The 25-hydroxyvitamin D threshold for better health

Journal of Steroid Biochemistry and Molecular Biology

Volumn 103, Issue 3-5, 2007, Pages 614-619

  Bischoff Ferrari, Heike A ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

25 hydroxyvitamin D; Adherence; Bone density; Cancer; Function; Threshold

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; COLECALCIFEROL; ERGOCALCIFEROL; PLACEBO; VITAMIN D;

ARTICLE; BONE DENSITY; CANCER PREVENTION; CLINICAL TRIAL; COST BENEFIT ANALYSIS; DRUG DOSE COMPARISON; DRUG EFFICACY; FALL RISK; FALLING; FRACTURE; FRACTURE REDUCTION; HUMAN; PATIENT COMPLIANCE; PUBLIC HEALTH; VITAMIN BLOOD LEVEL; VITAMIN INTAKE;

BONE DENSITY; FRACTURES, BONE; HEALTH; HUMANS; LOWER EXTREMITY; NEOPLASMS; RISK FACTORS; VITAMIN D;

EID: 33947152982     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2006.12.016     Document Type: Article

References (64)

1. Lips P., Wiersinga A., van Ginkel F.C., et al. The effect of Vitamin D supplementation on Vitamin D status and parathyroid function in elderly subjects. J. Clin. Endocrinol. Metab. 67 4 (1988) 644-650
2. Malabanan A., Veronikis I.E., and Holick M.F. Redefining Vitamin D insufficiency. Lancet 351 9105 (1998) 805-806
3. Peacock M. Effects of calcium and Vitamin D insufficiency on the skeleton. Osteoporos. Int. 8 Suppl. 2 (1998) S45-S51
4. Chapuy M.C., Preziosi P., Maamer M., et al. Prevalence of Vitamin D insufficiency in an adult normal population. Osteoporos. Int. 7 5 (1997) 439-443
5. Dawson-Hughes B., Harris S.S., and Dallal G.E. Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women. Am. J. Clin. Nutr. 65 1 (1997) 67-71
6. Krall E.A., Sahyoun N., Tannenbaum S., Dallal G.E., and Dawson-Hughes B. Effect of Vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N. Engl. J. Med. 321 26 (1989) 1777-1783
7. Freaney R., McBrinn Y., and McKenna M.J. Secondary hyperparathyroidism in elderly people: combined effect of renal insufficiency and Vitamin D deficiency. Am. J. Clin. Nutr. 58 2 (1993) 187-191
8. Dawson-Hughes B., Stern D.T., Shipp C.C., and Rasmussen H.M. Effect of lowering dietary calcium intake on fractional whole body calcium retention. J. Clin. Endocrinol. Metab. 67 1 (1988) 62-68
9. Kitamura N., Shigeno C., Shiomi K., et al. Episodic fluctuation in serum intact parathyroid hormone concentration in men. J. Clin. Endocrinol. Metab. 70 1 (1990) 252-263
10. Bischoff H., Stahelin H.B., Vogt P., et al. Immobility as a major cause of bone remodeling in residents of a long-stay geriatric ward. Calcif. Tissue Int. 64 6 (1999) 485-489
11. McKenna M.J. Differences in Vitamin D status between countries in young adults and the elderly. Am. J. Med. 93 1 (1992) 69-77
12. Lips P., Graafmans W.C., Ooms M.E., Bezemer P.D., and Bouter L.M. Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial. Ann. Intern. Med. 124 4 (1996) 400-406
13. Bouillon R.A., Auwerx J.H., Lissens W.D., and Pelemans W.K. Vitamin D status in the elderly: seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency. Am. J. Clin. Nutr. 45 4 (1987) 755-763
14. Theiler R., Stahelin H.B., Tyndall A., Binder K., Somorjai G., and Bischoff H.A. Calcidiol, calcitriol and parathyroid hormone serum concentrations in institutionalized and ambulatory elderly in Switzerland. Int. J. Vitam. Nutr. Res. 69 2 (1999) 96-105
15. Bischoff-Ferrari H.A., Dietrich T., Orav E.J., et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged ≥60 y. Am. J. Clin. Nutr. 80 3 (2004) 752-758
16. Dawson-Hughes B., Harris S.S., Krall E.A., and Dallal G.E. Effect of calcium and Vitamin D supplementation on bone density in men and women 65 years of age or older. N. Engl. J. Med. 337 10 (1997) 670-676
17. Lips P., Chapuy M.C., Dawson-Hughes B., Pols H.A., and Holick M.F. An international comparison of serum 25-hydroxyvitamin D measurements. Osteoporos. Int. 9 5 (1999) 394-397
18. Bischoff-Ferrari H.A., Dietrich T., Orav E.J., and Dawson-Hughes B. Positive association between 25-hydroxy vitamin d levels and bone mineral density: a population-based study of younger and older adults. Am. J. Med. 116 9 (2004) 634-639
