Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions

Neuroscience

Volumn 159, Issue 2, 2009, Pages 610-617

  Silberstein, S ^a   Vogl, A M ^b   Refojo, D ^b   Senin, S A ^a   Wurst, W ^b,c   Holsboer, F ^b   Deussing, J M ^b   Arzt, E ^a  

^a INSTITUTO DE FISIOLOGÍA   (Argentina)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

CRF; CRH; CRH receptor; ERK; HPA axis

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ACUTE STRESS; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMPHIBIAN PROTEINS; AMYGDALA; ANIMALS; AUTORADIOGRAPHY; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IODINE ISOTOPES; MALE; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 3; PEPTIDE HORMONES; PROTEIN BINDING; RADIOIMMUNOASSAY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RESTRAINT, PHYSICAL; STRESS, PSYCHOLOGICAL; TIME FACTORS;

EID: 61349189527     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.01.014     Document Type: Article

References (57)

1. Ailing F., Fan L., Li S., and Manji S. Role of extracellular signal-regulated kinase signal transduction pathway in anxiety. J Psychiatr Res 43 (2008) 55-63
2. Arborelius L., Owens M.J., Plotsky P.M., and Nemeroff C.B. The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol 160 (1999) 1-12
3. Arzt E., and Holsboer F. CRF signaling: molecular specificity for drug targeting in the CNS. Trends Pharmacol Sci 27 (2006) 531-538
4. Bale T.L., and Vale W.W. CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol 44 (2004) 525-557
5. Bayatti N., Zschocke J., and Behl C. Brain region-specific neuroprotective action and signaling of corticotropin-releasing hormone in primary neurons. Endocrinology 144 (2003) 4051-4060
6. Bittencourt J.C., and Sawchenko P.E. Do centrally administered neuropeptides access cognate receptors?. An analysis in the central corticotropin-releasing factor system. J Neurosci 20 (2000) 1142-1156
7. Chalmers D.T., Lovenberg T.W., and De Souza E.B. Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. J Neurosci 15 (1995) 6340-6350
8. Chen Y., Brunson K.L., Muller M.B., Cariaga W., and Baram T.Z. Immunocytochemical distribution of corticotropin-releasing hormone receptor type-1 (CRF(1))-like immunoreactivity in the mouse brain: light microscopy analysis using an antibody directed against the C-terminus. J Comp Neurol 420 (2000) 305-323
9. Dagerlind A., Friberg K., Bean A.J., and Hokfelt T. Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry 98 (1992) 39-49
10. de Kloet E.R., Joels M., and Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci 6 (2005) 463-475
11. Di Benedetto B., Hitz C., Holter S.M., Kuhn R., Vogt Weisenhorn D.M., and Wurst W. Differential mRNA distribution of components of the ERK/MAPK signalling cascade in the adult mouse brain. J Comp Neurol 500 (2007) 542-556
12. Dunn A.J., and Berridge C.W. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?. Brain Res Brain Res Rev 15 (1990) 71-100
13. Dwivedi Y., Rizavi H.S., Roberts R.C., Conley R.C., Tamminga C.A., and Pandey G.N. Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects. J Neurochem 77 (2001) 916-928
14. Einat H., Yuan P., Gould T.D., Li J., Du J., Zhang L., Manji H.K., and Chen G. The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. J Neurosci 23 (2003) 7311-7316
15. Flood D.G., Finn J.P., Walton K.M., Dionne C.A., Contreras P.C., Miller M.S., and Bhat R.V. Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system. J Comp Neurol 398 (1998) 373-392
16. Gourley S.L., Kiraly D.D., Howell J.L., Olausson P., and Taylor J.R. Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone. Biol Psychiatry 64 (2008) 884-890
17. Grigoriadis D.E. The corticotropin-releasing factor receptor: a novel target for the treatment of depression and anxiety-related disorders. Expert Opin Ther Targets 9 (2005) 651-684
18. Groenink L., Dirks A., Verdouw P.M., Schipholt M., Veening J.G., van der Gugten J., and Olivier B. HPA axis dysregulation in mice overexpressing corticotropin releasing hormone. Biol Psychiatry 51 (2002) 875-881
