메뉴 건너뛰기




Volumn 13, Issue 4, 2008, Pages 333-338

Regulatory T cells: Hypes and limitations

Author keywords

Antigen specific; CD127; Clinical trials; Forkhead box P3; Interleukin 35; Operational tolerance; Rapamycin; Regulatory T cells; Tr1

Indexed keywords

CYCLOSPORIN; RAPAMYCIN;

EID: 61649096596     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e3283061137     Document Type: Review
Times cited : (28)

References (45)
  • 1
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155:1151 -1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3
  • 2
    • 0037364976 scopus 로고    scopus 로고
    • Regulatory T cells in transplantation tolerance
    • Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003; 3:199-210.
    • (2003) Nat Rev Immunol , vol.3 , pp. 199-210
    • Wood, K.J.1    Sakaguchi, S.2
  • 3
    • 33847153417 scopus 로고    scopus 로고
    • Foxp3-dependent programme of regulatory T-cell differentiation
    • Gavin MA, Rasmussen JP, Fontenot JD, et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 2007; 445:771-775.
    • (2007) Nature , vol.445 , pp. 771-775
    • Gavin, M.A.1    Rasmussen, J.P.2    Fontenot, J.D.3
  • 4
    • 33947600584 scopus 로고    scopus 로고
    • Regulatory T cell development in the absence of functional Foxp3
    • Lin W, Haribhai D, Relland LM, et al. Regulatory T cell development in the absence of functional Foxp3. Nat Immunol 2007; 8:359-368.
    • (2007) Nat Immunol , vol.8 , pp. 359-368
    • Lin, W.1    Haribhai, D.2    Relland, L.M.3
  • 5
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
    • Williams LM, Rudensky AY. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 2007; 8:277-284.
    • (2007) Nat Immunol , vol.8 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 6
    • 35948980739 scopus 로고    scopus 로고
    • Deacetylase inhibition promotes the generation and function of regulatory T cells
    • Tao R, de Zoeten EF, Ozkaynak E, et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 2007; 13:1299-1307.
    • (2007) Nat Med , vol.13 , pp. 1299-1307
    • Tao, R.1    de Zoeten, E.F.2    Ozkaynak, E.3
  • 7
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007; 445:766-770.
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 8
    • 33846915397 scopus 로고    scopus 로고
    • Role and mechanisms of CD4+CD25+ regulatory T cells in the induction and maintenance of transplantation tolerance
    • Yong Z, Chang L, Mei YX, Yi L Role and mechanisms of CD4+CD25+ regulatory T cells in the induction and maintenance of transplantation tolerance. Transpl Immunol 2007; 17:120-129.
    • (2007) Transpl Immunol , vol.17 , pp. 120-129
    • Yong, Z.1    Chang, L.2    Mei, Y.X.3    Yi, L.4
  • 9
    • 34250305462 scopus 로고    scopus 로고
    • Chikuma S, Bluestone JA. Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease. EurJ Immunol 2007; 37:1285-1289.
    • Chikuma S, Bluestone JA. Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease. EurJ Immunol 2007; 37:1285-1289.
  • 10
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol 2005; 6:338-344.
    • (2005) Nat Immunol , vol.6 , pp. 338-344
    • von Boehmer, H.1
  • 11
    • 34948883517 scopus 로고    scopus 로고
    • OX40 costimulation turns off Foxp3+ Tregs
    • Vu MD, Xiao X, Gao W, et al. OX40 costimulation turns off Foxp3+ Tregs. Blood 2007; 110:2501 -2510.
    • (2007) Blood , vol.110 , pp. 2501-2510
    • Vu, M.D.1    Xiao, X.2    Gao, W.3
  • 12
    • 33947667952 scopus 로고    scopus 로고
    • GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function
    • Bushell A, Wood K. GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function. Am J Transplant 2007; 7:759-768.
    • (2007) Am J Transplant , vol.7 , pp. 759-768
    • Bushell, A.1    Wood, K.2
  • 13
    • 35248845514 scopus 로고    scopus 로고
    • Role of IFNgamma in allograft tolerance mediated by CD4+CD25+ regulatory T cells by induction of IDO in endothelial cells