19. Cummings S.R., Nevitt M.C., Browner W.S., et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N. Engl. J. Med. 332 12 (1995) 767-773
20. Chapuy M.C., Arlot M.E., Duboeuf F., et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N. Engl. J. Med. 327 23 (1992) 1637-1642
21. Ooms M.E., Roos J.C., Bezemer P.D., van der Vijgh W.J., Bouter L.M., and Lips P. Prevention of bone loss by Vitamin D supplementation in elderly women: a randomized double-blind trial. J. Clin. Endocrinol. Metab. 80 4 (1995) 1052-1058
22. Tabensky A., Duan Y., Edmonds J., and Seeman E. The contribution of reduced peak accrual of bone and age-related bone loss to osteoporosis at the spine and hip: insights from the daughters of women with vertebral or hip fractures. J. Bone Miner. Res. 16 6 (2001) 1101-1107
23. Boland R. Role of Vitamin D in skeletal muscle function. Endocrine Rev. 7 (1986) 434-447
24. Glerup H., Mikkelsen K., Poulsen L., et al. Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif. Tissue Int. 66 6 (2000) 419-424
25. Birge S.J., and Haddad J.G. 25-Hydroxycholecalciferol stimulation of muscle metabolism. J. Clin. Invest. 56 5 (1975) 1100-1107
26. Bischoff H.A., Stahelin H.B., Dick W., et al. Effects of Vitamin D and calcium supplementation on falls: a randomized controlled trial. J. Bone Miner. Res. 18 2 (2003) 343-351
27. Sorensen O.H., Lund B., Saltin B., et al. Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium. Clin. Sci. (Colch.) 56 2 (1979) 157-161
28. Visser M., Deeg D.J., and Lips P. Low Vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J. Clin. Endocrinol. Metab. 88 12 (2003) 5766-5772
29. Sharkey J.R., Giuliani C., Haines P.S., Branch L.G., Busby-Whitehead J., and Zohoori N. Summary measure of dietary musculoskeletal nutrient (calcium, Vitamin D, magnesium, and phosphorus) intakes is associated with lower-extremity physical performance in homebound elderly men and women. Am. J. Clin. Nutr. 77 4 (2003) 847-856
30. Guralnik J.M., Ferrucci L., Simonsick E.M., Salive M.E., and Wallace R.B. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N. Engl. J. Med. 332 9 (1995) 556-561
31. Seeman T.E., Charpentier P.A., Berkman L.F., et al. Predicting changes in physical performance in a high-functioning elderly cohort: MacArthur studies of successful aging. J. Gerontol. 49 3 (1994) M97-M108
32. Wicherts I.S., Schoor Van N.M., Boeke A.J.P., and Lips P. Vitamin D deficiency and neuromuscular performance in the Longitudinal Ading Study Amsterdam (LASA). JBMR 20 Suppl. 1 (2005) S35 abstract 1134
33. Bischoff-Ferrari H.A., Dawson-Hughes B., Willett C.W., et al. Effect of Vitamin D on falls: a meta-analysis. JAMA 291 16 (2004) 1999-2006
34. Pfeifer M., Begerow B., Minne H.W., Abrams C., Nachtigall D., and Hansen C. Effects of a short-term Vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J. Bone Miner. Res. 15 6 (2000) 1113-1118
35. Gallagher J.C., Fowler S.E., Detter J.R., and Sherman S.S. Combination treatment with estrogen and calcitriol in the prevention of age-related bone loss. J. Clin. Endocrinol. Metab. 86 8 (2001) 3618-3628
36. Dukas L., Bischoff H.A., Lindpaintner L.S., et al. Alfacalcidol reduces the number of fallers in a community-dwelling elderly population with a minimum calcium intake of more than 500 mg daily. J. Am. Geriatr. Soc. 52 2 (2004) 230-236
37. Graafmans W.C., Ooms M.E., Hofstee H.M., Bezemer P.D., Bouter L.M., and Lips P. Falls in the elderly: a prospective study of risk factors and risk profiles. Am. J. Epidemiol. 143 11 (1996) 1129-1136
38. Bischoff-Ferrari H.A., Orav E.J., and Dawson-Hughes B. Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Arch. Intern. Med. 166 4 (2006) 424-430
39. Flicker L., MacInnis R.J., Stein M.S., et al. Should older people in residential care receive Vitamin D to prevent falls? Results of a randomized trial. J. Am. Geriatr. Soc. 53 11 (2005) 1881-1888
