메뉴 건너뛰기




Volumn 29, Issue 1, 2009, Pages 363-369

Promoter methylation primarily occurs in tumor cells of patients with non-small cell lung cancer

Author keywords

Bronchial epithelial cells; Clonal field expansion; Endobronchial brush; Methylation specific pcr; Non small cell lung cancer; Promoter methylation

Indexed keywords

APC 2 PROTEIN; APC PROTEIN; CELL PROTEIN; CHECKPOINT WITH FORKHEAD AND RING FINGER DOMAIN; CYCLIN DEPENDENT KINASE 2 INHIBITOR; CYCLIN DEPENDENT KINASE 2A INHIBITOR; DEATH ASSOCIATED PROTEIN KINASE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR BETA 2; SECRETED FRIZZLED RELATED PROTEIN 1; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR GATA 5; UNCLASSIFIED DRUG;

EID: 61449209083     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (34)

References (42)
  • 1
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG and Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349: 2042-2054, 2003.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 2
    • 4544250024 scopus 로고    scopus 로고
    • Gene-promoter hypermethylation as a biomarker in lung cancer
    • Belinsky SA: Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer 4: 707-717, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 707-717
    • Belinsky, S.A.1
  • 3
    • 0037068329 scopus 로고    scopus 로고
    • DNA methylation analysis: A powerful new tool for lung cancer diagnosis
    • Tsou JA, Hagen JA, Carpenter CL et al: DNA methylation analysis: a powerful new tool for lung cancer diagnosis. Oncogene 21: 5450-5461, 2002.
    • (2002) Oncogene , vol.21 , pp. 5450-5461
    • Tsou, J.A.1    Hagen, J.A.2    Carpenter, C.L.3
  • 4
    • 33845926895 scopus 로고    scopus 로고
    • A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies
    • Shames DS, Girard L, Gao B et al: A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med 3: e486, 2006.
    • (2006) PLoS Med , vol.3
    • Shames, D.S.1    Girard, L.2    Gao, B.3
  • 5
    • 4143132121 scopus 로고    scopus 로고
    • Promoter hypermethylation of resected bronchial margins: A field defect of changes?
    • Guo M, House MG, Hooker C et al: Promoter hypermethylation of resected bronchial margins: a field defect of changes? Clin Cancer Res 10: 5131-5136, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 5131-5136
    • Guo, M.1    House, M.G.2    Hooker, C.3
  • 6
    • 0035132145 scopus 로고    scopus 로고
    • Aberrant promoter methylation of multiple genes in non-small cell lung cancers
    • Zochbauer-Muller S, Fong KM, Virmani AK et al: Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 61: 249-255, 2001.
    • (2001) Cancer Res , vol.61 , pp. 249-255
    • Zochbauer-Muller, S.1    Fong, K.M.2    Virmani, A.K.3
  • 7
    • 3042729741 scopus 로고    scopus 로고
    • Detection of lymph node micrometastases by gene promoter hypermethylation in samples obtained by endosonography-guided fine-needle aspiration biopsy
    • Pellise M, Castells A, Gines A et al: Detection of lymph node micrometastases by gene promoter hypermethylation in samples obtained by endosonography-guided fine-needle aspiration biopsy. Clin Cancer Res 10: 4444-4449, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 4444-4449
    • Pellise, M.1    Castells, A.2    Gines, A.3
  • 8
    • 0037390127 scopus 로고    scopus 로고
    • Gene promoter hypermethylation in tumors and lymph nodes of stage I lung cancer patients
    • Harden SV, Tokumaru Y, Westra WH et al: Gene promoter hypermethylation in tumors and lymph nodes of stage I lung cancer patients. Clin Cancer Res 9: 1370-1375, 2003.
    • (2003) Clin Cancer Res , vol.9 , pp. 1370-1375
    • Harden, S.V.1    Tokumaru, Y.2    Westra, W.H.3
  • 9
    • 0034666334 scopus 로고    scopus 로고
    • Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers
    • Kersting M, Friedl C, Kraus A et al: Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers. J Clin Oncol 18: 3221-3229, 2000.
    • (2000) J Clin Oncol , vol.18 , pp. 3221-3229
    • Kersting, M.1    Friedl, C.2    Kraus, A.3
  • 10
    • 0032894125 scopus 로고    scopus 로고
    • Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients
