Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers

Journal of Heterocyclic Chemistry

Volumn 44, Issue 5, 2007, Pages 1099-1103

  Muraglia, Marilena ^a   Franchini, Carlo ^a   Corbo, Filomena ^a   Scilimati, Antonio ^a   Sinicropi, Maria Stefania ^b   De Luca, Annamaria ^a   De Bellis, Michela ^a   Camerino, Diana Conte ^a   Tortorella, Vincenzo ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL N (2,6 DIMETHYLPHENYL) 3 PYRROLIDINE CARBOXAMIDE; BETA PROLINE DERIVATIVE; PROLINE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG ACTIVITY; DRUG SYNTHESIS; OPTICAL ROTATION; REACTION ANALYSIS;

EID: 36648999017     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570440519     Document Type: Article

References (15)

1. Rudel, R.; Lehmann-Horn, F.; Ricker, K.; In Engel, A. G.; Franzini-Armstrong, C. Myology, McGraw-Hill. Ed., Pergamon Press: New York, 1994, pp 1291-1302.
2. Ptacek, L. Am. J. Med. 1998, 104, 58.
3. Kwiecinski, H.; Ryniewicz, B.; Ostrzycki, A. Acta Neurol. Scand. 1992, 86, 371.
4. Catterall, W. A. Trends Pharmacol. Sci. 1987, 8, 57.
5. De Luca, A.; Natuzzi, F.; Duranti, A.; Lentini, G.; Franchini, C.; Tortorella, V.; Conte Camerino, D. Naunyn-Schmiedberg's Arch. Pharmacol. 1997, 356, 777.
6. Hille, B. J. Gen. Physiol. 1977, 69, 497.
7. Franchini, C.; Corbo, F.; Lentini, G.; Bruno, G.; Scilimati, A.; Tortorella, V.; Conte Camerino, D.; De Luca, A. J. Med. Chem. 2000, 43, 3792.
8. Ma, Z.; Chu, D. T. W.; Cooper, C. S.; Li, Q.; Fung, A. K. L.; Wang, S.; Shen, L. L.; Flamm, R. K.; Nilius, A. M.; Alder, J. D.; Meulbroek, J. A.; Or, Y. S. J. Med. Chem. 1999, 42, 4202.
9. Catto, A.; Motta, G.; Tajana, A.; Cazzaluni, P.; Nardi, D.; Leonardi, A. J. Med. Chem. 1987, 30, 13.
10. Terao, Y.; Kotaki, H.; Imai, N.; Achiwa, K. Chem. Pharm. Bull. 1985, 33, 2762.
11. Scilimati, A.; Franchini, C.; Tortorella, V.; Corbo, F.; Lentini, G.; Conte Camerino, D.; De Luca, A. Italian Patent MI2001A 000085 2001.
12. Thomas, C.; Orecher, F.; Gmeiner, P. Synthesis 1998, 33, 1491.
13. Talon, S.; De Luca, A.; De Bellis, M.; Desaphy, J-F.; Lentini, G.; Scilimati, A.; Corbo, F.; Franchini, C.; Tortorella, P.; Jockusch, H.; Conte-Camerino, D. Brit. J. Pharmacol. 2001, 134, 1523.
14. De Luca, A.; Talon, S.; De Bellis, M.; Desaphy, J.F.; Lentini, G.; Corbo, F.; Scilimati, A.; Franchini, C.; Tortorella, V.; Conte Camerino, D. Mol. Pharmacol. 2003, 64(4), 932.
15. Still, W. C.; Kahn, M.; Mitra, J. Org. Chem. 1978, 43, 2923.