메뉴 건너뛰기




Volumn 42, Issue 4-5, 2009, Pages 380-386

Association of parental hyperhomocysteinemia and C677T Methylene tetrahydrofolate reductase (MTHFR) polymorphism with recurrent pregnancy loss

Author keywords

DNA damage; Homocysteine; Methylene tetrahydrofolate reductase; Polymorphism; Recurrent pregnancy loss

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

EID: 61449135006     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2008.12.003     Document Type: Article
Times cited : (63)

References (42)
  • 1
    • 0022511654 scopus 로고
    • Characteristics of women with recurrent spontaneous abortions and women with favourable reproductive histories
    • Strobino B., Fox H.E., Kline J., Stein Z., Susser M., and Warburton D. Characteristics of women with recurrent spontaneous abortions and women with favourable reproductive histories. Am. J. Public Health 76 8 (1982) 986-991
    • (1982) Am. J. Public Health , vol.76 , Issue.8 , pp. 986-991
    • Strobino, B.1    Fox, H.E.2    Kline, J.3    Stein, Z.4    Susser, M.5    Warburton, D.6
  • 2
    • 0027330937 scopus 로고
    • Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss
    • Wouters M.G., Boers G.H., Blom H.J., et al. Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil. Steril. 60 5 (1993) 820-825
    • (1993) Fertil. Steril. , vol.60 , Issue.5 , pp. 820-825
    • Wouters, M.G.1    Boers, G.H.2    Blom, H.J.3
  • 3
    • 0037295535 scopus 로고    scopus 로고
    • Homocysteine is embryotoxic but does not cause neural tube defects in mouse embryos
    • (Berl)
    • Greene N.D., Dunlevy L.E., and Copp A.J. Homocysteine is embryotoxic but does not cause neural tube defects in mouse embryos. Anat. Embryol 206 3 (2003) 185-191 (Berl)
    • (2003) Anat. Embryol , vol.206 , Issue.3 , pp. 185-191
    • Greene, N.D.1    Dunlevy, L.E.2    Copp, A.J.3
  • 4
    • 0030728675 scopus 로고    scopus 로고
    • Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats
    • Durand P., Lussier-Cacan S., and Blache D. Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats. FASEB J. 11 13 (1997) 1157-1168
    • (1997) FASEB J. , vol.11 , Issue.13 , pp. 1157-1168
    • Durand, P.1    Lussier-Cacan, S.2    Blache, D.3
  • 5
    • 0027319970 scopus 로고
    • Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
    • Nishinaga M., Ozawa T., and Shimada K. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells. J. Clin. Invest. 92 3 (1993) 1381-1386
    • (1993) J. Clin. Invest. , vol.92 , Issue.3 , pp. 1381-1386
    • Nishinaga, M.1    Ozawa, T.2    Shimada, K.3
  • 6
    • 33847171027 scopus 로고    scopus 로고
    • Increase in S-adenosylhomocysteine content and its effect on the S-adenosylhomocysteine hydrolase activity under transient high plasma homocysteine levels in rats
    • (Tokyo)
    • Isa Y., Mishima T., Tsuge H., and Hayakawa T. Increase in S-adenosylhomocysteine content and its effect on the S-adenosylhomocysteine hydrolase activity under transient high plasma homocysteine levels in rats. J. Nutr. Sci. Vitaminol. 52 6 (2006) 479-482 (Tokyo)
    • (2006) J. Nutr. Sci. Vitaminol. , vol.52 , Issue.6 , pp. 479-482
    • Isa, Y.1    Mishima, T.2    Tsuge, H.3    Hayakawa, T.4
  • 7
    • 0031410993 scopus 로고    scopus 로고
    • Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men
    • Fenech M.F., Dreosti I.E., and Rinaldi J.R. Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis 18 7 (1997) 1329-1336
    • (1997) Carcinogenesis , vol.18 , Issue.7 , pp. 1329-1336
    • Fenech, M.F.1    Dreosti, I.E.2    Rinaldi, J.R.3
  • 8
    • 0033854582 scopus 로고    scopus 로고
    • Increased micronuclei frequencies in couples with reproductive failure
    • Trkova M., Kapras J., Bobkova K., Stankova J., and Mejsnarova B. Increased micronuclei frequencies in couples with reproductive failure. Reprod. Toxicol. 14 4 (2000) 331-335
    • (2000) Reprod. Toxicol. , vol.14 , Issue.4 , pp. 331-335
    • Trkova, M.1    Kapras, J.2    Bobkova, K.3    Stankova, J.4    Mejsnarova, B.5
  • 9