    • Esteller M, Sanchez-Cespedes M, Rosell R et al: Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res 59: 67-70, 1999.
    • (1999) Cancer Res , vol.59 , pp. 67-70
    • Esteller, M.1    Sanchez-Cespedes, M.2    Rosell, R.3
  • 11
    • 1842426642 scopus 로고    scopus 로고
    • Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer
    • Topaloglu O, Hoque MO, Tokumaru Y et al: Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer. Clin Cancer Res 10: 2284-2288, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 2284-2288
    • Topaloglu, O.1    Hoque, M.O.2    Tokumaru, Y.3
  • 12
    • 2942737264 scopus 로고    scopus 로고
    • Tumor-specific methylation in bronchial lavage for the early detection of non-small cell lung cancer
    • Kim H, Kwon YM, Kim JS et al: Tumor-specific methylation in bronchial lavage for the early detection of non-small cell lung cancer. J Clin Oncol 22: 2363-2370, 2004.
    • (2004) J Clin Oncol , vol.22 , pp. 2363-2370
    • Kim, H.1    Kwon, Y.M.2    Kim, J.S.3
  • 13
    • 23244436976 scopus 로고    scopus 로고
    • Aberrant promoter methylation of p16(INK4a), RARB2 and SEMA3B in bronchial aspirates from patients with suspected lung cancer
    • Grote HJ, Schmiemann V, Geddert H et al: Aberrant promoter methylation of p16(INK4a), RARB2 and SEMA3B in bronchial aspirates from patients with suspected lung cancer. Int J Cancer 116: 720-725, 2005.
    • (2005) Int J Cancer , vol.116 , pp. 720-725
    • Grote, H.J.1    Schmiemann, V.2    Geddert, H.3
  • 14
    • 27744434546 scopus 로고    scopus 로고
    • Methylation assay for the diagnosis of lung cancer on bronchial aspirates: A cohort study
    • Schmiemann V, Booking A, Kazimirek M et al: Methylation assay for the diagnosis of lung cancer on bronchial aspirates: a cohort study. Clin Cancer Res 11: 7728-7734, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 7728-7734
    • Schmiemann, V.1    Booking, A.2    Kazimirek, M.3
  • 15
    • 0034326238 scopus 로고    scopus 로고
    • Predicting lung cancer by detecting aberrant promoter methylation in sputum
    • Palmisano WA, Divine KK, Saccomanno G et al: Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res 60: 5954-5958, 2000.
    • (2000) Cancer Res , vol.60 , pp. 5954-5958
    • Palmisano, W.A.1    Divine, K.K.2    Saccomanno, G.3
  • 16
    • 25144439378 scopus 로고    scopus 로고
    • Assessing abnormal gene promoter methylation in paraffin-embedded sputum from patients with NSCLC
    • Olaussen KA, Soria JC, Park YW et al: Assessing abnormal gene promoter methylation in paraffin-embedded sputum from patients with NSCLC. Eur J Cancer 41: 2112-2119, 2005.
    • (2005) Eur J Cancer , vol.41 , pp. 2112-2119
    • Olaussen, K.A.1    Soria, J.C.2    Park, Y.W.3
  • 17
    • 0142053910 scopus 로고    scopus 로고
    • Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers
    • Zochbauer-Muller S, Lam S, Toyooka S et al: Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers. Int J Cancer 107: 612-616, 2003.
    • (2003) Int J Cancer , vol.107 , pp. 612-616
    • Zochbauer-Muller, S.1    Lam, S.2    Toyooka, S.3
  • 18
    • 0037081176 scopus 로고    scopus 로고
    • Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers
    • Soria JC, Rodriguez M, Liu DD et al: Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers. Cancer Res 62: 351-355, 2002.
    • (2002) Cancer Res , vol.62 , pp. 351-355
    • Soria, J.C.1    Rodriguez, M.2    Liu, D.D.3
  • 19
    • 33645521023 scopus 로고    scopus 로고
    • Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort
    • Belinsky SA, Liechty KC, Gentry FD et al: Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res 66: 3338-3344, 2006.
    • (2006) Cancer Res , vol.66 , pp. 3338-3344
    • Belinsky, S.A.1    Liechty, K.C.2    Gentry, F.D.3
  • 20
    • 0037089460 scopus 로고    scopus 로고
    • Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers
    • Belinsky SA, Palmisano WA, Gilliland FD et al: Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res 62: 2370-2377, 2002.
    • (2002) Cancer Res , vol.62 , pp. 2370-2377
    • Belinsky, S.A.1    Palmisano, W.A.2    Gilliland, F.D.3
  • 21
    • 0035870282 scopus 로고    scopus 로고
