Photophysics of a neurotransmitter: Ionization and spectroscopic properties of serotonin

Biophysical Journal

Volumn 71, Issue 4, 1996, Pages 1952-1960

  Chattopadhyay, Amitabha ^a   Rukmini, R ^a   Mukherjee, Sushmita ^a,b  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b The New York Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; SEROTONIN RECEPTOR;

ARTICLE; BINDING SITE; COGNITION; DEPRESSION; MOOD; NEUROTRANSMISSION; PAIN; PARTITION CHROMATOGRAPHY; PH; PKA; RECEPTOR BINDING; SLEEP;

EID: 0029817754     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(96)79393-1     Document Type: Article

References (49)

1. Andrews, L. J., and L. S. Forster. 1974. Fluorescence characteristics of indoles in non-polar solvents: lifetimes, quantum yields and polarization spectra. Photochem. Photobiol. 19:353-360.
2. Beddard, G. S. 1983. The photophysics of tryptophan. In Time-Resolved Fluorescence Spectroscopy in Biochemistry and Biology. R. B. Cundall and R. E. Dale, editors. Plenum Publishing Company, New York. 629-633.
3. Beechem, J. M. 1989. A second generation global analysis program for the recovery of complex inhomogeneous fluorescence decay kinetics. Chem. Phys. Lipids. 50:237-251.
4. Beechem, J. M. 1992. Global analysis of biochemical and biophysical data. Methods. Enzymol. 210:37-54.
5. Beechem, J. M., and L. Brand. 1985. Time-resolved fluorescence of proteins. Annu. Rev. Biochem. 54:43-71.
6. Beechem, J. M., E. Gratton, M. Ameloot, J. R. Knutson, and L. Brand. 1991. The global analysis of fluorescence intensity and anisotropy decay data: second-generation theory and programs. In Topics in Fluorescence Spectroscopy, Vol. 2: Principles. J. R. Lakowicz. editor. Plenum Publishing Company, New York. 241-305.
7. Bevington, P. R. 1969. Data Reduction and Error Analysis for the Physical Sciences. McGraw-Hill Book Company, New York.
8. Cases. O., I. Seif, J. Grimsby, P. Gaspar, K. Chen, S. Pournin, U. Muller, M. Aguet, C. Babinet, J. C. Shih, and E. De Maeyer. 1995. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science. 268:1763-1766.
9. 1A serotonin receptor. Mol. Pharmacol. 43: 516-520.
10. Changeux, J.-P., and F. Revah. 1987. The acetylcholine receptor molecule: allosteric sites and the ion channel. Trends Neuroci. 10:245-250.
11. Changeux, J.-P., J. Giraudat, and M. Dennis. 1987. The nicotinic acetylcholine receptor: molecular architecture of a ligand-regulated ion channel. Trends Pharmacol. Sci. 8:459-465.
12. 6 compounds. Science. 150:1593-1595.
13. Dahms, T. E. S., K. J. Willis, and A. G. Szabo. 1995. Conformational heterogeneity of tryptophan in a protein crystal. J. Am. Chem. SDC. 117:2321-2326.
14. De Lauder, W. B., and Ph. Wahl. 1970. pH dependence of the fluorescence decay of tryptophan. Biochemistry. 9:2750-2754.
15. Dixon, R. A. F., I. S. Sigal, M. R. Candelore, R. B. Register. W. Scattergood, E. Rands, and C. D. Strader. 1987. Structural features required for ligand binding to the β-adrenergic receptor. EMBO J. 6:3269-3275.
16. Donnelly, D., and J. B. C. Findlay. 1994. Seven-helix receptors: structure and modelling. Curr. Opin. Struct. Biol. 4:582-589.
17. Eftink, M. R. 1991. Fluorescence techniques for studying protein structure. In Methods of Biochemical Analysis, Vol. 35. C. H. Suelter, editor. John Wiley & Sons. New York. 127-205.
18. Eftink, M. R., Y. Jia, D. Hu, and C. A. Ghiron. 1995. Fluorescence studies with tryplophan analogues: excited state interactions involving the side chain amino group. J. Phys. Chem. 99:5713-5723.
19. Grinvald, A., and I. Z. Steinberg. 1974. On the analysis of fluorescence decay kinetics by the method of least-squares. Anal Biochem. 59: 583-598.
20. Hen, R. 1992. Of mice and flies: commonalities among 5-HT receptors. Trends Pharmacol. Sci. 13:160-165.
21. Jacobs, B. L., and E. C. Azmitia. 1992. Structure and function of the brain serotonin system. Physiol. Rev. 72:165-229.
