Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 20, 2006, Pages 5392-5397

  Vara Prasad, J V N ^a   Boyer, Frederick E ^a   Chupak, Lou ^b   Dermyer, Michael ^a   Ding, Qizhu ^c   Gavardinas, K ^b   Hagen, Susan E ^a   Huband, Michael D ^a   Jiao, Wenhua ^b   Kaneko, Takushi ^b   Maiti, Samarendra N ^a   Melnick, Michael ^a   Romero, Karina ^b   Patterson, M ^b   Wu, Xiujuan ^c  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c NAEJA Pharmaceutical Inc   (Canada)

Author keywords

Antibacterial agents; Gram negative activity; Oxazolidinones

Indexed keywords

ANTIINFECTIVE AGENT; EPEREZOLID; INDANONE DERIVATIVE; LINEZOLID; N [[3 (4 ACETYLPHENYL) 2 OXO 5 OXAZOLIDINYL]METHYL]ACETAMIDE; OXAZOLIDINONE DERIVATIVE; PNU 82965;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; BENZOCYCLOHEPTENES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXAZOLIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

NEGIBACTERIA;

EID: 33748297496     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.064     Document Type: Article

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