Maternal homocysteine and chorionic vascularization in recurrent early pregnancy loss

Human Reproduction

Volumn 15, Issue 4, 2000, Pages 954-960

  Nelen, Willianne L D M ^a,c   Bulten, Johan ^a   Steegers, Eric A P ^b   Blom, Henk J ^b   Hanselaar, Antonius G J M ^a   Eskes, Tom K A B ^b  

^a Departments of Obstetrics and Gynecology and Internal Medicine   (Netherlands)

^b Department of Pathology ^*

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Abortion; CD34; Chorionic vascularization; Early pregnancy loss; Homocysteine

Indexed keywords

CD34 ANTIGEN; COBALAMIN; HOMOCYSTEINE;

ADULT; ARTICLE; CHORION VILLUS; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EMBRYO DEATH; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; REVASCULARIZATION; RISK FACTOR; SPONTANEOUS ABORTION;

EID: 0034108583     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/15.4.954     Document Type: Article

References (34)

1. Boushey, C.J., Beresford, S.A.A., Omenn, G.S. et al. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA, 274, 1049-1057.
2. Campbell, J., Wathen, N., Perry, G. et al. (1993) The coelomic cavity: an important site of matemo-fetal nutrient exchange in the first trimester of pregnancy. Br. J. Obstet. Cynaecol., 100, 765-767.
3. Coumans, A.B.C., Huijgens, P.C., Jakobs, C. et al. (1999) Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion. Huin. Reprod., 14,211-214.
4. Craven, CM. and Ward, K. (1999) Syncytiotrophoblastic fragments in first-trimester decidual veins: evidence of placental perfusion by the maternal circulation early in pregnancy. Am. J. Obstet. GynecoL, 181, 455-159.
5. Dekker, O.A., De Vries, J.I., Doelitzsch, P.M. et al. (1995) Underlying disorders associated with severe early-onset preeclampsia. Am. J. Obstet. Gynecol., 173, 1042-1048.
6. Demir, R., Kaufmann, P., Castellucci, M. et al. (1989) Fetal vasculogenesis and angiogenesis in human placental villi. Ada Anal. (Basel), 136, 190-203.
7. Den Heijer, M., Koster, T., Blom, H.J. et al. (1996) Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N. Engl. J. Med., 334, 759-762.
8. Exalto, N. (1995) Early human nutrition. Eur. J. Obstet. Gynecol. Reprod. Biol, 61, 3-6.
9. Goddijn Wessel, T.A., Wouters, M.G.A.J., Van der Molen, E.F. et al. (1996) Hyperhomocysteinemia: a risk factor for placental abruption or infarction. Eur. J. Obstet. Gynecol. Reprod. Biol, 66, 23-29.
10. Graham, I.M., Daly, L.E., Refsum, H.M. et al. (1997) Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA, 277, 1775-1781.
11. Heby, O. (1995) DNA methylation and polyamines in embryonic development and cancer. Int. J. Dev. Biol, 39, 737-757.
12. Hustin, J. and Schaaps, J.P. (1987) Echographic and anatomic studies of the maternotrophoblastic border during the first trimester of pregnancy. Am. J. Obstet. Gynecol, 157, 162-168.
13. Meegdes, B.H., Ingenhoes, R., Peelers, L.L. et al. (1988) Early pregnancy wastage: relationship between chorionic vascularization and embryonic development. Fertil. Steril., 49, 216-220.
14. Mooij, P.N., Thomas, C.M.G., Doesburg, W.H. et al. (1991) Multivitamin supplementation in oral contraceptive users. Contraception, 44, 277-288.
15. Nelen, W.L.D.M., Steegers, E.A.P., Eskes, T.K.A.B. et al. (1997a) Genetic risk factor for unexplained recurrent early pregnancy loss. Lancet, 350, 861.
16. Nelen, W.L.D.M., Van der Molen, E.F., Blom, H.J. et al. (1997b) Recurrent early pregnancy loss and genetic-related disturbances in folate and homocysteine metabolism. Br. J. Hasp. Med., 58, 511-513.
17. Nelen, W.L.D.M., Blom, H.J., Thomas, C.M.G. et al. (1998) Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. J.Nulr., 128, 1336-1341.
18. Nelen, W.L.D.M., Blom, H.J., Steegers, E.A.P. et al. (2000) Homocysteine and folate levels as risk factors for recurrent early pregnancy loss. Obstet. Gynecol. (in press).
19. Obwegeser, R., Hohlagschwandtner, M. and Sinzinger, H. (1999) Homocysteine - a pathophysiological cornerstone in obstetrical and gynaecological disorders? Hum. Reprod. Update, 5, 64-72.
20. Quere, I., Bellet, H., Hoffet, M. et al (1998) A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages. Fertil. Steril, 69, 152-154.
21. Rehder, H., Coerdt, W., Eggers, R. et al. (1989) Is there a correlation between morphological and cytogenetic findings in placental tissue from early missed abortions? Hum. Genet., 82, 377-385.
22. Rockelein, G., Ulmer, R. and Schroder, J. (1991) Karyotype and placental structure of first-trimester spontaneous abortions: a morphometrical study. Eur. J. Obstet. Gynecol. Reprod. Biol, 38, 25-32.
23. Rodesch, E, Simon, P., Donner, C. et al. (1992) Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy. Obstet. Gynecol, 80, 283-285.
24. Salafia, C., Maier, D., Vogel, C. et al. (1993) Placental and decidual histology in spontaneous abortion: detailed description and correlations with chromosome number. Obstet. Gynecol, 82, 295-303.
25. Schrijver, J., Speek, A.J. and Schreurs, W.H. (1981) Semi-automated fluorometric determination of pyridoxal-5′-phosphate (vitamin B6) in whole blood by high-performance liquid chromatography (HPLC). Int. J. Vitam. Nutr. Res., 51, 216-222.
26. Steegers-Theunissen, R.P.M., Boers, G.H.J., Blom, H.J. et al. (1992) Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. Lancet, 339, 1122-1123.
27. Steegers-Theunissen, R.P.M., Boers, G.H.J., Trijbels, F.J.M. et al. (1994) Maternal hyperhomocysteinemia: a risk factor for neural-tube defects? Metabolism, 43, 1475-1480.
28. Steegers-Theunissen, R.P.M., Wathen, N.C., Eskes, T.K.A.B. et al. (1997) Maternal and fetal levels of methionine and homocysteine in early human pregnancy. Br. J. Obstet. Gynaecol, 104, 20-24.
29. Te Poele-Pothoff, M.T., Van den Berg, M., Franken, D.G. et al (1995) Three different methods for the determination of total homocysteine in plasma. Ann. Clin. Biochem., 32, 218-220.
30. te Velde, E.A., Exalto, N., Hesseling, P. et al. (1997) First trimester development of human chorionic villous vascularization studied with CD34 immunohistochemistry. Hum. Reprod., 12, 1577-1581.
31. Vailhe, B., Dietl, J., Kapp, M. et al. (1999) Increased blood vessel density in decidua parietalis is associated with spontaneous human first trimester abortion. Hum. Reprod., 14, 1628-1634.
32. Valentin, L., Sladkevicius, P., Laurini, R. et al. (1996) Uteroplacental and luteal circulation in normal first-trimester pregnancies: Doppler ultrasonographic and morphologic study. Am. J. Obstet. Gynecol, 174, 768-775.
33. Weidner, N. (1995) Intratumor microvessel density as a prognostic factor in cancer. Am. J. Pathol, 147, 9-19.
34. Wouters, M.G.A.J., Boers, G.H.J., Blom, H.J. et al (1993) Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil. Steril., 60, 820-825.