Identification of signaling molecules mediating corticotropin-releasing hormone-R1α-mitogen-activated protein kinase (MAPK) interactions: The critical role of phosphatidylinositol 3-kinase in regulating ERK1/2 but not p38 MAPK activation

Molecular Endocrinology

Volumn 20, Issue 12, 2006, Pages 3179-3195

  Punn, Anu ^a   Levine, Michael A ^b   Grammatopoulos, Dimitris K ^a,c  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b LERNER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN; TRANSDUCIN; UROCORTIN;

ARTICLE; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; TRANSACTIVATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELLS, CULTURED; CORTICOTROPIN-RELEASING HORMONE; ENZYME ACTIVATION; GTP-BINDING PROTEINS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSDUCIN;

EID: 33751515103     PISSN: 08888809     EISSN: 08888809     Source Type: Journal    
DOI: 10.1210/me.2006-0255     Document Type: Article

References (42)

1. Bale TL, Vale WW 2004 CRF and CRF receptors: role in stress responsivity and other behaviours. Annu Rev Pharmacol Toxicol 44:525-557
2. Hillhouse EW, Grammatopoulos DK 2006 The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Endocr Rev 27:260-286
3. Grammatopoulos DK, Chrousos GP 2002 Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists. Trends Endocrinol Metab 10:436-444
4. Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W 1998 Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet 19:162-166
5. Chen R, Lewis KA, Perrin MH, Vale WW 1993 Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci USA 90:8967-8971
6. Kovalovsky D, Refojo D, Liberman AC, Hochbaum D, Pereda MP, Coso OA, Stalla GK, Holsboer F, Arzt E 2002 Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways. Mol Endocrinol 16:1638-1651
7. Kageyama K, Suda T 2003 Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5′-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells. Endocrinology 144:2234-2241
8. Dermitzaki E, Tsatsanis C, Gravanis A, Margioris AN 2002 Corticotropin-releasing hormone (CRH) induces Fas ligand production and apoptosis in PC12 cells via activation of p38 MAPK. J Biol Chem 277:12280-12287
9. Karteris E, Hillhouse EW, Grammatopoulos D 2004 Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility. Endocrinology 145:890-900
10. Elliott-Hunt CR, Kazlauskaite J, Wilde GJC, Grammatopoulos D, Hillhouse EW 2002 Potential signalling pathways underlying Corticotropin-releasing hormone's mediated neuroprotectionfrom excitotoxicity in rat hippocampus. J Neurochem 80:416-425
11. Brar BK, Jonassen AK, Stephanou A, Santilli G, Railson J, Knight RA, Yellon DM, Latchman DS 2000 Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway. J Biol Chem 275:8508-8514
12. Grammatopoulos DK, Randeva HS, Levine MA, Katsanou ES, Hillhouse EW 2000 Urocortin, but not corticotropin-releasing hormone (CRH), activates the mitogen-activated protein kinase signal transduction pathway in human pregnant myometrium: an effect mediated via R1α and R2β CRH receptor subtypes and stimulation of Gq-proteins. Mol Endocrinol 14:2076-2091
13. Brar BK, Chen A, Perrin MH, Vale W 2004 Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin- releasing factor (CRF) receptors 1 and 2β by the CRF/urocortin family of peptides. Endocrinology 145:1718-1729
14. Pippig S, Andexinger S, Lohse MJ 1995 Sequestration and recycling of β2-adrenergic receptors permit receptor resensitization. Mol Pharmacol 47:666-676
15. Ray E, Samanta AK 1996 Dansyl cadaverine regulates ligand induced endocytosis of interleukin-8 receptor in human polymorphonuclear neutrophils. FEBS Lett 378:235-239
16. Hertel C, Coulter SJ, Perkins JP 1985 A comparison of catecholamine-induced internalization of β-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenyl arsine oxide. J Biol Chem 260:12547-12553
17. Markovic D, Papadopoulou N, Teli T, Randeva H, Levine MA, Hillhouse EW, Grammatopoulos DK 2006 Differential responses of CRH receptor type 1 variants to PKC phosphorylation. J Pharm Exper Ther 319:1-11