    • p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
    • Kim DH, Nelson HH, Wiencke JK et al: p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Res 61: 3419-3424, 2001.
    • (2001) Cancer Res , vol.61 , pp. 3419-3424
    • Kim, D.H.1    Nelson, H.H.2    Wiencke, J.K.3
  • 22
    • 34548513807 scopus 로고    scopus 로고
    • Promoter hyper-methylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers
    • Yanagawa N, Tamura G, Oizumi H et al: Promoter hyper-methylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers. Lung Cancer 58: 131-138, 2007.
    • (2007) Lung Cancer , vol.58 , pp. 131-138
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3
  • 23
    • 34250795615 scopus 로고    scopus 로고
    • Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers
    • Liu Y, Gao W, Siegfried JM et al: Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers. BMC Cancer 7: 74, 2007.
    • (2007) BMC Cancer , vol.7 , pp. 74
    • Liu, Y.1    Gao, W.2    Siegfried, J.M.3
  • 24
    • 0037446974 scopus 로고    scopus 로고
    • A genetic explanation of Slaughter's concept of field cancerization: Evidence and clinical implications
    • Braakhuis BJ, Tabor MP, Kummer JA et al: A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res 63: 1727-1730, 2003.
    • (2003) Cancer Res , vol.63 , pp. 1727-1730
    • Braakhuis, B.J.1    Tabor, M.P.2    Kummer, J.A.3
  • 25
    • 78651056338 scopus 로고
    • Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin
    • Slaughter DP, Southwick HW and Smejkal W: Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6: 963-968, 1953.
    • (1953) Cancer , vol.6 , pp. 963-968
    • Slaughter, D.P.1    Southwick, H.W.2    Smejkal, W.3
  • 26
    • 0035989409 scopus 로고    scopus 로고
    • Bronchial epithelial cell B7-1 and B7-2 mRNA expression after lung transplantation: A role in allograft rejection?
    • Elssner A, Jaumann F, Wolf WP et al: Bronchial epithelial cell B7-1 and B7-2 mRNA expression after lung transplantation: a role in allograft rejection? Eur Respir J 20: 165-169, 2002.
    • (2002) Eur Respir J , vol.20 , pp. 165-169
    • Elssner, A.1    Jaumann, F.2    Wolf, W.P.3
  • 27
    • 3042719079 scopus 로고    scopus 로고
    • Effects of cigarette smoke on the human airway epithelial cell transcriptome
    • Spira A, Beane J, Shah V et al: Effects of cigarette smoke on the human airway epithelial cell transcriptome. Proc Natl Acad Sci USA 101: 10143-10148, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10143-10148
    • Spira, A.1    Beane, J.2    Shah, V.3
  • 28
    • 0029843950 scopus 로고    scopus 로고
    • Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
    • Herman JG, Graff JR, Myohanen S et al: Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93: 9821-9826, 1996.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9821-9826
    • Herman, J.G.1    Graff, J.R.2    Myohanen, S.3
  • 29
    • 0037427808 scopus 로고    scopus 로고
    • Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer
    • Toyooka S, Maruyama R, Toyooka KO et al: Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer 103: 153-160, 2003.
    • (2003) Int J Cancer , vol.103 , pp. 153-160
    • Toyooka, S.1    Maruyama, R.2    Toyooka, K.O.3
  • 30
    • 33847749502 scopus 로고    scopus 로고
    • Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer
    • Spira A, Beane JE, Shah V et al: Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med 13: 361-366, 2007.
    • (2007) Nat Med , vol.13 , pp. 361-366
    • Spira, A.1    Beane, J.E.2    Shah, V.3
  • 31
    • 0032578509 scopus 로고    scopus 로고
    • Aberrant methylation p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
    • Belinsky SA, Nikula KJ, Palmisano WA et al: Aberrant methylation p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci USA 95: 11891-11896, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11891-11896
    • Belinsky, S.A.1    Nikula, K.J.2    Palmisano, W.A.3
  • 32
    • 25144438960 scopus 로고    scopus 로고
    • Gene promoter methylation in plasma and sputum increases with lung cancer risk
