β2 Adrenergic receptor on T lymphocytes and its clinical implications

Progress in Natural Science

Volumn 19, Issue 1, 2009, Pages 17-23

  Fan, Xuelai ^a   Wang, Yuedan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Autoimmune; Neuroimmunology; T cell; 2 adrenergic receptor

Indexed keywords

CELL PROLIFERATION; CROSSTALK;

ADRENERGIC RECEPTORS; AUTOIMMUNE; CROSS TALKS; HEALTHY INDIVIDUALS; HOMOEOSTASIS; INTRACELLULAR PATHWAYS; NEUROIMMUNOLOGY; REGULATORY MECHANISM; T LYMPHOCYTES; Β2-ADRENERGIC RECEPTOR;

T-CELLS;

EID: 60949109082     PISSN: 10020071     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnsc.2008.10.001     Document Type: Review

References (65)

1. Steinman L. Elaborate interactions between the immune and nervous systems. Nat Immunol 2004;5:575-81.
2. Kohm AP, Sanders VM. Norepinephrine: a messenger from the brain to the immune system. Immunol Today 2000, 21(11):539-42.
3. Su L, Lineberry N, Huh Y, et al. A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes. J Immunol 2006;177(11):7559-66.
4. Guimond J, Mamarbachi AM, Allen BG, et al. Role of specific protein kinase C isoforms in modulation of betal- and beta2-adrenergic receptors. Cell Signal 2005;17(1):49-58.
5. Allen JA, Yu JZ, Donati RJ, et al. Beta-adrenergic receptor stimulation promotes G alpha's internalization through lipid rafts: a study in living cells. Mol Pharmacol 2005;67(5): 1493-504.
6. Bylund DB, Bond RA, Clarke DE, et al. In: The IUPHAR compendium of receptor characterization and classification. London: IUPHAR; 1998. p. 58-74.
7. [3H] alprenolol binding. J Clin Invest 1976;57:149-55.
8. Cao L, Hudson CA, Lawrence DA. Acute cold/restraint stress inhibits host resistance to Listeria monocytogenes via betal-adrenergic receptors. Brain Behav Immun 2003;17(2):121-33.
9. Lamas O, Martinez JA, Marti A. Effects of a beta3-adrenergic agonist on the immune response in diet-induced (cafeteria) obese animals. J Physiol Biochem 2003;59(3): 183-91.
10. Wahle M, Stachetzki U, Krause A, et al. Regulation of beta2- adrenergic receptors on CD4 and CD8 positive lymphocytes by cytokines in vitro. Cytokine 2001;16(6):205-9.
11. Shephard RJ. Adhesion molecules, catecholamines and leucocyte redistribution during and following exercise. Sports Med 2003;33(4):261-84.
12. + T cells exposed to norepinephrine. Brain Behav Immun 2000;14(4):239-55.
13. Sanders VM, Baker RA, Ramer-Quinn DS, et al. Differential expression of the beta-2-adrenergic receptor by Thl and Th2 clones: implications for cytokine production and B cell help. J Immunol 1997;158:4200-10.
14. Heijink IH, Vellenga E, Borger P, et al. Polarized Thl and Th2 cells are less responsive to negative feedback by receptors coupled to the AC/cAMP system compared to freshly isolated T cells, Br J Pharmacol 2003;138:1441-50.
15. Loza MJ, Foster S, Peters SP, et al. Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells. Blood 2006;107(5):2052-60.
16. Loza MJ, Foster S, Stephen P, et al. Interactive effects of steroids and P-agonists on accumulation of type 2 T cells. J Allergy Clin Immunol 2008;121(3):750-5.
17. Sanders VM. Epigenetic regulation of Thl and Th2 cell development. Brain Behav Immun 2006;20(4):317-24.
18. Bruck H, Leineweber K, Beilfuss A, et al. Genotype-dependent time course of lymphocyte beta 2-adrenergic receptor down-regulation. Clin Pharmacol Ther 2003;74(3):255-63.
19. Radojcic T, Baird S, Darko D, et al. Changes in P-adrenergic receptor distribution on immunocytes during differentiation: an analysis of T cells and macrophages. J Neurosci Res 1991 ;30: 328-35.
20. Cazaux CA, Sterin-Borda L, Gorelik G, et al. Down-regulation of beta-adrenergic receptors induced by mitogen activation of intracellular signaling events in lymphocytes. FEBS Lett 1995;364(2):120-4.
