Studies on bioadhesive PLGA nanoparticles: A promising gene delivery system for efficient gene therapy to lung cancer

International Journal of Pharmaceutics

Volumn 370, Issue 1-2, 2009, Pages 187-195

  Zou, Weiwei ^a   Liu, Chunxi ^a   Chen, Zhijin ^a   Zhang, Na ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Bioadhesive nanoparticles; Carbopol (CP); Gene delivery; Lung cancer; PLGA

Indexed keywords

CARBOMER; CARBOPOL 940; LIPOFECTAMINE; NAKED DNA; POLOXAMER; POLYGLACTIN;

ARTICLE; CANCER GENE THERAPY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA BINDING; DRUG CYTOTOXICITY; DRUG FORMULATION; DRUG STABILITY; ENZYMATIC DEGRADATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MORPHOLOGICAL TRAIT; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE CHARGE;

ACRYLIC RESINS; ADHESIVENESS; CELL LINE, TUMOR; CELL SURVIVAL; DNA; DRUG CARRIERS; GENE TRANSFER TECHNIQUES; HUMANS; LACTIC ACID; LIPIDS; LUNG NEOPLASMS; NANOPARTICLES; PARTICLE SIZE; POLOXAMER; POLYGLYCOLIC ACID; SURFACE PROPERTIES; TRANSFECTION;

EID: 61349092292     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.11.016     Document Type: Article

References (39)

