Nutritional supplements for older adults: Review and recommendations-part i

Journal of Nutrition for the Elderly

Volumn 28, Issue 1, 2009, Pages 5-29

  Buhr, Gwendolen ^a   Bales, Connie W ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antioxidants; Calcium; Multivitamin minerals; Nutritional supplements; Selenium; Vitamin A; Vitamin C; Vitamin D; Vitamin E

Indexed keywords

MINERAL; VITAMIN;

AGED; AGING; ARTICLE; DIET SUPPLEMENTATION; DRUG EFFECT; EVIDENCE BASED MEDICINE; FEMALE; HEALTH CARE POLICY; HUMAN; MALE; NUTRITIONAL REQUIREMENT; NUTRITIONAL STATUS; PHYSIOLOGY; RISK ASSESSMENT; STATISTICS;

AGED; AGING; DIETARY SUPPLEMENTS; EVIDENCE-BASED MEDICINE; FEMALE; HUMANS; MALE; MINERALS; NUTRITION POLICY; NUTRITIONAL REQUIREMENTS; NUTRITIONAL STATUS; RISK ASSESSMENT; VITAMINS;

EID: 61449165119     PISSN: 01639366     EISSN: 15408566     Source Type: Journal    
DOI: 10.1080/01639360802640545     Document Type: Article

References (93)