    • Thebault P, Condamine T, Heslan M, et al. Role of IFNgamma in allograft tolerance mediated by CD4+CD25+ regulatory T cells by induction of IDO in endothelial cells. Am J Transplant 2007; 7:2472-2482.
    • (2007) Am J Transplant , vol.7 , pp. 2472-2482
    • Thebault, P.1    Condamine, T.2    Heslan, M.3
  • 14
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007; 450:566-569.
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3
  • 15
    • 34548157022 scopus 로고    scopus 로고
    • Understanding FOXP3: Progress towards achieving transplantation tolerance
    • Long E, Wood KJ. Understanding FOXP3: progress towards achieving transplantation tolerance. Transplantation 2007; 84:459-461.
    • (2007) Transplantation , vol.84 , pp. 459-461
    • Long, E.1    Wood, K.J.2
  • 16
    • 34248679904 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in transplantation: Progress, challenges and prospects
    • Kang SM, Tang Q, Bluestone JA. CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects. Am J Transplant 2007; 7: 1457-1463.
    • (2007) Am J Transplant , vol.7 , pp. 1457-1463
    • Kang, S.M.1    Tang, Q.2    Bluestone, J.A.3
  • 17
    • 32644473626 scopus 로고    scopus 로고
    • Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance
    • Battaglia M, Stabilini A, Draghici E, et al. Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance. Diabetes 2006; 55:40-49.
    • (2006) Diabetes , vol.55 , pp. 40-49
    • Battaglia, M.1    Stabilini, A.2    Draghici, E.3
  • 18
    • 34247160468 scopus 로고    scopus 로고
    • Therapeutic use of T regulatory cells
    • Verbsky JW. Therapeutic use of T regulatory cells. Curr Opin Rheumatol 2007; 19:252-258.
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 252-258
    • Verbsky, J.W.1
  • 19
    • 34247359509 scopus 로고    scopus 로고
    • New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses
    • Zhang D, Yang W, Degauque N, et al. New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses. Blood 2007; 109:4071-4079.
    • (2007) Blood , vol.109 , pp. 4071-4079
    • Zhang, D.1    Yang, W.2    Degauque, N.3
  • 20
    • 33846252277 scopus 로고    scopus 로고
    • Multiparameter immune profiling of operational tolerance in liver transplantation
    • Martinez-Llordella M, Puig-Pey I, Orlando G, et al. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant 2007; 7:309-319.
    • (2007) Am J Transplant , vol.7 , pp. 309-319
    • Martinez-Llordella, M.1    Puig-Pey, I.2    Orlando, G.3
  • 21
    • 34547214205 scopus 로고    scopus 로고
    • Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    • Roncarolo MG, Battaglia M. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat Rev Immunol 2007; 7:585-598.
    • (2007) Nat Rev Immunol , vol.7 , pp. 585-598
    • Roncarolo, M.G.1    Battaglia, M.2
  • 22
    • 33846214275 scopus 로고    scopus 로고
    • In vitro-expanded donor alloantigenspecific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance
    • Golshayan D, Jiang S, Tsang J, et al. In vitro-expanded donor alloantigenspecific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance. Blood 2007; 109:827-835.
    • (2007) Blood , vol.109 , pp. 827-835
    • Golshayan, D.1    Jiang, S.2    Tsang, J.3
  • 23
    • 33845933590 scopus 로고    scopus 로고
    • Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: Potential reagents to promote donor-specific transplantation tolerance
    • Jiang S, Tsang J, Game DS, et al. Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: potential reagents to promote donor-specific transplantation tolerance. Transplantation 2006; 82:1738-1743.
    • (2006) Transplantation , vol.82 , pp. 1738-1743
    • Jiang, S.1    Tsang, J.2    Game, D.S.3
  • 24
    • 38049020656 scopus 로고    scopus 로고
    • Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes
    • Joffre O, Santolaria T, Calise D, et al. Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes. Nat Med 2008; 4:88-92.
    • (2008) Nat Med , vol.4 , pp. 88-92