1. Agarwal A., Unfer R.C., and Mallapragada S.K. Dual-role self-assembling nanoplexes for efficient gene transfection and sustained gene delivery. Biomaterials 29 (2008) 607-617
2. Alpar H.O., Somavarapu S., Atuah K.N., and Bramwell V.W. Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery. Adv. Drug Deliv. Rev. 57 (2005) 411-430
3. Basarkar A., Devineni D., Palaniappan R., and Singh J. Preparation, characterization, cytotoxicity and transfection efficiency of poly(dl-lactide-co-glycolide) and poly(dl-lactic acid) cationic nanoparticles for controlled delivery of plasmid DNA. Int. J. Pharm. 343 (2007) 247-254
4. Belenkov A.I., Alakhov V.Y., Kabanov A.V., Vinogradov S.V., Panasci L.C., Monia B.P., and Chow T.Y. Polyethyleneimine grafted with Pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo. Gene Ther. 11 (2004) 1665-1672
5. Cui F., Qian F., and Yin C. Preparation and characterization of mucoadhesive polymer-coated nanoparticles. Int. J. Pharm. 316 (2006) 154-161
6. Dang J.M., and Leong K.W. Natural polymers for gene delivery and tissue engineering. Adv. Drug Deliv. Rev. 58 (2006) 487-499
7. de la Fuente M., Seijo B., and Alonso M.J. Bioadhesive hyaluronan-chitosan nanoparticles can transport genes across the ocular mucosa and transfect ocular tissue. Gene Ther. 15 (2008) 668-676
8. Fenske D.B., MacLachlan I., and Cullis P.R. Long-circulating vectors for the systemic delivery of genes. Curr. Opin. Mol. Ther. 3 (2001) 153-158
9. Fessi H., Puisieux F., Devissaguet J.P., Ammoury N., and Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int. J. Pharm. 55 (1989) R1-R4
10. Grabovac V., Guggi D., and Bernkop-Schnürch A. Comparison of the mucoadhesive properties of various polymers. Adv. Drug Deliv. Rev. 57 (2005) 1713-1723
11. Haas J., and Lehr C.M. Developments in the area of bioadhesive drug delivery systems. Expert Opin. Biol. Ther. 2 (2002) 287-298
12. Jeon E., Kim H.D., and Kim J.S. Pluronic-grafted poly-(l)-lysine as a new synthetic gene carrier. J. Biomed. Mater. Res. A 66 (2003) 854-859
13. Kim I.S., Lee S.K., Park Y.M., Lee Y.B., Shin S.C., Lee K.C., and Oh I.J. Physicochemical characterization of poly(l-lactic acid) and poly(d,l-lactide-co-glycolide) nanoparticles with polyethylenimine as gene delivery carrier. Int. J. Pharm. 298 (2005) 255-262
14. Kockisch S., Rees G.D., Young S.A., Tsibouklis J., and Smart J.D. A direct-staining method to evaluate the mucoadhesion of polymers from aqueous dispersion. J. Control. Rel. 77 (2001) 1-6
15. Lemieux P., Guérin N., Paradis G., Proulx R., Chistyakova L., Kabanov A., and Alakhov V. A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle. Gene Ther. 7 (2000) 986-991
16. Li S.D., and Huang L. Non-viral is superior to viral gene delivery. J. Control. Rel. 123 (2007) 181-183
17. Mahato R.I., Takakura Y., and Hashida M. Nonviral vectors for in vivo gene delivery: physicochemical and pharmacokinetic considerations. Crit. Rev. Ther. Drug Carrier Syst. 14 (1997) 133-172
18. Mundargi R.C., Babu V.R., Rangaswamy V., Patel P., and Aminabhavi T.M. Nano/micro technologies for delivering macromolecular therapeutics using poly(d,l-lactide-co-glycolide) and its derivatives. J. Control. Rel. 125 (2008) 193-209
19. Munier S., Messai I., Delair T., Verrier B., and Ataman-Onal Y. Cationic PLA nanoparticles for DNA delivery: comparison of three surface polycations for DNA binding, protection and transfection properties. Colloids Surf. B. Biointerfaces 43 (2005) 163-173
20. Ogris M., and Wagner E. Targeting tumors with non-viral gene delivery systems. Drug Discov. Today 7 (2002) 479-485
21. Oster C.G., and Kissel T. Comparative study of DNA encapsulation into PLGA microparticles using modified double emulsion methods and spray drying techniques. J. Microencapsul. 22 (2005) 235-244
22. Panyam J., and Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 55 (2003) 329-347
23. Panyam J., Zhou W.Z., Prabha S., Sahoo S.K., and Labhasetwar V. Rapid endo-lysosomal escape of poly(dl-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery. FASEB J. 16 (2002) 1217-1226
24. Park M.R., Han K.O., Han I.K., Cho M.H., Nah J.W., Choi Y.J., and Cho C.S. Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers. J. Control. Rel. 105 (2005) 367-380
25. Prabha S., Zhou W.Z., Panyam J., and Labhasetwar V. Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles. Int. J. Pharm. 244 (2002) 105-115
26. Prego C., García M., Torres D., and Alonso M.J. Transmucosal macromolecular drug delivery. J. Control. Rel. 101 (2005) 151-162
27. Ravi Kumar M.N., Bakowsky U., and Lehr C.M. Preparation and characterization of cationic PLGA nanospheres as DNA carriers. Biomaterials 25 (2004) 1771-1777
28. Riera M., Chillon M., Aran J.M., Cruzado J.M., Torras J., Grinyó J.M., and Fillat C. Intramuscular SP1017-formulated DNA electrotransfer enhances transgene expression and distributes hHGF to different rat tissues. J. Gene Med. 6 (2004) 111-118
29. Sasaki H., Endo K., Takada M., Kawahara M., Tanaka H., Kitahara N., Matsumura A., Iuchi K., Kawaguchi T., Okuda K., Kawano O., Yukiue H., Yokoyama T., Yano M., and Fujii Y. EGFR polymorphism of the kinase domain in Japanese lung cancer. J. Surg. Res. 148 (2008) 260-263
30. Sriadibhatla S., Yang Z., Gebhart C., Alakhov V.Y., and Kabanov A. Transcriptional activation of gene expression by Pluronic block copolymers in stably and transiently transfected cells. Mol. Ther. 13 (2006) 804-813
31. Singh M., Briones M., Ott G., and O'Hagan D. Cationic microparticles: a potent delivery system for DNA vaccines. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 811-816
32. Singh M., Fang J.H., Kazzaz J., Ugozzoli M., Chesko J., Malyala P., Dhaliwal R., Wei R., Hora M., and O'Hagan D. A modified process for preparing cationic polylactide-co-glycolide microparticles with adsorbed DNA. Int. J. Pharm. 327 (2006) 1-5
33. Swami A., Aggarwal A., Pathak A., Patnaik S., Kumar P., Singh Y., and Gupta K.C. Imidazolyl-PEI modified nanoparticles for enhanced gene delivery. Int. J. Pharm. 335 (2007) 180-192
34. Taetz S., Nafee N., Beisner J., Piotrowska K., Baldes C., Mürdter T.E., Huwer H., Schneider M., Schaefer U.F., Klotz U., and Lehr C.M. The influence of chitosan content in cationic chitosan/PLGA nanoparticles on the delivery efficiency of antisense 2′-O-methyl-RNA directed against telomerase in lung cancer cells. Eur. J. Pharm. (2008) (Epub ahead of print)
35. Tinsley-Bown A.M., Fretwell R., Dowsett A.B., Davis S.L., and Farrar G.H. Formulation of poly(d,l-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery. J. Control. Rel. 66 (2000) 229-241
36. Vandervoort J., and Ludwig A. Biocompatible stabilizers in the preparation of PLGA nanoparticles: a factorial design study. Int. J. Pharm. 238 (2002) 77-92
37. Wu J.Q., Zhao W.H., Yan L., Bei Z., and Yin K.S. Adeno-associated virus mediated gene transfer into lung cancer cells promoting CD40 ligand-based immunotherapy. Virology 368 (2007) 309-316
38. Ye J.S., Zhang N., Ma C.H., and Huang G.H. SYBR Green I-fluorometry determination of content and entrapment efficiency of protamine-pDNA complex loaded solid lipid nanoparticles. Chin. J. Pharm. Anal. 27 (2007) 1769-1772
39. Zhang S., Zhao B., Jiang H., Wang B., and Ma B. Cationic lipids and polymers mediated vectors for delivery of siRNA. J. Control. Rel. 123 (2007) 1-10