Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed kaposi's sarcoma-associated herpesvirus Kaposin protein

Journal of Infectious Diseases

Volumn 184, Issue 2, 2001, Pages 119-126

  Brander, Christian ^a   O'Connor, Paula ^a   Suscovich, Todd ^a   Jones, Norman G ^a   Lee, Yun ^a   Kedes, Dean ^b   Ganem, Don ^c   Martin, Jeff ^d   Osmond, Dennis ^d   Southwood, Scott ^e   Sette, Alessandro ^e   Walker, Bruce D ^a   Scadden, David T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Epimmune   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GENE PRODUCT; KAPOSIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HERPES VIRUS; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; KAPOSI SARCOMA; MONONUCLEAR CELL; NONHUMAN; OPEN READING FRAME; PEPTIDE ANALYSIS; PRIORITY JOURNAL; RNA VIRUS; SEQUENCE ANALYSIS; VIRUS REPLICATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; EPITOPES; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 8, HUMAN; HLA-A ANTIGENS; HUMANS; T-LYMPHOCYTES, CYTOTOXIC; VIRAL PROTEINS;

EID: 0035879820     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/322003     Document Type: Article

References (42)

1. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
2. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)
3. Kaposi's sarcoma-associated herpesvirus: A lymphotropic human herpesvirus associated with Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease
4. Human cytotoxic T lymphocyte responses to Epstein-Bart virus infection
5. Pathogenesis of cytomegalovirus pneumonia in immunocompromised hosts
6. Identification of human herpesvirus 8-specific cytotoxic T-cell responses
7. + cytotoxic T lymphocyte responses to lytic proteins of human herpes virus 8 in human immunodeficiency virus type 1-infected and -uninfected individuals
8. MHC molecules as peptide receptors
9. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
10. Recent advances in HIV-1 CTL epitope characterization
11. Two complementary methods for predicting peptides binding major histocompatibility complex molecules
12. MHC ligands and peptide motifs: First listing
13. Hepatitis C virus infection in sexually active homosexual men
14. Sexual transmission and the natural history of human herpesvirus 8 infection
15. Selected sexual practices of San Francisco heterosexual men and risk of infection by the human immunodeficiency virus
16. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcom-associated herpesvirus): Distribution of infection in KS risk groups and evidence for sexual transmission
17. Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted CTL response in chronic HIV-1 infection
18. HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals
19. Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays
20. The relationship between class 1 binding affinity and immunogenicity of potential cytotoxic T cell epitopes
21. Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigen (HLA)-identical siblings with HLAA0201 are influenced by epitope mutation
22. Persistent HIV-1 specific CTL clonal expansion despite high viral burden post in-utero HIV-1 infection
23. Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma
24. A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus
25. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
26. Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin's disease
27. Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children
28. Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin's disease
29. + T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained
30. Viral immune evasion due to persistence of activated T cells without effector function
31. Human herpesvirus 8 cellular immune responses in homosexual men
32. Impaired CTL recognition of cells latently infected with Kaposi's sarcoma associated herpes virus (KSHV/ HHV8)
33. Modulation of the host immune response by clinically relevant human DNA and RNA viruses
34. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis
35. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins
36. Strain variability among Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genomes: Evidence that a large cohort of United States AIDS patients may have been infected by a single common isolate
37. + T cell response: Lessons from the EBV nuclear antigen EBNA1
38. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi
39. Primary proliferative and cytotoxic T-cell responses to HIV induced in vitro by human dendritic cells
40. HIV-1-specific CTL responses primed in vitro by blood-derived dendritic cells and Th1-biasing cytokines
41. + T lymphocyte responses in vitro using dendritic cells