    • Joffre, O.1    Santolaria, T.2    Calise, D.3
  • 25
    • 38549155221 scopus 로고    scopus 로고
    • Chimerismand tolerance in a recipient of a deceased-donor liver transplant
    • Alexander SI, Smith N, Hu M, et al. Chimerismand tolerance in a recipient of a deceased-donor liver transplant. N Engl J Med 2008; 358:369-374.
    • (2008) N Engl J Med , vol.358 , pp. 369-374
    • Alexander, S.I.1    Smith, N.2    Hu, M.3
  • 26
    • 38549088096 scopus 로고    scopus 로고
    • HLA-mismatched renal transplantation without maintenance immunosuppression
    • Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358:353-361.
    • (2008) N Engl J Med , vol.358 , pp. 353-361
    • Kawai, T.1    Cosimi, A.B.2    Spitzer, T.R.3
  • 27
    • 38549134052 scopus 로고    scopus 로고
    • Tolerance and chimerism after renal and hematopoietic-cell transplantation
    • Scandling JD, Busque S, Dejbakhsh-Jones S, et al. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med 2008; 358:362-368.
    • (2008) N Engl J Med , vol.358 , pp. 362-368
    • Scandling, J.D.1    Busque, S.2    Dejbakhsh-Jones, S.3
  • 28
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3and suppressive function of human CD4+Treg cells
    • Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3and suppressive function of human CD4+Treg cells. J Exp Med 2006; 203:1701 -1711.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 29
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki N, Santner-Nanan B, Martinson J, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203:1693-1700.
    • (2006) J Exp Med , vol.203 , pp. 1693-1700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3
  • 30
    • 33845491455 scopus 로고    scopus 로고
    • Only the CD45RA+ subpopulation of CD4+CD25 high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • Hoffmann P, Eder R, Boeld TJ, et al. Only the CD45RA+ subpopulation of CD4+CD25 high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006; 108:4260-4267.
    • (2006) Blood , vol.108 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3
  • 31
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, O'Garra A, Bigler M, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389:737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3
  • 32
    • 0033213948 scopus 로고    scopus 로고
    • Induction of CD4+T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta
    • Zeller JC, Panoskaltsis-Mortari A, Murphy WJ, et al. Induction of CD4+T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta. J Immunol 1999; 163:3684-3691.
    • (1999) J Immunol , vol.163 , pp. 3684-3691
    • Zeller, J.C.1    Panoskaltsis-Mortari, A.2    Murphy, W.J.3
  • 33
    • 34250652403 scopus 로고    scopus 로고
    • Regulation of transplant arteriosclerosis by CD25+CD4+ T cells generated to alloantigen in vivo
    • Warnecke G, Bushell A, Nadig SN, Wood KJ. Regulation of transplant arteriosclerosis by CD25+CD4+ T cells generated to alloantigen in vivo. Transplantation 2007; 83:1459-1465.
    • (2007) Transplantation , vol.83 , pp. 1459-1465
    • Warnecke, G.1    Bushell, A.2    Nadig, S.N.3    Wood, K.J.4
  • 34
    • 34247620262 scopus 로고    scopus 로고
    • Clinical transplantation tolerance: Many rivers to cross
    • Salama AD, Womer KL, Sayegh MH. Clinical transplantation tolerance: many rivers to cross. J Immunol 2007; 178:541 9-5423.
    • (2007) J Immunol , vol.178 , Issue.541 , pp. 9-5423
    • Salama, A.D.1    Womer, K.L.2    Sayegh, M.H.3
  • 35
    • 34147174973 scopus 로고    scopus 로고
    • Intrahepatic detection of FOXP3 gene expression after liver transplantation using minimally invasive aspiration biopsy
    • Demirkiran A, Baan CC, Kok A, et al. Intrahepatic detection of FOXP3 gene expression after liver transplantation using minimally invasive aspiration biopsy. Transplantation 2007; 83:819-823.
    • (2007) Transplantation , vol.83 , pp. 819-823
    • Demirkiran, A.1    Baan, C.C.2    Kok, A.3
