Computational approaches for the study of serotonin and its membrane transporter SERT: Implications for drug design in neurological sciences

Current Medicinal Chemistry

Volumn 15, Issue 30, 2008, Pages 3214-3227

  Pratuangdejkul, J ^a,b   Schneider, B ^c   Launay, J M ^a,b,d   Kellermann, O ^c   Manivet, P ^a,b,d  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c CNRS   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

Author keywords

(homology models); 5 HT conformation; Drug Design; Membrane Transporter SERT; Psychiatric disorders; Serotonin

Indexed keywords

COCAINE; ESCITALOPRAM; FLUOXETINE; IMIPRAMINE; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; COMPUTER MODEL; DRUG DESIGN; DRUG INHIBITION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; HUMAN; LIGAND BINDING; MATHEMATICAL COMPUTING; MOLECULAR DOCKING; MOLECULAR MODEL; NEUROMODULATION; NEUROTRANSMITTER UPTAKE; PHARMACOPHORE; PROTEIN CONFORMATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUANTUM CHEMISTRY; REVIEW; SITE DIRECTED MUTAGENESIS; SOLVATION; THREE DIMENSIONAL IMAGING; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; METABOLISM; NEUROSCIENCE; QUANTUM THEORY;

COMPUTER SIMULATION; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEUROSCIENCES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUANTUM THEORY; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 61549119818     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986708786848523     Document Type: Review

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