Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity

Journal of Medicinal Chemistry

Volumn 43, Issue 20, 2000, Pages 3792-3798

  Franchini, C ^a   Corbo, F ^a   Lentini, G ^a   Bruno, G ^a   Scilimati, A ^a   Tortorella, V ^a   Camerino, D C ^a   De Luca, A ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

N (2,6 DIMETHYLPHENYL) 1 METHYL 2 PYRROLIDINECARBOXAMIDE; N (2,6 DIMETHYLPHENYL) 2 PYRROLIDINECARBOXAMIDE; N (2,6 DIMETHYLPHENYL) N METHYL 2 PYRROLIDINECARBOXAMIDE; N (2,6 DIMETHYLPHENYL) N,1 DIMETHYL 2 PYRROLIDINECARBOXAMIDE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TOCAINIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; HYDROGEN BOND; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ION CHANNEL GATING; MUSCLE FIBERS; MUSCLE, SKELETAL; PATCH-CLAMP TECHNIQUES; PYRROLIDINES; RANIDAE; SODIUM CHANNELS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOCAINIDE;

EID: 0034609854     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000931l     Document Type: Article

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