18. Sato K, Sato A, Aoto M, Fukami Y 1995 c-Src phosphorylates epidermal growth factor receptor on tyrosine 845. Biochem Biophys Res Commun 215:1078-1087
19. Sorkin A, Waters C, Overholser KA, Carpenter G 1991 Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis J Biol Chem 266:8355-8362
20. Helin K, Beguinot L 1991 Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines. J Biol Chem 266:8363-8368
21. Teli T, Markovic D, Levine MA, Hillhouse EW, Grammatopoulos DK 2005 Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization. Mol Endocrinol 19:474-490
22. Liebmann C 2001 Regulation of MAP kinase activity by peptide receptor signalling pathway: paradigms of multiplicity. Cell Signal 13:777-785
23. Burgering BM, de Vries-Smits, AM, Medema RH, van Weeren PC, Tertoolen LG, Bos JL 1993 Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Mol Cell Biol 13:7248-7256
24. Shah BH, Yesilkaya A, Olivares-Reyes JA, Chen HD, Hunyady L, Catt KJ 2004 Differential pathways of angiotensin II-induced extracellularly regulated kinase 1/2 phosphorylation in specific cell types: role of heparin-binding epidermal growth factor. Mol Endocrinol 18:2035-2048
25. Garcia Z, Kumar A, Marques M, Cortes I, Carrera AC 2006 Phosphoinositide 3-kinase controls early and late events in mammalian cell division. EMBO J 25:655-656
26. Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R 1997 J Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ. Science 275:394-397
27. Hu Y, Qiao L, Wang S, Rong SB, Meuillet EJ, Berggren M, Gallegos A, Powis G, Kozikowski AP 2000 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth. J Med Chem 43:3045-3051
28. Park HJ, Kim HJ, Lee JH, Lee JY, Cho BK, Kang JS, Kang H, Yang Y, Cho DH 2005 Corticotropin-releasing hormone (CRH) downregulates interleukin-18 expression in human HaCaT keratinocytes by activation of p38 mitogen-activated protein kinase (MAPK) pathway. J Invest Dermatol 124:751-755
29. Cao J, Cetrulo CL, Theoharides TC 2006 Corticotropin-releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen-activated protein kinase pathway. Mol Pharmacol 69:998-1006
30. Lefkowitz RJ, Shenoy SK 2005 Transduction of receptor signals by b-arrestins. Science 308:512-517
31. Pierce KL, Luttrell LM, Lefkowitz RJ 2001 New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 20:1532-1539
32. Beom SR, Cheong D, Torres G, Caron MG, Kim K-M 2004 Comparative studies of molecular mechanisms of dopamine D2 and d3 receptors for the activation of extracellular signal-regulated kinase. J Biol Chem 279:28304-28314
33. Bao J, Alroy I, Waterman H, Schejter ED, Brodie C, Gruenberg J, Yarden Y 2000 Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome. J Biol Chem 275:26178-26186
34. 1 and epidermal growth factor receptors. Mol Pharmacol 68:356-364
35. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A 1999 EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884-888
36. Zhao Y, He D, Saatian B, Watkins T, Spannhake EW, Pyne NJ, Natarajan V, 2006 Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase C δ, Lyn kinase and matrix metalloproteinases. J Biol Chem, in press
37. Stirnweiss J, Valkova C, Ziesche E, Drube S, Liebmann C 2006 Muscarinic M2 rceptors mediate transactivation of EGF receptor through Fyn kinase and without matrix metalloproteases. Cell Signal 18:1338-1349
38. Shah BH, Baukal AJ, Shah FB, Catt KJ 2005 Mechanisms of extracellularly regulated kinases 1/2 activation in adrenal glomerulosa cells by lysophosphatidic acid and epidermal growth factor. Mol Endocrinol 19:2535-2548
39. Waters CM, Connell MC, Pyne S, Pyne NJ 2005 c-Src is involved in regulating signal transmission from PDGFβ receptor-GPCR complexes in mammalian cells. Cell Signal 17:263-277
40. Toker A 2000 Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol Pharmacol 57:652-658
41. Brar BK, Stephanou A, Knight R, Latchman DS 2002 Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death. J Mol Cell Cardiol 34:483-492
42. Hammarberg C, Fredholm BB, Schulte G 2004 Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3′-kinase. Biochem Pharmacol 67:129-134