Toll-like receptor 3 is necessary for dsRNA adjuvant effects

Vaccine

Volumn 27, Issue 12, 2009, Pages 1841-1847

  Salaun, Bruno ^a   Greutert, Maude ^a   Romero, Pedro ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

Author keywords

CD8 T cells; Immune response; Immunological adjuvants; Vaccination

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR 3;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADJUVANTS, IMMUNOLOGIC; ADSORPTION; ALUMINUM HYDROXIDE; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; BODY TEMPERATURE; DNA; ETHYLENE GLYCOLS; EXTRACELLULAR FLUID; HUMANS; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; ISOELECTRIC FOCUSING; MICE; SHEEP; THERMODYNAMICS; TOLL-LIKE RECEPTOR 3; VACCINES;

EID: 61349125442     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.01.044     Document Type: Article

References (36)

1. Akira S., and Takeda K. Toll-like receptor signalling. Nat Rev Immunol 4 7 (2004) 499-511
2. Iwasaki A., and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 5 10 (2004) 987-995
3. Reis e Sousa C. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin Immunol 16 1 (2004) 27-34
4. Schnare M., Barton G.M., Holt A.C., Takeda K., Akira S., and Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2 10 (2001) 947-950
5. Pulendran B., and Ahmed R. Translating innate immunity into immunological memory: implications for vaccine development. Cell 124 4 (2006) 849-863
6. Kanzler H., Barrat F.J., Hessel E.M., and Coffman R.L. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 13 5 (2007) 552-559
7. van Duin D., Medzhitov R., and Shaw A.C. Triggering TLR signaling in vaccination. Trends Immunol 27 1 (2006) 49-55
8. Chaput N., Schartz N.E., Andre F., Taieb J., Novault S., Bonnaventure P., et al. Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection. J Immunol 172 4 (2004) 2137-2146
9. Speiser D.E., Lienard D., Rufer N., Rubio-Godoy V., Rimoldi D., Lejeune F., et al. Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J Clin Invest 115 3 (2005) 739-746
10. Zhu X., Nishimura F., Sasaki K., Fujita M., Dusak J.E., Eguchi J., et al. Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med 5 (2007) 10
11. Salem M.L., Kadima A.N., Cole D.J., and Gillanders W.E. Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling: evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity. J Immunother 28 3 (2005) 220-228
12. Kabelitz D. Expression and function of Toll-like receptors in T lymphocytes. Curr Opin Immunol 19 1 (2007) 39-45
13. Liu H., Komai-Koma M., Xu D., and Liew F.Y. Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci USA 103 18 (2006) 7048-7053
14. Sutmuller R.P., den Brok M.H., Kramer M., Bennink E.J., Toonen L.W., Kullberg B.J., et al. Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest 116 2 (2006) 485-494
15. Peng G., Guo Z., Kiniwa Y., Voo K.S., Peng W., Fu T., et al. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 309 5739 (2005) 1380-1384
16. Crellin N.K., Garcia R.V., Hadisfar O., Allan S.E., Steiner T.S., and Levings M.K. Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+ CD25+ T regulatory cells. J Immunol 175 12 (2005) 8051-8059
17. Caron G., Duluc D., Fremaux I., Jeannin P., David C., Gascan H., et al. Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells. J Immunol 175 3 (2005) 1551-1557
18. Cottalorda A., Verschelde C., Marcais A., Tomkowiak M., Musette P., Uematsu S., et al. TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation. Eur J Immunol 36 7 (2006) 1684-1693
19. Komai-Koma M., Jones L., Ogg G.S., Xu D., and Liew F.Y. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci USA 101 9 (2004) 3029-3034
20. Wesch D., Beetz S., Oberg H.H., Marget M., Krengel K., and Kabelitz D. Direct costimulatory effect of tlr3 ligand poly(I:C) on human {gamma}{delta} T lymphocytes. J Immunol 176 3 (2006) 1348-1354
21. Mansson A., Adner M., and Cardell L.O. Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. Respir Res 7 (2006) 36
22. Tabiasco J., Devevre E., Rufer N., Salaun B., Cerottini J.C., Speiser D., et al. Human effector CD8+ T lymphocytes express TLR3 as a functional coreceptor. J Immunol 177 12 (2006) 8708-8713
23. Bachmann M.F., Wolint P., Schwarz K., Jager P., and Oxenius A. Functional properties and lineage relationship of CD8+ T cell subsets identified by expression of IL-7 receptor alpha and CD62L. J Immunol 175 7 (2005) 4686-4696
24. Heinz S., Haehnel V., Karaghiosoff M., Schwarzfischer L., Muller M., Krause S.W., et al. Species-specific regulation of Toll-like receptor 3 genes in men and mice. J Biol Chem 278 24 (2003) 21502-21509
25. Salem M.L., El-Naggar S.A., Kadima A., Gillanders W.E., and Cole D.J. The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu. Vaccine 24 24 (2006) 5119-5132
26. Hervas-Stubbs S., Olivier A., Boisgerault F., Thieblemont N., and Leclerc C. TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help. Blood 109 12 (2007) 5318-5326
27. Schulz O., Diebold S.S., Chen M., Naslund T.I., Nolte M.A., Alexopoulou L., et al. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433 7028 (2005) 887-892
28. Durand V., Wong S.Y., Tough D.F., and Le Bon A. Shaping of adaptive immune responses to soluble proteins by TLR agonists: a role for IFN-alpha/beta. Immunol Cell Biol 82 6 (2004) 596-602
29. Durand V., Wong S.Y., Tough D.F., and Le Bon A. IFN-alpha/beta-dependent cross-priming induced by specific toll-like receptor agonists. Vaccine 24 Suppl. 2 (2006) S2-22-3
30. Gitlin L., Barchet W., Gilfillan S., Cella M., Beutler B., Flavell R.A., et al. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci USA 103 22 (2006) 8459-8464
31. Kumar H., Koyama S., Ishii K.J., Kawai T., and Akira S. Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses. J Immunol 180 2 (2008) 683-687
32. Hoebe K., Janssen E.M., Kim S.O., Alexopoulou L., Flavell R.A., Han J., et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol 4 12 (2003) 1223-1229
33. Qiu F., and Cui Z. CD4+ T helper cell response is required for memory in CD8+ T lymphocytes induced by a poly(I:C)-adjuvanted MHC I-restricted peptide epitope. J Immunother 30 2 (1997 2007) 180-189
34. Gelman A.E., Zhang J., Choi Y., and Turka L.A. Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol 172 10 (2004) 6065-6073
35. Bahl K., Kim S.K., Calcagno C., Ghersi D., Puzone R., Celada F., et al. IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections. J Immunol 176 7 (2006) 4284-4295
36. McNally J.M., Zarozinski C.C., Lin M.Y., Brehm M.A., Chen H.D., and Welsh R.M. Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses. J Virol 75 13 (2001) 5965-5976