  • 36
    • 36249005633 scopus 로고    scopus 로고
    • Achieving donor-specific hyporesponsiveness is associated with FOXP3+ regulatory T cell recruitment in human renal allograft infiltrates
    • Bestard O, Cruzado JM, Mestre M, et al. Achieving donor-specific hyporesponsiveness is associated with FOXP3+ regulatory T cell recruitment in human renal allograft infiltrates. J Immunol 2007; 179:4901 -4909.
    • (2007) J Immunol , vol.179 , pp. 4901-4909
    • Bestard, O.1    Cruzado, J.M.2    Mestre, M.3
  • 37
    • 0344553377 scopus 로고    scopus 로고
    • Heterologous immunity: An overlooked barrier to tolerance
    • Adams AB, Pearson TC, Larsen CP. Heterologous immunity: an overlooked barrier to tolerance. Immunol Rev 2003; 196:147-160.
    • (2003) Immunol Rev , vol.196 , pp. 147-160
    • Adams, A.B.1    Pearson, T.C.2    Larsen, C.P.3
  • 38
    • 38049146019 scopus 로고    scopus 로고
    • Allograft rejection mediated by memory T cells is resistant to regulation
    • Yang J, Brook MO, Carvalho-Gaspar M, et al. Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci USA 2007; 104:19954-19959.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19954-19959
    • Yang, J.1    Brook, M.O.2    Carvalho-Gaspar, M.3
  • 39
    • 38049177784 scopus 로고    scopus 로고
    • Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
    • Zeiser R, Leveson-Gower DB, Zambricki EA, et al. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 2008; 111:453-462.
    • (2008) Blood , vol.111 , pp. 453-462
    • Zeiser, R.1    Leveson-Gower, D.B.2    Zambricki, E.A.3
  • 40
    • 41149113441 scopus 로고    scopus 로고
    • The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
    • Haxhinasto S, Mathis D, Benoist C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med 2008; 205:565-574.
    • (2008) J Exp Med , vol.205 , pp. 565-574
    • Haxhinasto, S.1    Mathis, D.2    Benoist, C.3
  • 41
    • 33845379986 scopus 로고    scopus 로고
    • Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
    • Battaglia M, Stabilini A, MigliavaccaB, et al. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol 2006; 177:8338-8347.
    • (2006) J Immunol , vol.177 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    MigliavaccaB3
  • 42
    • 34249805413 scopus 로고    scopus 로고
    • Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance
    • Turnquist HR, Raimondi G, Zahorchak AF, et al. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol 2007; 178:7018-7031.
    • (2007) J Immunol , vol.178 , pp. 7018-7031
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3
  • 43
    • 37349080895 scopus 로고    scopus 로고
    • Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury
    • Ruggenenti P, Perico N, Gotti E, et al. Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury. Transplantation 2007; 84:956-964.
    • (2007) Transplantation , vol.84 , pp. 956-964
    • Ruggenenti, P.1    Perico, N.2    Gotti, E.3
  • 44
    • 33947249410 scopus 로고    scopus 로고
    • Regulatory T cells and T cell depletion: Role of immunosuppressive drugs
    • Noris M, Casiraghi F, Todeschini M, et al. Regulatory T cells and T cell depletion: role of immunosuppressive drugs. J Am Soc Nephrol 2007; 18:1007-1018.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1007-1018
    • Noris, M.1    Casiraghi, F.2    Todeschini, M.3
  • 45
    • 34548682791 scopus 로고    scopus 로고
    • Reduced numbers of blood natural regulatory T cells in stable liver transplant recipients with high levels of calcineurin inhibitors
    • San Segundo D, Fabrega E, Lopez-Hoyos M, Pons F. Reduced numbers of blood natural regulatory T cells in stable liver transplant recipients with high levels of calcineurin inhibitors. Transplant Proc 2007; 39:2290-2292.
    • (2007) Transplant Proc , vol.39 , pp. 2290-2292
    • San Segundo, D.1    Fabrega, E.2    Lopez-Hoyos, M.3    Pons, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.