22. Jameson, D. M., and G. Weber. 1981. Resolution of the pH-dependent heterogeneous fluorescence decay of tryptophan by phase and modulation measurements. J. Phys. Chem. 85:953-958.
23. Karlin, A., P. N. Kao, and M. DiPaola. 1986. Molecular pharmacology of the nicotinic acetylcholine receptor. Trends Pharmacol. Sci. 7:304-308.
24. Krishnan, K. S., and P. Balaram. 1976. A nuclear magnetic resonance study of the interaction of serotonin with gangliosides. FEBS Lett. 63: 313-315.
25. Knutson, J. R., J. M. Beechem, and L. Brand. 1983. Simultaneous analysis of multiple fluorescence decay curves: A global approach. Chem. Phys. Lett. 102:501-507.
26. Lakowicz, J. R. 1983. Principles of Fluorescence Spectroscopy. Plenum Publishing Company, New York.
27. Lampert, R. A., L. A. Chewter, D. Phillips, D. V. O'Connor, A. J. Roberts, and S. R. Meech. 1983. Standards for nanosecond fluorescence decay time measurements. Anal. Chem. 55:68-73.
28. Lide. D. R. 1992. CRC Handbook of Chemistry and Physics. CRC Press, Bocu Raton, FL. 8-51.
29. Lopez-Ibor, J. J. 1988. The involvement of serotonin in psychiatric disorders and behavior, Br. J. Psychiatry: 153 (Suppl. 3):26-39.
30. Ochoa, E. L. M., A. Chattopadhyay. and M. G. McNamee. 1989. Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effects of modulators. Cell. Mol. Neurobiol. 9:141-178.
31. O'Connor, D. V., and D. Phillips. 1984. Time-Correlated Single Photon Counting. Academic Press, London. 180-189.
32. Orteils, M. O., and G. G. Lunt. 1995. Evolutionary history of the ligandgated ion-channel superfamily of receptors. Trends Neurosci. 18: 121-127.
33. Ostrowski, J., M. A. Kjclsberg, M. G. Caron, and R. J. Lefkowitz. 1992. Mutagenesis of the β 2-adrenergic receptor: how structure elucidates function. Annu. Rev. Phurmacol. Toxical. 32:167-183.
34. Parker, C. A., and W. T. Rees. 1960. Correction of fluorescence spectra and measurement of fluorescence quantum efficiency. Analyst. 85: 587-600.
35. Peroutka, S. J. 1993. 5-Hydroxytryptamine receptors. J. Neurochem. 60: 408-416.
36. Ross, J. B. A., W. R. Laws, K. W. Rousslang, and H. R. Wyssbrod. 1992. Tyrosine fluorescence and phosphorescence from proteins and polypeptides. In Topics in Fluorescence Spectroscopy, Vol. 3: Biochemical Applications. J. R. Lakowicz, editor. Plenum Publishing Company, New York. 1-63.
37. A receptors. Trends Pharmacol. Sci. 16:162-168.
38. Strader, C. D., T. M. Fong, M. P. Graziano, and M. R. Tota. 1995. The family of G-protein-coupled receptors. FASEB J. 9:745-754.
39. Strader, C. D., I. S. Sigall, R. B. Register, M. R. Candelore, E. Rands, and R. A. F. Dixon. 1987. Identification of residues required for ligand binding to the β-adrenergic receptor. Proc. Natl. Acad. Sci. USA. 84: 4384-4388.
40. b absorption bands of tryptophan and several other indoles. Biopolymers. 12:1989-1995.
41. Strosberg, A. D. 1991. Structure/function relationship of proteins belonging to the family of receptors coupled to GTP-binding proteins. Eur. J. Biochem. 196:1-10.
42. 1a receptor and ligands. Protein Eng. 6:691-700.
43. Szabo, A. G., and D. M. Rayner. 1980. Fluorescence decay of tryptophan conformers in aqueous solution. J. Am. Chem. Soc. 102:554-563.
44. 2c serotonin receptors. Nature (London). 374:542-546.
45. 2 receptor: identification of amino acids necessary for ligand binding and receptor activation. Mol. Pharmacol 43:931-940.
46. Wilkinson, L. O., and C. T. Dourish. 1991. Serotonin and animal behavior. In Serotonin Receptor Subtypes: Basic and Clinical Aspects. S. J. Peroutka, editor. Wiley-Liss, New York. 147-210.
47. Windholz, M. 1983. The Merck Index. 10th ed. Merck, Rahway, NJ. 1216.
48. Yeh, S.-R., R. A. Fricke, and D. H. Edwards. 1996. The effect of social experience on serotonergic modulation of the escape circuit of crayfish. Science. 271:366-369.
49. Yu, H.-T., M. A. Vela, F. R. Fronczek. M. L. McLaughlin, and M. D. Barkley. 1995. Microenvironmental effects on the solvent quenching rate in constrained tryptophan derivatives. J. Am. Chem. Soc: 117: 348-357.