2D- and 3D-QSAR of Tocainide and Mexiletine analogues acting as Nav1.4 channel blockers

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1477-1485

  Carrieri, Antonio ^a   Muraglia, Marilena ^a   Corbo, Filomena ^a   Pacifico, Concetta ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

3D QSAR; GRIND; Mexiletine; Sodium channel; Tocainide

Indexed keywords

2 (BENZYLAMINO) N (2,6 DIMETHYLPHENYL)PROPANAMIDE; MEXILETINE; SODIUM CHANNEL BLOCKING AGENT; TOCAINIDE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; IN VITRO STUDY; INHIBITION KINETICS; LIPOPHILICITY; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

CRYSTALLOGRAPHY, X-RAY; MEXILETINE; PROTEIN ISOFORMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SUBSTRATE SPECIFICITY; TOCAINIDE;

EID: 61349189631     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.10.005     Document Type: Article

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