    • 0031961002 scopus 로고    scopus 로고
    • A worldwide distribution of a common MTHFR Mutation
    • Schneider J.A., Rees D.C., Liu Y.T., et al. A worldwide distribution of a common MTHFR Mutation. Am. J. Hum. Genet. 62 5 (1998) 1258-1260
    • (1998) Am. J. Hum. Genet. , vol.62 , Issue.5 , pp. 1258-1260
    • Schneider, J.A.1    Rees, D.C.2    Liu, Y.T.3
  • 10
    • 4444224055 scopus 로고    scopus 로고
    • Prevalence of methylene tetrahydrofolate reductase polymorphism in South Indian population
    • Radha Rama Devi A., Govindaiah V., Ramakrishna G., and Naushad S.M. Prevalence of methylene tetrahydrofolate reductase polymorphism in South Indian population. Curr. Sci. 86 3 (2004) 440-443
    • (2004) Curr. Sci. , vol.86 , Issue.3 , pp. 440-443
    • Radha Rama Devi, A.1    Govindaiah, V.2    Ramakrishna, G.3    Naushad, S.M.4
  • 11
    • 0030637784 scopus 로고    scopus 로고
    • The relationship between maternal nutritional status and spontaneous abortion
    • Neela J., and Raman L. The relationship between maternal nutritional status and spontaneous abortion. Natl. Med. J. India 10 1 (1997) 15-16
    • (1997) Natl. Med. J. India , vol.10 , Issue.1 , pp. 15-16
    • Neela, J.1    Raman, L.2
  • 12
    • 0034934781 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians
    • Refsum H., Yajnik C.S., Gadkari M., et al. Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. Am. J. Clin. Nutr. 74 2 (2001) 233-241
    • (2001) Am. J. Clin. Nutr. , vol.74 , Issue.2 , pp. 233-241
    • Refsum, H.1    Yajnik, C.S.2    Gadkari, M.3
  • 13
    • 0025848779 scopus 로고
    • Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum
    • Ubbink J.B., Hayward Vermaak W.J., and Bissbort S. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J. Chromatogr. 565 1-2 (1991) 441-446
    • (1991) J. Chromatogr. , vol.565 , Issue.1-2 , pp. 441-446
    • Ubbink, J.B.1    Hayward Vermaak, W.J.2    Bissbort, S.3
  • 14
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Frosst P., Blom H.J., Milos R., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat. Genet. 10 1 (1995) 111-113
    • (1995) Nat. Genet. , vol.10 , Issue.1 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 15
    • 0025079311 scopus 로고
    • Micronuclei assay in cytokinesis-blocked binucleated and conventional mononucleated methods in human peripheral lymphocytes
    • Nath C.J., and Ong T. Micronuclei assay in cytokinesis-blocked binucleated and conventional mononucleated methods in human peripheral lymphocytes. Teratog. Carcinog. Mutagen. 10 3 (1990) 273-279
    • (1990) Teratog. Carcinog. Mutagen. , vol.10 , Issue.3 , pp. 273-279
    • Nath, C.J.1    Ong, T.2
  • 16
    • 0032055364 scopus 로고    scopus 로고
    • Oral estrogen improves serum lipids, homocysteine and fibrinolysis in elderly men
    • Giri S., Thompson P.D., Taxel P., et al. Oral estrogen improves serum lipids, homocysteine and fibrinolysis in elderly men. Atherosclerosis 137 (1998) 359-366
    • (1998) Atherosclerosis , vol.137 , pp. 359-366
    • Giri, S.1    Thompson, P.D.2    Taxel, P.3
  • 17
    • 0031017946 scopus 로고    scopus 로고
    • Cortisol and estradiol: non-genetic factors for hyperhomocyst(e)inemia
    • Kim M.H., Kim E., Passon E.L., et al. Cortisol and estradiol: non-genetic factors for hyperhomocyst(e)inemia. Metabolism 46 (1997) 247-249
    • (1997) Metabolism , vol.46 , pp. 247-249
    • Kim, M.H.1    Kim, E.2    Passon, E.L.3
  • 18
    • 0028600627 scopus 로고
    • Homocysteine and cysteine: Determinants of plasma levels in middle-aged and elderly subjects
    • Brattstrom L., Lindgren A., Israelsson B., Andersson A., and Hultberg B. Homocysteine and cysteine: Determinants of plasma levels in middle-aged and elderly subjects. J. Inter-Am. Med. 236 6 (1994) 633-641
    • (1994) J. Inter-Am. Med. , vol.236 , Issue.6 , pp. 633-641
    • Brattstrom, L.1    Lindgren, A.2    Israelsson, B.3    Andersson, A.4    Hultberg, B.5
  • 21
    • 0034879133 scopus 로고    scopus 로고
    • Linear increase of diploidy in human sperm with age: a four-colour FISH study
