Zhang, Q.-Y., Wikoff, J., Dunbar, D. and Kaminsky, L., 1996, Characterization of rat small intestinal cytochrome P450 composition and inducibility. Drug Metabolism and Disposition, 24, 322-328.
27. Zhang, Q.-Y., Wikoff, J., Dunbar, D., Fasco, M. and Kaminsky, L., 1997, Regulation of cytochrome P4501A1 expression in rat small intestine. Drug Metabolism and Disposition, 25, 21-26.