Novel metabolites of amodiaquine formed by CYP1A1 and CYP1B1: Structure elucidation using electrochemistry, mass spectrometry, and NMR

Drug Metabolism and Disposition

Volumn 37, Issue 3, 2009, Pages 571-579

  Johansson, Tove ^a,b   Jurva, Ulrik ^a   Grönberg, Gunnar ^a   Weidolf, Lars ^a   Masimirembwa, Collen ^c  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c African Institute of Biomedical Science and Technology   (Zimbabwe)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALDEHYDE DERIVATIVE; AMODIAQUINE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DEETHYLAMODIAQUINE; DRUG METABOLITE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG METABOLISM; DRUG OXIDATION; DRUG STRUCTURE; ELECTROCHEMISTRY; ENZYME ACTIVITY; HUMAN; IN VITRO SELECTION; LIVER MICROSOME METABOLISM; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

AMODIAQUINE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP1A1; ELECTROCHEMISTRY; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

RATTUS;

EID: 61449236416     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.025171     Document Type: Article

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