    • Bosch M., Rajmil O., Martinez-Pasarell O., et al. Linear increase of diploidy in human sperm with age: a four-colour FISH study. Eur. J. Hum. Genet. 9 (2001) 533-538
    • (2001) Eur. J. Hum. Genet. , vol.9 , pp. 533-538
    • Bosch, M.1    Rajmil, O.2    Martinez-Pasarell, O.3
  • 22
    • 0028792586 scopus 로고
    • Non-disjunction in human sperm: evidence for an effect of increasing paternal age
    • Griffin D.K., Abruzzo M.A., Millie E.A., et al. Non-disjunction in human sperm: evidence for an effect of increasing paternal age. Hum. Mol. Genet. 4 (1995) 2227-2232
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 2227-2232
    • Griffin, D.K.1    Abruzzo, M.A.2    Millie, E.A.3
  • 23
    • 0346849777 scopus 로고    scopus 로고
    • Effects of age on DNA double-strand breaks and apoptosis in human sperm
    • Singh N.P., Muller C.H., and Berger R.E. Effects of age on DNA double-strand breaks and apoptosis in human sperm. Fertil. Steril. 80 (2003) 1420-1430
    • (2003) Fertil. Steril. , vol.80 , pp. 1420-1430
    • Singh, N.P.1    Muller, C.H.2    Berger, R.E.3
  • 24
    • 0034303523 scopus 로고    scopus 로고
    • The origins, patterns and implications of human spontaneous abortion
    • Crow J. The origins, patterns and implications of human spontaneous abortion. Nat. Rev., Genet. 1 (2000) 40-47
    • (2000) Nat. Rev., Genet. , vol.1 , pp. 40-47
    • Crow, J.1
  • 25
    • 0031883045 scopus 로고    scopus 로고
    • A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages
    • Quere I., Bellet H., Hoffet M., Janbon C., Mares P., and Gris J.C. A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages. Fertil. Steril. 69 1 (1998) 152-154
    • (1998) Fertil. Steril. , vol.69 , Issue.1 , pp. 152-154
    • Quere, I.1    Bellet, H.2    Hoffet, M.3    Janbon, C.4    Mares, P.5    Gris, J.C.6
  • 27
    • 0034108583 scopus 로고    scopus 로고
    • Maternal homocysteine and chorionic vascularization in recurrent early pregnancy loss
    • Nelen W.L., Bulten J., Steegers E.A., Blom H.J., Hanselaar A.G., and Eskes T.K. Maternal homocysteine and chorionic vascularization in recurrent early pregnancy loss. Hum. Reprod. 15 4 (2000) 954-960
    • (2000) Hum. Reprod. , vol.15 , Issue.4 , pp. 954-960
    • Nelen, W.L.1    Bulten, J.2    Steegers, E.A.3    Blom, H.J.4    Hanselaar, A.G.5    Eskes, T.K.6
  • 28
    • 0033638057 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis
    • Nelen W.L., Blom H.J., Steegers E.A., den Heijer M., and Eskes T.K. Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis. Fertil. Steril. 74 6 (2000) 1196-1199
    • (2000) Fertil. Steril. , vol.74 , Issue.6 , pp. 1196-1199
    • Nelen, W.L.1    Blom, H.J.2    Steegers, E.A.3    den Heijer, M.4    Eskes, T.K.5
  • 29
    • 33751186905 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism and the risk of unexplained recurrent pregnancy loss: a meta-analysis
    • Ren A., and Wang J. Methylenetetrahydrofolate reductase C677T polymorphism and the risk of unexplained recurrent pregnancy loss: a meta-analysis. Fertil. Steril. 86 6 (2006) 1716-1722
    • (2006) Fertil. Steril. , vol.86 , Issue.6 , pp. 1716-1722
    • Ren, A.1    Wang, J.2
  • 30
    • 85047696639 scopus 로고    scopus 로고
    • Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos
    • Zetterberg H., Regland B., Palmér M., et al. Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos. Eur. J. Hum. Genet. 10 2 (2002) 113-118
    • (2002) Eur. J. Hum. Genet. , vol.10 , Issue.2 , pp. 113-118
    • Zetterberg, H.1    Regland, B.2    Palmér, M.3
  • 31
    • 0037258565 scopus 로고    scopus 로고
    • Plasma homocysteine levels correlated to interactions between folate status and methylene tetrahydrofolate reductase gene mutation in women with unexplained recurrent pregnancy loss
    • Kumar K.S., Govindaiah V., Naushad S.E., Devi R.R., and Jyothy A. Plasma homocysteine levels correlated to interactions between folate status and methylene tetrahydrofolate reductase gene mutation in women with unexplained recurrent pregnancy loss. J. Obstet. Gynaecol. 23 1 (2003) 55-58