19. Hanstein R., Lu A., Wurst W., Holsboer F., Deussing J.M., Clement A.B., and Behl C. Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress. Neuroscience 156 (2008) 712-721
20. Hauger R.L., Risbrough V., Brauns O., and Dautzenberg F.M. Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. CNS Neurol Disord Drug Targets 5 (2006) 453-479
21. Herman J.P., Figueiredo H., Mueller N.K., Ulrich-Lai Y., Ostrander M.M., Choi D.C., and Cullinan W.E. Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol 24 (2003) 151-180
22. Holmes K.D., Babwah A.V., Dale L.B., Poulter M.O., and Ferguson S.S. Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and rab GTPases. J Neurochem 96 (2006) 934-949
23. Holsboer F. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J Psychiatr Res 33 (1999) 181-214
24. Holsboer F., and Ising M. Central CRH system in depression and anxiety-evidence from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol 583 (2008) 350-357
25. Ising M., Zimmermann U.S., Kunzel H.E., Uhr M., Foster A.C., Learned-Coughlin S.M., Holsboer F., and Grigoriadis D.E. High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response. Neuropsychopharmacology 32 (2007) 1941-1949
26. Kodama M., Russell D.S., and Duman R.S. Electroconvulsive seizures increase the expression of MAP kinase phosphatases in limbic regions of rat brain. Neuropsychopharmacology 30 (2005) 360-371
27. Korosi A., and Baram T.Z. The central corticotropin releasing factor system during development and adulthood. Eur J Pharmacol 583 (2008) 204-214
28. Korosi A., Veening J.G., Kozicz T., Henckens M., Dederen J., Groenink L., van der Gugten J., Olivier B., and Roubos E.W. Distribution and expression of CRF receptor 1 and 2 mRNAs in the CRF over-expressing mouse brain. Brain Res 1072 (2006) 46-54
29. Kovalovsky D., Refojo D., Liberman A.C., Hochbaum D., Pereda M.P., Coso O.A., Stalla G.K., Holsboer F., and Arzt E. Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways. Mol Endocrinol 16 (2002) 1638-1651
30. Li Y.W., Hill G., Wong H., Kelly N., Ward K., Pierdomenico M., Ren S., Gilligan P., Grossman S., Trainor G., Taub R., McElroy J., and Zazcek R. Receptor occupancy of nonpeptide corticotropin-releasing factor 1 antagonist DMP696: correlation with drug exposure and anxiolytic efficacy. J Pharmacol Exp Ther 305 (2003) 86-96
31. Lu A., Steiner M.A., Whittle N., Vogl A.M., Walser S.M., Ableitner M., Refojo D., Ekker M., Rubenstein J.L., Stalla G.K., Singewald N., Holsboer F., Wotjak C.T., Wurst W., and Deussing J.M. Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Mol Psychiatry (2008) in press
32. Meller E., Shen C., Nikolao T.A., Jensen C., Tsimberg Y., Chen J., and Gruen R.J. Region-specific effects of acute and repeated restraint stress on the phosphorylation of mitogen-activated protein kinases. Brain Res 979 (2003) 57-64
33. Merali Z., Kent P., Du L., Hrdina P., Palkovits M., Faludi G., Poulter M.O., Bedard T., and Anisman H. Corticotropin-releasing hormone, arginine vasopressin, gastrin-releasing peptide, and neuromedin B alterations in stress-relevant brain regions of suicides and control subjects. Biol Psychiatry 59 (2006) 594-602
34. Minichiello L., Korte M., Wolfer D., Kuhn R., Unsicker K., Cestari V., Rossi-Arnaud C., Lipp H.P., Bonhoeffer T., and Klein R. Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24 (1999) 401-414
35. Muller M.B., Zimmermann S., Sillaber I., Hagemeyer T.P., Deussing J.M., Timpl P., Kormann M.S., Droste S.K., Kuhn R., Reul J.M., Holsboer F., and Wurst W. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci 6 (2003) 1100-1107
36. Nemeroff C.B., Owens M.J., Bissette G., Andorn A.C., and Stanley M. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch Gen Psychiatry 45 (1988) 577-579