21. Edgar VA, Silberman DM, Cremaschi GA, et al. Altered lymphocyte catecholamine reactivity in mice subjected to chronic mild stress. Biochem Pharmacol 2003;65:15-23.
22. Klecha AJ, Barreiro-Arcos ML, Genaro AM, et al. Different mitogen-mediated beta-adrenergic receptor modulation in murine T lymphocytes depending on the thyroid status. Neuroimmunomodulation 2005;12(2):92-9.
23. Giorelli M, Livrea P, Trojano M. Post-receptorial mechanisms underlie functional disregulation of beta2-adrenergic receptors in lymphocytes from Multiple Sclerosis patients. J Neuroimmunol 2004;155:143-9.
24. Madden KS, Felten DL. Beta-adrenoceptor blockade alters thymocyte differentiation in aged mice. Cell Mol Biol (Noisy-le-grand) 2001;47(1):189-96.
25. Swanson MA, Lee WT, Sanders VM. IFN-gamma production by Thl cells generated from naive CD4+ T cells exposed to norepinephrine. J Immunol 2001;166(1):232-40.
26. Loza MJ, Peters SP, Foster S, et al. p-Agonist enhances type 2 T-cell survival and accumulation. J Allergy Clin Immunol 2007;119(1): 235-44.
27. Huang MT, Yang YH, Lin YT, et al. Beta2-agonist exerts differential effects on the development of cord blood T cells but not on peripheral blood T cells. Pediatr Allergy Immunol 2001;12(1):17-20.
28. Lamhamedi-Cherradi SE, Martin RE, Ito T, et al. Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12. J Immunol 2008;180(9):6000-9.
29. Osorio I, Shnyra A, SantaCruz K, et al. Rasmussen's encephalitis: Interleukin-10-dependent Tc2 cell polarization may explain its pathophysiology and clinical course. Epilepsy Behav 2007;10:206-11.
30. Ramer-Quinn DS, Swanson MA, Lee WT, et al. Cytokine production by naive and primary effector CD4+ T cells exposed to norepinephrine. Brain Behav Immun 2000;14(4):239-55.
31. Zheng WP, Zhao Q, Zhao X, et al. Up-regulation of Hlx in immature Th cells induces IFNgamma expression. J Immunol 2004;172:114-22.
32. Makar KW, Wilson CB. DNA methylation is a nonredundant repressor of the Th2 eVector program. J Immunol 2004;173: 4402-6.
33. Watanabe S, Yssel H, Harada Y, et al. Effects of prostaglandin E2 on Th0-type human T cell clones: modulation of functions of nuclear proteins involved in cytokine production. Int Immunol 1994;6(4):523-32.
34. Snijdewint FG, Kalinski P, Wierenga EA, et al. Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J Immunol 1993;150(12):5321-9.
35. Betz M, Fox BS. Prostaglandin E2 inhibits production of Thl lymphokines but not of Th2 lymphokines. J Immunol 1991;146(1):108-13.
36. Ramer-Quinn DS, Baker RA, Sanders VM. Activated T helper 1 and T helper 2 cells differentially express the beta-2-adrenergic receptor: a mechanism for selective modulation of T helper 1 cell cytokine production. J Immunol 1997;159(10):4857-67.
37. Borger P, Kauffman HF, Postma DS, et al. Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway. Blood 1996;87(2):691-8.
38. Kohm AP, Sanders VM. Norepinephrine and beta2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo. Pharmacol Rev 2001;53:487-525.
39. Wahle M, Neumann RP, Moritz F, et al. Beta2-adrenergic receptors mediate the differential effects of catecholamines on cytokine production of PBMC. J Interferon Cytokine Res 2005;25(7):384-94.
40. Salicru AN, Sams CF, Marshall GD. Cooperative effects of corticosteroids and catecholamines upon immune deviation of the type-1/type-2 cytokine balance in favor of type-2 expression in human peripheral blood mononuclear cells. Brain Behav Immun 2007;21(7):913-20.
41. Maestroni GJ. Short exposure of maturing, bone marrow-derived dendritic cells to norepinephrine: impact on kinetics of cytokine production and Th development. J Neuroimmunol 2002; 129(1-2): 106-14.
42. Kasprowicz DJ, Kohm AP, Berton MT, et al. Stimulation of the B cell receptor, CD86 (B7-2), and the beta 2-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell. J Immunol 2000;165(2):680-90.