1. Wakimoto P, Block G. Dietary intake, dietary patterns, and changes with age: An epidemiological perspective. J Gerontol A Biol Sci Med Sci. 2001;56(Sρec No 2):65-80.
2. Feldblum I, German L, Castel H, et al. Characteristics of undernourished older medical patients and the identification of predictors for undernutrition status. Nutr J. 2007;6:37.
3. Pauly L, Stehle P, Volkert D. Nutritional situation of elderly nursing home residents. Z Gerontol Geriatr. 2007;40(1):3-12.
4. Nutritional Supplements in the U.S. 2006. Accessed at www.marketresearch.com9 January 2009-
5. Rock CL. Multivitamin-multimineral supplements: who uses them? Am J Clin Nutr. 2007;85(1):277S-279S.
6. Timbo BB, Ross MP, McCarthy PV, Lin CT. Dietary supplements in a national survey: Prevalence of use and reports of adverse events. / Am Diet Assoc, 200ó;106(12): 1966-74.
7. Ervin RB, Wright JD, Kennedy-Stephenson J. Use of dietary supplements in the United States, 1988-94. Vital Health Stat 11. 1999(244):i-iii, 1-14.
8. Houston DK, Johnson MA, Daniel TD, Poon LW. Health and dietary characteristics of supplement users in an elderly population. Int J Vitam Nutr Res. 1997;67(3): 183-91.
9. Foote JA, Giuliano AR, Harris RB. Older adults need guidance to meet nutritional recommendations. J Am Coll Nutr. 2000;19(5):628-40.
10. Sebastian RS, Cleveland LE, Goldman JD, Moshfegh AJ. Older adults who use vitamin/mineral supplements differ from nonusers in nutrient intake adequacy and dietary attitudes. J Am Diet Assoc. 2007;107(8):1322-32.
11. Lichtenstein AH, Rasmussen H, Yu WW, Epstein SR, Russell RM. Modified MyPyramid for Older Adults. J Nutr. 2008;138(1):5-11.
12. Hasslberger S. Europe Sharply Divided over Vitamin Supplements. Health Supreme. 2008; 2006. Accessed at www.newmediaexplorer.org/sepp/2006/12/ 06/euroρe-divided on 6 December 2008.
13. Patterson RE, Neuhouser ML, Hedderson MM, Schwartz SM, Standish LJ, Bowen DJ. Changes in diet, physical activity, and supplement use among adults diagnosed with cancer. J Am Diet Assoc. 2003; 103(3):323-8.
14. Radimer K, Bindewald B, Hughes J, Ervin B, Swanson C, Picciano MF. Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999-2000. Am J Epidemiol. 2004;160(4):4-339.
15. Prentice RL. Clinical trials and observational studies to assess the chronic disease benefits and risks of multivitamin-multimineral supplements. Am J Clin Nutr. 2007;85(1):308S-313S.
16. Morris CD, Carson S. Routine vitamin supplementation to prevent cardiovascular disease: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2003;139(l):l-56.
17. Christen WG, Gaziano JM, Hennekens CH. Design of Physicians' Health Study II-a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials. Ann Epidemiol. 2000;10(2): 125-34.
18. Fletcher RH, Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications. JAMA. 2002;287(23):3127-9.
19. Jasti S, Siega-Riz AM, Bentley ME. Dietary supplement use in the context of health disparities: cultural, ethnic and demographic determinants of use. / Nutr. 2003;133(6):2010S-2013S.
20. Kilonzo MM, Vale LD, Cook JA, Milne AC, Stephen AI, Avenell A. A cost-utility analysis of multivitamin and multimineral supplements in men and women aged 65 years and over. Clin Nutr. 2007;26(3):364-70.
21. New study finds increased multivitamin use by the elderly could save medicare $1.6 billion. PR Newswire. New York; 2003. Accessed at http://proquest.umi. com/pqdweb?vinst= on 17 November 2008.
22. Ford ES, Ajani UA, Mokdad AH. Brief communication: The prevalence of high intake of vitamin E from the use of supplements among U.S. adults. Ann Intern Med. 2005;143(2):l16-20.
23. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes F, and Nutrition Board, Institute of Medicine. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: National Academy Press; 2000.
24. Ervin RB, Wright JD, Reed-Gillette D. Prevalence of leading types of dietary supplements used in the Third National Health and Nutrition Examination Survey, 1988-94. Advance Data 2004(349): 1-7.
25. Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vita mins for the prevention of cardiovascular disease: meta-analysis of randomised trials. The Lancet. 2003;361(9374):2017-2023.
26. Eidelman RS, Hollar D, Hebert PR, Lamas GA, Hennekens CH. Randomized Trials of Vitamin E in the Treatment and Prevention of Cardiovascular Disease. Arch Intern Med. 2004;164(14):1552-1556.
27. Flores-Mateo G, Navas-Acien A, Pastor-Barriuso R, Guallar E. Selenium and coronary heart disease: a meta-analysis. Am J Clin Nutr. 2006;84(4):762-773.
28. Shekelle P, Morton S, Hardy M. Effect of supplemental antioxidants vitamin C, vitamin E, and coenzyme Q10 for the prevention and treatement of cardiovascular disease. Evidence report/technology assessment. 2003; 28.