37. Orozco-Cabal L., Liu J., Pollandt S., Schmidt K., Shinnick-Gallagher P., and Gallagher J.P. Dopamine and corticotropin-releasing factor synergistically alter basolateral amygdala-to-medial prefrontal cortex synaptic transmission: functional switch after chronic cocaine administration. J Neurosci 28 (2008) 529-542
38. Ortiz J., Harris H.W., Guitart X., Terwilliger R.Z., Haycock J.W., and Nestler E.J. Extracellular signal-regulated protein kinases (ERKs) and ERK kinase (MEK) in brain: regional distribution and regulation by chronic morphine. J Neurosci 15 (1995) 1285-1297
39. Papadopoulou N., Chen J., Randeva H.S., Levine M.A., Hillhouse E.W., and Grammatopoulos D.K. Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity. Mol Endocrinol 18 (2004) 624-639
40. Punn A., Levine M.A., and Grammatopoulos D.K. Identification of signaling molecules mediating corticotropin-releasing hormone-R1alpha-mitogen-activated protein kinase (MAPK) interactions: the critical role of phosphatidylinositol 3-kinase in regulating ERK1/2 but not p38 MAPK activation. Mol Endocrinol 20 (2006) 3179-3195
41. Qi X., Lin W., Li J., Pan Y., and Wang W. The depressive-like behaviors are correlated with decreased phosphorylation of mitogen-activated protein kinases in rat brain following chronic forced swim stress. Behav Brain Res 175 (2006) 233-240
42. Refojo D., Echenique C., Muller M.B., Reul J.M., Deussing J.M., Wurst W., Sillaber I., Paez-Pereda M., Holsboer F., and Arzt E. Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas. Proc Natl Acad Sci U S A 102 (2005) 6183-6188
43. Reyes B.A., Valentino R.J., and Van Bockstaele E.J. Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neurons. Endocrinology 149 (2008) 122-130
44. Shen C.P., Tsimberg Y., Salvadore C., and Meller E. Activation of erk and JNK MAPK pathways by acute swim stress in rat brain regions. BMC Neurosci 5 (2004) 36
45. Smith G.W., Aubry J.M., Dellu F., Contarino A., Bilezikjian L.M., Gold L.H., Chen R., Marchuk Y., Hauser C., Bentley C.A., Sawchenko P.E., Koob G.F., Vale W., and Lee K.F. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 20 (1998) 1093-1102
46. Smith S.M., and Vale W.W. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci 8 (2006) 383-395
47. Stenzel-Poore M.P., Cameron V.A., Vaughan J., Sawchenko P.E., and Vale W. Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice. Endocrinology 130 (1992) 3378-3386
48. Stenzel-Poore M.P., Heinrichs S.C., Rivest S., Koob G.F., and Vale W.W. Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. J Neurosci 14 (1994) 2579-2584
49. Swanson L.W., Sawchenko P.E., Rivier J., and Vale W.W. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 36 (1983) 165-186
50. Sweatt J.D. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 76 (2001) 1-10
51. Teli T., Markovic D., Levine M.A., Hillhouse E.W., and Grammatopoulos D.K. Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization. Mol Endocrinol 19 (2005) 474-490
52. Thomas G.M., and Huganir R.L. MAPK cascade signalling and synaptic plasticity. Nat Rev Neurosci 5 (2004) 173-183
53. Timpl P., Spanagel R., Sillaber I., Kresse A., Reul J.M., Stalla G.K., Blanquet V., Steckler T., Holsboer F., and Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet 19 (1998) 162-166
54. Todorovic C., Sherrin T., Pitts M., Hippel C., Rayner M., and Spiess J. Suppression of the MEK/Erk signaling pathway reverses depression-like behaviors of CRF(2)-deficient mice. Neuropsychopharmacology (2008) Advance online publication 8 [doi: 10.1038/npp.2008.178]
55. Vale W., Spiess J., Rivier C., and Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213 (1981) 1394-1397
56. Van Pett K., Viau V., Bittencourt J.C., Chan R.K., Li H.Y., Arias C., Prins G.S., Perrin M., Vale W., and Sawchenko P.E. Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol 428 (2000) 191-212
57. Zambrowicz B.P., Imamoto A., Fiering S., Herzenberg L.A., Kerr W.G., and Soriano P. Disruption of overlapping transcripts in the Rosa beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci U S A 94 (1997) 3789-3794