    • (2003) J. Obstet. Gynaecol. , vol.23 , Issue.1 , pp. 55-58
    • Kumar, K.S.1    Govindaiah, V.2    Naushad, S.E.3    Devi, R.R.4    Jyothy, A.5
  • 32
    • 0042354172 scopus 로고    scopus 로고
    • Clinical B12 deficiency in one case of recurrent spontaneous pregnancy loss
    • Candito M., Magnaldo S., Bayle J., et al. Clinical B12 deficiency in one case of recurrent spontaneous pregnancy loss. Clin. Chem. Lab. Med. 41 8 (2003) 1026-1027
    • (2003) Clin. Chem. Lab. Med. , vol.41 , Issue.8 , pp. 1026-1027
    • Candito, M.1    Magnaldo, S.2    Bayle, J.3
  • 33
    • 34547746861 scopus 로고    scopus 로고
    • Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report
    • D'Uva M., Di Micco P., Strina I., et al. Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report. Thromb. J. 11 (2007) 5-10
    • (2007) Thromb. J. , vol.11 , pp. 5-10
    • D'Uva, M.1    Di Micco, P.2    Strina, I.3
  • 34
    • 79961176317 scopus 로고    scopus 로고
    • Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss
    • Carrell D.T., Liu L., Peterson C.M., et al. Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss. Arch. Androl. 49 1 (2003) 49-55
    • (2003) Arch. Androl. , vol.49 , Issue.1 , pp. 49-55
    • Carrell, D.T.1    Liu, L.2    Peterson, C.M.3
  • 35
    • 0038209030 scopus 로고    scopus 로고
    • Elevated sperm chromosome aneuploidy and apoptosis in patients with unexplained recurrent pregnancy loss
    • Carrell D.T., Wilcox A.L., Lowy L., et al. Elevated sperm chromosome aneuploidy and apoptosis in patients with unexplained recurrent pregnancy loss. Obstet. Gynecol. 101 6 (2003) 1229-1235
    • (2003) Obstet. Gynecol. , vol.101 , Issue.6 , pp. 1229-1235
    • Carrell, D.T.1    Wilcox, A.L.2    Lowy, L.3
  • 37
    • 0031828880 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages
    • Nelen W.L., Blom H.J., Thomas C.M., Steegers E.A., Boers G.H., and Eskes T.K. Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. J. Nutr. 128 8 (1998) 1336-1341
    • (1998) J. Nutr. , vol.128 , Issue.8 , pp. 1336-1341
    • Nelen, W.L.1    Blom, H.J.2    Thomas, C.M.3    Steegers, E.A.4    Boers, G.H.5    Eskes, T.K.6
  • 38
    • 0022472013 scopus 로고
    • Activation of endogenous Factor V by a homocysteine-induced vascular endothelial cell activator
    • Rodgers G.M., and Kane W.H. Activation of endogenous Factor V by a homocysteine-induced vascular endothelial cell activator. J. Clin. Invest. 77 6 (1986) 1909-1916
    • (1986) J. Clin. Invest. , vol.77 , Issue.6 , pp. 1909-1916
    • Rodgers, G.M.1    Kane, W.H.2
  • 39
    • 0026345948 scopus 로고
    • Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine
    • Lentz S.R., and Sadler J.E. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J. Clin. Invest. 88 6 (1991) 1906-1914
    • (1991) J. Clin. Invest. , vol.88 , Issue.6 , pp. 1906-1914
    • Lentz, S.R.1    Sadler, J.E.2
  • 40
    • 0027319970 scopus 로고
    • Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
    • Nishinaga M., Ozawa T., and Shimada K. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells. J. Clin. Invest. 92 3 (1993) 1381-1386
    • (1993) J. Clin. Invest. , vol.92 , Issue.3 , pp. 1381-1386
    • Nishinaga, M.1    Ozawa, T.2    Shimada, K.3
  • 41
    • 0032540276 scopus 로고    scopus 로고
    • Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine
    • Hajjar K.A., Mauri L., Jacovina A.T., et al. Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine. J. Biol. Chem. 273 16 (1998) 9987-9993
    • (1998) J. Biol. Chem. , vol.273 , Issue.16 , pp. 9987-9993
    • Hajjar, K.A.1    Mauri, L.2    Jacovina, A.T.3
  • 42
    • 34250187067 scopus 로고    scopus 로고
    • Cytokinesis-block micronucleus cytome assay
    • Fenech M. Cytokinesis-block micronucleus cytome assay. Nat. Protoc. 2 5 (2007) 1084-1104
    • (2007) Nat. Protoc. , vol.2 , Issue.5 , pp. 1084-1104
    • Fenech, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.