29. Leppala JM, Virtamo J, Fogelholm R, et al. Controlled trial of alpha-tocopherol and beta-carotene supplements on stroke incidence and mortality in male smokers. Arteriosclerosis, Thrombosis, and Vascular Biology 2000;20(l):230-5.
30. Sesso HD, Buring JE, Christen WG, et al. Vitamins E and C in the prevention of cardiovascular disease in men: The Physicians' Health Study II randomized controlled trial. JAMA. 2008;300(18):2123-33. Epub 2008 Nov 9.
31. Bleys J, Miller ER, III, Pastor-Barriuso R, Appel LJ, Guallar E. Vitamin-mineral supplementation and the progression of atherosclerosis: A meta-analysis of randomized controlled trials. Am J Clin Nutr. 2006;84(4):880-887.
32. Hercberg S, Galan P, Preziosi P, et al. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med. 2004;164(21):2335-42.
33. Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: The Women's Health Study: a randomized controlled trial. JAMA. 2005;294(l):1-5ó.
34. Cook NR, Albert CM, Gaziano JM, et al. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch Intern Med. 2007; 167(15): 1610-8.
35. Bardia A, Tleyjeh IM, Cerhan JR, et al. Efficacy of antioxidant supplementation in reducing primary cancer incidence and mortality: Systematic review and metaanalysis. Mayo Clin Proc. 2008;83(l):23-24.
36. Clark LC, Dalkin B, Krongrad A, et al. Decreased incidence of prostate cancer with selenium supplementation: Results of a double-blind cancer prevention trial. Br J Urol. 1998;81(5):730-4.
37. Coulter ID, Hardy ML, Morton SC, et al. Antioxidants vitamin C and vitamin E for the prevention and treatment of cancer. / Gen Intern Med. 2006;21(7):735̃44.
38. Gallicchio L, Boyd K, Matanoski G, et al. Carotenoids and the risk of developing lung cancer: a systematic review. Am J Clin Nutr. 2008;88(2):372-83.
39. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. lancet. 2004;364(9441):1219-28.
40. Klein EA, Thompson IM, Lippman SM, et al. SELECT: The selenium and vitamin E cancer prevention trial. Urol Oncol. 2003;21(1):59-65.
41. Evans J. Antioxidant supplements to prevent or slow down the progression of AMD: A systematic review and meta-analysis. Eye 2008;22(6):751-60. Epub 2008 Apr 18.
42. Chong EW, Wong TY, Kreis AJ, Simpson JA, Guymer RH. Dietary antioxidants and primary prevention of age related macular degeneration: Systematic review and meta-analysis. BMJ. 2007;335(7623):755. Epub 2007 Oct 8.
43. Evans JR, Henshaw K. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database Syst Rev. 2008(1):CD000253.
44. Evans JR. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev. 2006(2):CD000254.
45. Age-Related Eye Disease Study Research Group, A randomized, placebocontrolled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001;119Ü0):1417-36.
46. Charkoudian LD, Gower EW, Solomon SD, Schachat AP, Bressler NM, Dressler SB. Vitamin usage patterns in the prevention of advanced age-related macular degeneration. Ophthalmology. 2008;115(6):1032-1038. e4. Epub 2007 Dec 21.
47. Miller ER, 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142(l):37-46.
48. Bjelakovic G, Níkolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007;297(8):842-57.
49. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2008(2):CD007176.
50. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med. 1994;330(15): 1029-35.
51. Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med, 1996;334(18):1150-5.
52. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA, 2002;287(1):47-54.
53. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med. 2003; 348(4): 287-94.
54. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for vitamin C. vitamin E, selenium, and carotenoids. Washington, D.C.: National Academy Press; 2000.
55. U.S. Preventive Services Task Force. Routine Vitamin Supplementation to Prevent Cancer and Cardiovascular Disease: Recommendations and Rationale. Rockville, MD: Agency for Healthcare Research and Quality; June 2003.
56. Holick MF, Chen TC. Vitamin D deficiency: A worldwide problem with health consequences. Am J Clin Nutt. 2008;87(4):1080S-6S.
57. Janssen HC, Samson MM, Verhaar HJ. Vitamin D deficiency, muscle function, and falls in elderly people. AmJ Clin Nutr, 2002;75(4):61l-5.
58. Holick MF. Vitamin D: Importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr, 2004;79(3):3-362.
59. Garland CF, Garland FC, Gorham ED, et al. The role of vitamin D in cancer prevention. AmJ Public Health. 2006;96(2):252-61. Epub 2005 Dec 27.
60. Bischoff-Ferrari HA. Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes. Adv Exp Med Biol. 2008;624:55-71.
61. Hypponen E, Power C. Vitamin D status and glucose homeostasis in the 1958 British birth cohort: The role of obesity. Diabetes Care. 2006;29(10):2244-6.
62. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. AmJ Clin Nutr. 2000;72(3):690-3.
63. Suter PM, Golner BB, Goldin BR, Morrow FD, Russell RM. Reversal of proteinbound vitamin B12 malabsorption with antibiotics in atrophic gastritis. Gastroenterology. 1991;101(4):1039-45.
64. Moore C, Murphy MM, Keast DR, Holick MF. Vitamin D intake in the United States. J Am Diet Assoc. 2004;104(6):980-3.
65. Greenspan SL, Resnick NM, Parker RA. Vitamin D supplementation in older women. / Gerontol A Biol Sci Med Sci. 2005;60(6):754-9.
66. Souberbielle JC, Cormier C, Kindermans C, et al. Vitamin D status and redefining serum parathyroid hormone reference range in the elderly. / Clin Endocrinol Metab. 2001;86(7):3086-90.
67. Kiebzak GM, Moore NL, Margolis S, Hollis B, Kevorkian CG. Vitamin D status of patients admitted to a hospital rehabilitation unit: Relationship to function and progress. Am J Phys Med Rebabil. 2007;86(6):435-45.
68. Malik R. Vitamin D and secondary hyperparathyroidism in the institutionalized elderly: A literature review. J Nutr Elder, 2007;26(3-4): 119-38.
69. Ervin RB, Kennedy-Stephenson J. Mineral intakes of elderly adult supplement and non-supplement users in the third national health and nutrition examination survey. J Nutr. 2002;132(ll):3422-7.
70. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: A meta-analysis of randomized controlled trials. JAMA. 2005;293(18):2257- ó4.
71. Avenell A, Gillespie WJ, Gillespie LD, O'Connell DL. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and postmenopausal osteoporosis. Cochrane Database Syst Rev. 2005(3):CD000227.
72. Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 200ó;354(7):ó69-83.
73. Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P. Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: Evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metαb. 2007;92(4): 1415-23. Epub 2007 Jan 30.
74. Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: A meta-analysis. Lancet. 2007;370(9588):657-66.
75. Bischoff-Ferrari HA, Rees JR, Grau MV, Barry E, Gui J, Baron JA. Effect of calcium supplementation on fracture risk: A double-blind randomized controlled trial. Am J Clin Nutr. 2008;87(6):1945-51.
76. Reid IR, Bolland MJ, Grey A. Effect of calcium supplementation on hip fractures. Osteoporos Int. 2008;19(8): 1119-23. Epub 2008 Feb 20-23.
77. Dawson-Hughes B. A Revised Clinician's Guide to the Prevention and Treatment of Osteoporosis./ Clin EndocrinolMetab. 2008;93(7):2463- 24ó5. Epub 2008 Jun 10.
78. Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: A randomized controlled trial. / Bone Miner Res. 2003;18(2):343-51.
79. Flicker L, Maclnnis RJ, Stein MS, et al. Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. J Am Geriatr Soc. 2005;53(11): 1881-8.
80. Broe KE, Chen TC, Weinberg J, Bischoff-Ferrari HA, Holick MF, Kiel DP. A higher dose of vitamin d reduces the risk of falls in nursing home residents: A randomized, multiple-dose study. J A m Geriatr Soc. 2007; 55(2): 234-9.
81. Prince RL, Austin N, Devine A, Dick IM, Bruce D, Zhu K. Effects of ergocalciferol added to calcium on the risk of falls in elderly high-risk women. Arch Intern Med. 2008; 168(1): 103-8.
82. Law M, Withers H, Morris J, Anderson F. Vitamin D supplementation and the prevention of fractures and falls: Results of a randomised trial in elderly people in residential accommodation. Age Ageing 2006;35(5):482-6. Epub 2006 Apr 26.
83. Dawson-Hughes B, Bischoff-Ferrari HA. Therapy of osteoporosis with calcium and vitamin D. J Bone Miner Res. 2007;22(Suρρl 2):V59-63.
84. Bischoff-Ferrari HA. The 25-hydroxyvitamin D threshold for better health. JSteroid Biochem Mol Biol. 2007;103(3-5):614-9. Epub 2007 Jan 16.
85. Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J Clin Nutr. 2007;85Ü):6-18.
86. 2 in elderly subjects. J Clin Endocrinol Metab. 198ó;63(3):656-60.
87. Ilahi M, Armas LA, Heaney RP. Pharmacokinetics of a single, large dose of cholecalciferol. Am J Clin Nutr. 2008;87(3):688-91.
88. Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. AmJ Clin Nutr. 2006;84(4):694-7.
89. 3 in maintaining circulating concentrations of 25-hydroxyvitamin D. / Clin Endocrinol Metab. 2008;93(3):677-81. Epub 2007 Dec 18.
90. Vieth R. Vitamin D toxicity, policy, and science. JBone Miner Res. 2007;22(Suppl 2):V64-8.
91. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. Bmj. 2008;336(7638):262-6. Epub 2008 Jan 15.
92. Tang BM, Nordin BE. Calcium supplementation does not increase mortality. Med JAust. 2008;188(9):547.
93. Hsia J, Heiss G, Ren H, et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation 2007;115(7):846-54.