Plant cytokinin analogues with inhibitory activity on cyclin-dependent kinases exert their antiproliferative effect through induction of apoptosis initiated by the mitochondrial pathway: Determination by a multiparametric flow cytometric analysis

Experimental Hematology

Volumn 30, Issue 10, 2002, Pages 1107-1114

  Vermeulen, Katrien ^a   Strnad, Miroslav ^b   Havlícěk, Libor ^b   Van Onckelen, Harry ^a   Lenjou, Marc ^a   Nijs, Griet ^a   Van Bockstaele, Dirk R ^a   Berneman, Zwi N ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 ETHYL 2 HYDROXYETHYLAMINO) 6 (3 HYDROXYBENZYLAMINO) 9 ISOPROPYLPURINE; 2 (1 ETHYL 2 HYDROXYETHYLAMINO) 6 (4 HYDROXYBENZYLAMINO) 9 ISOPROPYLPURINE; 2 (2 AMINOETHYLAMINO) 6 (BENZYLAMINO) 9 ISOPROPYLPURINE; 2 (3 HYDROXYPROPYLAMINO) 6 (2 HYDROXYBENZYLAMINO) 9 ISOPROPYLPURINE; ANTINEOPLASTIC AGENT; CASPASE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYTOKININ; DNA; P 19; P 28; P 29; P 35; PHOSPHATIDYLSERINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE POTENTIAL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA; LEUKEMIA CELL LINE; MICROSCOPY; MITOCHONDRIAL MEMBRANE; POLYMERIZATION; PRIORITY JOURNAL;

ANNEXIN A5; APOPTOSIS; CASPASE 3; CASPASES; CELL CYCLE; CELL DIVISION; CYCLIN-DEPENDENT KINASES; CYTOKININS; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMANS; INTRACELLULAR MEMBRANES; JURKAT CELLS; KINETICS; MITOCHONDRIA; PLANT EXTRACTS; TUMOR CELLS, CULTURED;

EID: 0036791009     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(02)00894-9     Document Type: Article

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