43. Kasprowicz DJ, Kohm AP, Berton MT, et al. Selective regulation of mature IgGl transcription by CD86 and beta 2-adrenergic receptor stimulation. J Immunol 2003;170(10):5143-51.
44. Kohm AP, Mozaffarian A, Sanders VM. B cell receptor- and beta 2-adrenergic receptor-induced regulation of B7-2 (CD86) expression in B cells. J Immunol 2002;168(12):6314-22.
45. Pongratz G, McAlees JW, Conrad DH, et al. The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK-and CD23-dependent manner. J Immunol 2006;177(5):2926-38.
46. Huang ST, Chen GY, Wu CH, et al. Effect of disease activity and position on autonomic nervous modulation in patients with systemic lupus erythematosus. Clin Rheumatol 2008;27(3):295-300.
47. Axelrod S, Bielory L. Beta2-agonists and paresthesias in multiple sclerosis. Ann Allergy Asthma Immunol 2007;98(1):100.
48. Gold SM, Mohr DC, Huitinga I, et al. The role of stress-response systems for the pathogenesis and progression of MS. Trends Immunol 2005;26(12):644-52.
49. Wahle M, Krause A, Pierer M, et al. Immunopathogenesis of rheumatic diseases in the context of neuroendocrine interactions. Ann NY Acad Sci 2002;966:355-64.
50. Jazdzewski K, Bednarczuk T, Stepnowska M, et al. Beta-2-adrenergic receptor gene polymorphism confers susceptibility to Graves disease. Int J Mol Med 2007;19(1):181-6.
51. Frieri M. Neuroimmunology and inflammation implications for therapy of allergic and autoimmune diseases. Ann Allergy Asthma Immunol 2003;90(6 Suppl. 3):34-40.
52. Schouwenberg BJ, Veldman BA, Spiering W, et al. The Argl6Gly variant of the beta2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus. Pharmacogenet Genomics 2008;18(4):369-72.
53. Gage JR, Fonarow G, Hamilton M, et al. Beta blocker and angiotensin-converting enzyme inhibitor therapy is associated with decreased Thl/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure. Neuroimmunomodulation 2004;11(3):173-80.
54. Bailey MT, Karaszewski JW, Lubach GR, et al. In vivo adaptation of attenuated Salmonella typhimurium results in increased growth upon exposure to norepinephrine. Physiol Behav 1999;67(3):359-64.
55. Price P, Keane NM, Lee S, et al. A T2 cytokine environment may not limit Tl responses in human immunodeficiency virus patients with a favourable response to antiretroviral therapy. Immunology 2006;119(1):74-82.
56. Parrillo JE. Septic shock-vasopressin, norepinephrine, and urgency. N Engl J Med 2008;358(9):954-6.
57. Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 2008;358(9):877-87.
58. Calcagni E, Elenkov I. Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Ann NY Acad Sci 2006;1069:62-76.
59. Wahle M, Hanefeld G, Brunn S, et al. Failure of catecholamines to shift T-cell cytokine responses toward a Th2 profile in patients with rheumatoid arthritis. Arthritis Res Ther 2006;8(5):R138.
60. Xu BY, Arlehag L, Rantapaa-Dahlquist SB, et al. Beta2 Adrenoceptor gene single nucleotide polymorphisms are associated with rheumatoid arthritis in northern Sweden. Ann Rheum Dis 2005;64(5):773-6.
61. Hamada D, Takata Y, Osabe D, et al. Association between single- nucleotide polymorphisms in the SEC8L1 gene, which encodes a subunit of the exocyst complex, and rheumatoid arthritis in a Japanese population. Arthritis Rheum 2005;52(5):1371-80.
62. Eyre S, Bowes J, Potter C, et al. Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? Arthritis Res Ther 2006;8(4):R117.
63. Lubahn CL, Schaller JA, Bellinger DL, et al. The importance of timing of adrenergic drug delivery in relation to the induction and onset of adjuvant-induced arthritis. Brain Behav Immun 2004; 18(6): 563-71.
64. Harle P, Mobius D, Carr D, et al. An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis. Arthritis Rheum 2005;52(4): 1305-13.
65. Nance DM, Sanders VM. Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav Immun 2007;21(6):736-45.