5′-O-alkyl ethers of N,2-substituted adenosine derivatives: Partial agonists for the adenosine A1 and A3 receptors

Journal of Medicinal Chemistry

Volumn 44, Issue 18, 2001, Pages 2966-2975

  Van Tilburg, E W ^a   Van der Klein, P A M ^a   Von Frijtag Drabbe Kunzel J ^a   De Groote, M ^a   Stannek, C ^b   Lorenzen, A ^b   IJzerman, A P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N CYCLOPENTYL 5' O METHYLADENOSINE; 5' O ETHYL N (3 IODOBENZYL)ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DERIVATIVE; CHLORINE DERIVATIVE; CYCLIC AMP; ETHER DERIVATIVE; FORSKOLIN; GUANOSINE DERIVATIVE; N (3 IODOBENZYL) 5' O METHYLADENOSINE; PURINE DERIVATIVE; SULFUR 35; UNCLASSIFIED DRUG; 5'-O-ETHYL-N-(3-IODOBENZYL)ADENOSINE; ADENOSINE; ADENOSINE RECEPTOR; DRUG DERIVATIVE; N-(3-IODOBENZYL)-5'-O-METHYLADENOSINE;

AMINATION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONCENTRATION (PARAMETERS); DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GLYCOSYLATION; NONHUMAN; ANIMAL; BINDING COMPETITION; BIOSYNTHESIS; BRAIN CORTEX; CELL LINE; CHEMISTRY; DRUG POTENTIATION; HAMSTER; HUMAN; IN VITRO STUDY; METABOLISM; RADIOASSAY; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADENOSINE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CEREBRAL CORTEX; CRICETINAE; CYCLIC AMP; HUMANS; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035974620     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001114o     Document Type: Article

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