An enantioselective formal synthesis of (+)-(R)-α-lipoic acid by an L-proline-catalyzed aldol reaction

Synthesis

Volumn , Issue 3, 2008, Pages 0383-0386

  Zhang, Shilei ^a   Chen, Xiaobei ^b   Zhang, Jiangang ^b   Wang, Wei ^a,c   Duan, Wenhu ^a,b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Aldehyde; Aldol reaction; Ketone; Lipoic acid; Proline

Indexed keywords

ALDOL REACTION; CROSS-ALDOL REACTION;

CATALYST ACTIVITY; ENANTIOSELECTIVITY; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

2 (BENZYLOXY) 1 HYDROXYETHYL CYCLOHEXANONE; 2 (BENZYLOXY) 1 HYDROXYETHYL]OXEPAN 2 ONE; 7 (1 HYDROXY 2 IOSOETHYL)OXEPAN 2 ONE; 7 (2 HYDROXYETHYL)OXEPAN 2 ONE; BETA HYDROXY KETONE; KETONE DERIVATIVE; LACTONE; METHYL 6,8 DIHYDROXYOCTANOATE; PROLINE; THIOCTIC ACID; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CATALYSIS; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY;

EID: 39349114022     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1032022     Document Type: Article

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