Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease

European Journal of Immunology

Volumn 37, Issue 5, 2007, Pages 1285-1289

  Chikuma, Shunsuke ^a,b   Bluestone, Jeffrey A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Autoimmunity; Costimulation; Tolerance

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RECONSTITUTION; KNOCKOUT MOUSE; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; WILD TYPE;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; BONE MARROW TRANSPLANTATION; FORKHEAD TRANSCRIPTION FACTORS; LYMPHOPROLIFERATIVE DISORDERS; MICE; MICE, KNOCKOUT; T-LYMPHOCYTES, REGULATORY;

EID: 34250305462     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737159     Document Type: Article

References (22)

1. Min, B., McHugh, R., Sempowski, G. D., Mackall, C., Foucras, G. and Paul, W. E., Neonates support lymphopenia-induced proliferation. Immunity 2003. 18: 131-140.
2. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004. 22: 531-562.
3. + regulatory T cells. Nat. Immunol. 2003. 4: 330-336.
4. Waterhouse, P., Penninger, J. M., Timms, E., Wakeham, A., Shahinian, A., Lee, K. P., Thompson, C. B. et al., Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995. 270: 985-988.
5. Tivol, E. A., Borriello, F., Schweitzer, A. N., Lynch, W. P., Bluestone, J. A. and Sharpe, A. H., Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory srole of CTLA-4. Immunity 1995. 3: 541-547.
6. Tivol, E. A. and Gorski, J., Re-establishing peripheral tolerance in the absence of CTLA-4: Complementation by wild-type T cells points to an indirect role for CTLA-4. J. Immunol. 2002. 169: 1852-1858.
7. Chikuma, S. and Bluestone, J. A., CTLA-4 and tolerance: The biochemical point of view. Immunol. Res. 2003. 28: 241-253.
8. Karandikar, N. J., Vanderlugt, C. L., Walunas, T. L., Miller, S. D. and Bluestone, J. A., CTLA-4: A negative regulator of autoimmune disease. J. Exp. Med. 1996. 184: 783-788.
9. Luhder, F., Hoglund, P., Allison, J. P., Benoist, C. and Mathis, D., Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 1998. 187: 427-432.
10. Eagar, T. N., Karandikar, N. J., Bluestone, J. A. and Miller, S. D., The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. Eur. J. Immunol. 2002. 32: 972-981.
11. Leach, D. R., Krummel, M. F. and Allison, J. P., Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996. 271: 1734-1736.
12. Quezada, S. A., Peggs, K. S., Curran, M. A. and Allison, J. P., CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J. Clin. Invest. 2006. 116: 1935-1945.
13. Bachmann, M. F., Kohler, G., Ecabert, B., Mak, T. W. and Kopf, M., Cutting Edge: Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J. Immunol. 1999. 163: 1128-1131.
14. Chang, X., Gao, J. X., Jiang, Q., Wen, J., Seifers, N., Su, L., Godfrey, V. L. et al., The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J. Exp. Med. 2005. 202: 1141-1151.
15. Mandelbrot, D. A., McAdam, A. J. and Sharpe, A. H., B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J. Exp. Med. 1999. 189: 435-440.
16. Williams, L. M. and Rudensky, A. Y., Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat. Immunol. 2007. 8: 277-284.
17. + regulatory T cells abrogates their function in vivo. J. Immunol. 2006. 177: 4376-4383.
18. + regulatory T cell function. Eur. J. Immunol. 2004. 34: 2996-3005.
19. Kataoka, H., Takahashi, S., Takase, K., Yamasaki, S., Yokosuka, T., Koike, T. and Saito, T., CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4. Int. Immunol. 2005. 17: 421-427.
20. Engelhardt, J. J., Sullivan, T. J. and Allison, J. P., CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism. J. Immunol. 2006. 177: 1052-1061.
21. Chen, W., Jin, W. and Wahl, S. M., Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells. J. Exp. Med. 1998. 188: 1849-1857.
22. Egen, J. G. and Allison, J. P., Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 2002. 16: 23-35.