2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 5, 2009, Pages 2047-2068

  Voelker, Troy ^a   Xia, Haiji ^a   Fandrick, Keith ^a   Johnson, Robert ^b   Janowsky, Aaron ^b   Cashman, John R ^a  

^a HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (AMINOETHYL) 5 (20 METHOXY 50 FLUOROPHENETHYL)TETRAHYDROFURAN; 2 AMINOETHYL 5 [3' (2''METHOXY 5'' FLUOROPHENYL) 1' PROPYL]TETRAHYDROFURAN; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; COCAINE; FLUOXETINE; NORADRENALIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TETRAHYDROFURAN DERIVATIVE; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG POTENCY; DRUG STRUCTURE; FORCED SWIMMING TEST; IC 50; ISOTOPE LABELING; LIPOPHILICITY; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; RAT; SEROTONIN RELEASE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTIDEPRESSIVE AGENTS; COCAINE; DOPAMINE; FURANS; MICE; MICE, INBRED BALB C; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SWIMMING;

MUS;

EID: 61349170780     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.023     Document Type: Article

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