40. Bischoff-Ferrari H.A., Willett W.C., Wong J.B., Giovannucci E., Dietrich T., and Dawson-Hughes B. Fracture prevention with Vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 293 18 (2005) 2257-2264
41. Lips P., Duong T., Oleksik A., et al. A global study of Vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J. Clin. Endocrinol. Metab. 86 3 (2001) 1212-1221
42. Kinyamu H.K., Gallagher J.C., Balhorn K.E., Petranick K.M., and Rafferty K.A. Serum Vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes. Am. J. Clin. Nutr. 65 3 (1997) 790-797
43. Holick M.F., Shao Q., Liu W.W., and Chen T.C. The Vitamin D content of fortified milk and infant formula. N. Engl. J. Med. 326 18 (1992) 1178-1181
44. Grant A.M., Avenell A., Campbell M.K., et al. Oral Vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or Vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365 9471 (2005) 1621-1628
45. Jackson R.D., LaCroix A.Z., Gass M., et al. Calcium plus Vitamin D supplementation and the risk of fractures. N. Engl. J. Med. 354 7 (2006) 669-683
46. Giovannucci E., Liu Y., Rimm E.B., et al. Prospective study of predictors of Vitamin D status and cancer incidence and mortality in men. J. Natl. Cancer Inst. 98 7 (2006) 451-459
47. Proceedings of the Vitamin D Workshop 2004. J. Steroid Biochem. Mol. Biol. 97 1/2 (2005) 1-2 Epub 2005 October 20
48. Heaney R.P. The Vitamin D requirement in health and disease. J. Steroid Biochem. Mol. Biol. 15 (2005) 15
49. Bouillon R., Moody T., Sporn M., Barrett J.C., and Norman A.W. NIH deltanoids meeting on Vitamin D and cancer. Conclusion and strategic options. J. Steroid Biochem. Mol. Biol. 97 1/2 (2005) 3-5 Epub 2005 July 25
50. Giovannucci E. The epidemiology of Vitamin D and colorectal cancer: recent findings. Curr. Opin. Gastroenterol. 22 1 (2006) 24-29
51. Feskanich D., Ma J., Fuchs C.S., et al. Plasma vitamin d metabolites and risk of colorectal cancer in women. Cancer Epidemiol. Biomarkers Prev. 13 9 (2004) 1502-1508
52. Heaney R.P., Davies K.M., Chen T.C., Holick M.F., and Barger-Lux M.J. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am. J. Clin. Nutr. 77 1 (2003) 204-210
53. Chel V.G., Ooms M.E., Popp-Snijders C., et al. Ultraviolet irradiation corrects Vitamin D deficiency and suppresses secondary hyperparathyroidism in the elderly. J. Bone Miner. Res. 13 8 (1998) 1238-1242
54. Vieth R., Kimball S., Hu A., and Walfish PG. Randomized comparison of the effects of the Vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutr. J. 3 (2004) 8
55. Tangpricha V., Pearce E.N., Chen T.C., and Holick M.F. Vitamin D insufficiency among free-living healthy young adults. Am. J. Med. 112 (2002) 659-662
56. Barger-Lux M.J., Heaney R.P., Dowell S., Chen T.C., and Holick M.F. Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Osteoporos. Int. 8 3 (1998) 222-230
57. Dawson-Hughes B. Impact of Vitamin D and calcium on bone and mineral metabolism in older adults. In: Holick M.F. (Ed). Biologic Effects of Light vol. 20 (2002), Kluwer Academic Publishers, Boston, MA 175-183
58. Vieth R., Chan P.C., and MacFarlane G.D. Efficacy and safety of Vitamin D3 intake exceeding the lowest observed adverse effect level. Am. J. Clin. Nutr. 73 2 (2001) 288-294
59. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride (1997), National Academy Press, Washington, DC
60. Haddock L., Corcino J., and Vazquez M.D. 25(OH)D serum levels in the normal Puerto Rican population and in subjects with tropical sprue and paratyroid disease. Puerto Rico Health Sci. J. 1 (1982) 85-91
61. Haddad J.G., and Chyu K.J. Competitive protein-binding radioassay for 25-hydroxycholecalciferol. J. Clin. Endocrinol. Metab. 33 6 (1971) 992-995
62. Gertner J.M., and Domenech M. 25-Hydroxyvitamin D levels in patients treated with high-dosage ergo- and cholecalciferol. J. Clin. Pathol. 30 2 (1977) 144-150
63. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am. J. Clin. Nutr. 69 5 (1999) 842-856
64. Trivedi D.P., Doll R., and Khaw K.T. Effect of four monthly oral Vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 326 7387 (2003) 469