A woman with five consecutive fetal deaths: Case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages

Fertility and Sterility

Volumn 69, Issue 1, 1998, Pages 152-154

  Quere, Isabelle ^a   Bellet, Hélène ^a   Hoffet, Méderic ^b   Janbon, Charles ^a   Mares, Pierre ^b   Gris, Jean Christophe ^b,c  

^a HÔPITAL SAINT ELOI   (France)

^b NÎMES UNIVERSITY HOSPITAL   (France)

^c UNIV MONTPELLIER   (France)

Author keywords

Folate; Homocysteine; Methylene tetrahydrofolate reductase; Recurrent miscarriages

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; PYRIDOXINE;

ADULT; ARTICLE; CASE REPORT; DISEASE ASSOCIATION; FEMALE; FETUS DEATH; FOLIC ACID DEFICIENCY; FRANCE; GENE MUTATION; HOMOZYGOSITY; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; PREVALENCE; PRIORITY JOURNAL; RECURRENT ABORTION; RETROSPECTIVE STUDY;

ABORTION, HABITUAL; ADULT; CROSS-SECTIONAL STUDIES; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MUTATION; OSMOLAR CONCENTRATION; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PREGNANCY; PREGNANCY OUTCOME; PYRIDOXINE; REFERENCE VALUES; RETROSPECTIVE STUDIES;

EID: 0031883045     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(97)00451-2     Document Type: Article

References (4)

1. 1. Preston FE, Rosendaal FR, Walker ID, Briët E, Berntorp E, Conard J, et al. Increased fetal loss in women with heritable thrombophilia. N Engl J Med 1996;348:913-6.
2. 2. Heijer MD, Koster T, Blom HJ, Bos GMJ, Briët E, Reitsma PH, et al. Hyperhomocysteinemia as a risk factor for deep vein thrombosis. N Engl J Med 1996;334:759-62.
3. 3. Wouters MGAJ, Boers GHJ, Blom HJ, Trijbels FJM, Thomas CMG, Borm GF, et al. Hyperhomo-cyssteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil Steril 1993;60:820-4.
4. 4. Frosst P, Blom HJ, Milos R, Goyette P, Sheppart CA, Mattews RG. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet 1995;10:111-3.