    • Belinsky SA, Klinge DM, Dekker JD et al: Gene promoter methylation in plasma and sputum increases with lung cancer risk. Clin Cancer Res 11: 6505-6511, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 6505-6511
    • Belinsky, S.A.1    Klinge, D.M.2    Dekker, J.D.3
  • 33
    • 31844452687 scopus 로고    scopus 로고
    • Methylation profile in tumor and sputum samples of lung cancer patients detected by spiral computed tomography: A nested case-control study
    • Cirincione R, Lintas C, Conte D et al: Methylation profile in tumor and sputum samples of lung cancer patients detected by spiral computed tomography: A nested case-control study. Int J Cancer 118: 1248-1253, 2006.
    • (2006) Int J Cancer , vol.118 , pp. 1248-1253
    • Cirincione, R.1    Lintas, C.2    Conte, D.3
  • 34
    • 12144291697 scopus 로고    scopus 로고
    • K-ras and p16(INK4A) alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers
    • Destro A, Bianchi P, Alloisio M et al: K-ras and p16(INK4A) alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers. Lung Cancer 44: 23-32, 2004.
    • (2004) Lung Cancer , vol.44 , pp. 23-32
    • Destro, A.1    Bianchi, P.2    Alloisio, M.3
  • 35
    • 2942548985 scopus 로고    scopus 로고
    • Aberrant methylation of the adenomatous polyposis coli promoter 1A in bronchial aspirates from patients with suspected lung cancer
    • Grote HJ, Schmiemann V, Kiel S et al: Aberrant methylation of the adenomatous polyposis coli promoter 1A in bronchial aspirates from patients with suspected lung cancer. Int J Cancer 110: 751-755, 2004.
    • (2004) Int J Cancer , vol.110 , pp. 751-755
    • Grote, H.J.1    Schmiemann, V.2    Kiel, S.3
  • 36
    • 17644414480 scopus 로고    scopus 로고
    • Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer
    • Russo AL, Thiagalingam A, Pan H et al: Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res 11: 2466-2470, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 2466-2470
    • Russo, A.L.1    Thiagalingam, A.2    Pan, H.3
  • 37
    • 33845662751 scopus 로고    scopus 로고
    • Application of a methylation gene panel by quantitative PCR for lung cancers
    • Shivapurkar N, Stastny V, Suzuki M et al: Application of a methylation gene panel by quantitative PCR for lung cancers. Cancer Lett 247: 56-71, 2007.
    • (2007) Cancer Lett , vol.247 , pp. 56-71
    • Shivapurkar, N.1    Stastny, V.2    Suzuki, M.3
  • 38
    • 33846187641 scopus 로고    scopus 로고
    • Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer
    • Gu J, Berman D, Lu C et al: Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer. Clin Cancer Res 12: 7329-7338, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 7329-7338
    • Gu, J.1    Berman, D.2    Lu, C.3
  • 39
    • 27244450828 scopus 로고    scopus 로고
    • Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects
    • Hoque MO, Topaloglu O, Begum S et al: Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects. J Clin Oncol 23: 6569-6575, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 6569-6575
    • Hoque, M.O.1    Topaloglu, O.2    Begum, S.3
  • 40
    • 20044383744 scopus 로고    scopus 로고
    • Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers
    • Divine KK, Pulling LC, Marron-Terada PG et al: Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers. Int J Cancer 114: 400-405, 2005.
    • (2005) Int J Cancer , vol.114 , pp. 400-405
    • Divine, K.K.1    Pulling, L.C.2    Marron-Terada, P.G.3
  • 41
    • 8444253477 scopus 로고    scopus 로고
    • Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung
    • Kim JS, Kim H, Shim YM et al: Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung. Carcinogenesis, 2004.
    • (2004) Carcinogenesis
    • Kim, J.S.1    Kim, H.2    Shim, Y.M.3
  • 42
    • 8444238560 scopus 로고    scopus 로고
    • Clinicopathological significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer
    • Tomizawa Y, lijima H, Nomoto T et al: Clinicopathological significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer. Lung Cancer 46: 305-312, 2004.
    • (2004) Lung Cancer , vol.46 , pp. 305-312
    • Tomizawa, Y.1    lijima, H.2    Nomoto, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.