Rasmussen's encephalitis: Interleukin-10-dependent Tc2 cell polarization may explain its pathophysiology and clinical course

Epilepsy and Behavior

Volumn 10, Issue 1, 2007, Pages 206-211

  Osorio, Ivan ^a   Shnyra, Alex ^b   SantaCruz, Karen ^c   Brewington, Ryan ^b   Morrison, David ^b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Anti inflammatory; Cell polarization; Cytokines; Messenger RNA; Pro inflammatory; Rasmussen's encephalitis; T cells

Indexed keywords

CD14 ANTIGEN; CD3 ANTIGEN; CD8 ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; PREDNISONE; SCAVENGER RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BRAIN BIOPSY; CASE REPORT; CD8+ T LYMPHOCYTE; CYTOLYSIS; DETERIORATION; DISEASE COURSE; DRUG MEGADOSE; EPILEPTIC STATE; EPILEPTOGENESIS; FRONTAL LOBE; HEMISPHERECTOMY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOPATHOGENESIS; INTRACTABLE EPILEPSY; LYMPHOCYTIC INFILTRATION; MALE; PATHOPHYSIOLOGY; PLASMAPHERESIS; PROTEIN EXPRESSION; RASMUSSEN SYNDROME; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TEMPORAL LOBE;

ANTIGENS, CD14; ANTIGENS, CD3; CHILD; ENCEPHALITIS; HUMANS; INTERLEUKIN-10; MALE; T-LYMPHOCYTES, CYTOTOXIC;

EID: 33846365624     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2006.09.006     Document Type: Article

References (37)

1. Krauss G.L., Campbell M.L., Roche K.W., Huganir R.L., and Niedermeyer E. Chronic steroid-responsive encephalitis without antibodies to glutamate receptor GluR3. Neurology 46 (1996) 247-249
2. Rasmussen T., Olszewski J., and Lloyd-Smith D. Focal seizures due to chronic localized encephalitis. Neurology 8 (1958) 435-445
3. Rasmussen T., and Andermann F. Update on the syndrome of "chronic encephalitis" and epilepsy. Cleve Clin J Med 56 Suppl. 2 (1989) S181-S184
4. Robitaille Y. Neuropathologic aspects of chronic encephalitis. In: Andermann F. (Ed). Chronic encephalitis and epilepsy: Rasmussen's syndrome (1991), Butterworth-Heinemann, Boston 79-86
5. Farrell M.A., Droogan O., Secor D.L., Poukens V., Quinn B., and Vinters H.V. Chronic encephalitis associated with epilepsy: immunohistochemical and ultrastructural studies. Acta Neuropathol 89 (1995) 313-321
6. Li Y., Uccelli A., Laxer K.D., et al. Local-clonal expansion of infiltrating T-lymphocytes in chronic encephalitis of Rasmussen. J Immunol 158 (1997) 1428-1437
7. Rogers S.W., Andrews P.I., Gahring L.C., et al. Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis. Science 265 (1994) 648-651
8. Hopkins S.J., and Rothwell N.J. Cytokines and the nervous system: I: expression and recognition. Trends Neurosci 18 (1995) 83-88
9. Rothwell N.J., and Hopkins S.J. Cytokines and the nervous system II. Actions and mechanisms of actions. Trends Neurosci 18 (1995) 130
10. Benveniste E.N. Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am J Physiol 263 (1992) C1-C16
11. Shnyra A.A., Brewington R., Alipio A., Amura C., and Morrison D.C. Reprogramming of LPS-primed macrophages is controlled by a counterbalanced production of IL-10 and IL-12. J Immunol 160 (1998) 3729-3736
12. Bien C.G., Bauer J., Deckwerth T.L., et al. Destruction of neurons by cytotoxic T cells: a new pathogenetic mechanism in Rasmussen's encephalitis. Ann Neurol 51 (2002) 311-318
13. Schluter D., Kaefer N., Hof H., Wiestler O.D., and Deckert-Schluter M. Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain. Am J Pathol 150 (1997) 1021-1035
14. Groux H., Bigler M., de Vries J.E., and Roncarolo M.G. Inhibitory and stimulatory effects of IL-10 on human CD8+ T-cells. J Immunol 160 (1998) 3188-3193
15. Groux H., Cottrez F., Rouleau M., et al. A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells. J Immunol 162 (1999) 1723-1729
16. Erard F., Garcia-Sanz J.A., Moriggl R., and Wild M.T. Presence or absence of TGF-B determines IL-4-induced generation of type 2 CD8 T-cells subsets. J Immunol 162 (1999) 209-214
17. Blazar B.R., Taylor P.A., Panoskaltsis-Mortari A., et al. Interleukin-10 dose-dependent regulation of CD4+ and CD8+ T-cell mediated graft-versus-host disease. Transplantation 66 (1998) 1220-1229
18. Balasa B., Davies J.D., Lee J., Good A., Yeung B.T., and Sarvetnick N. IL-10 impacts auto-immune diabetes via a CD8+ T-cell pathway circumventing the requirement for CD4+ and B-lymphocytes. J Immunol 161 (1998) 4420-4427
19. Moore K.W., O'Garra A., deWaal Malefyt R., Vieira P., and Mosmann T.R. Interleukin-10. Annu Rev Immunol 11 (1993) 165-190
20. Taga K., and Tosato G. IL-10 inhibits human T-cell proliferation and IL-2 production. J Immunol 148 (1992) 1143-1148
21. Deckert-Schluter M., Buck C., Weiner D., et al. Interleukin-10 downregulated the intracerebral immune response in chronic Toxoplasma encephalitis. J Neuroimmunol 76 (1997) 167-176
22. Williams K., Dooley N., Ulvestad E., Becher B., and Antel J.P. IL-10 production by adult human derived microglial cells. Neurochem Int 29 (1996) 55-64
23. Brodie C. Differential effect of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes. FEBS Lett 394 (1996) 117-120
24. Minghetti L., Polazzi E., Nicolini A., and Levi G. Opposite regulation of prostaglandin E2 synthesis by transforming growth factor-beta 1 and interleukin-10 in activated microglial cultures. J Neuroimmunol 82 (1998) 31-39
25. Koedel U., Bernatowicz A., Frei K., Fontana A., and Pfister H.W. Systemically (but not intrathecally) administered IL-10 attenuates pathophysiologic alterations in experimental pneumococcal meningitis. J Immunol 157 (1996) 5185-5191
26. Bell M.D., Lopez-Gonzalez R., Lawson L., Highes D., Fraser I., Gordon S., et al. Upregulation of the macrophage scavenger receptor in response to different types of injury in the CNS. J Neurocytol 23 (1994) 605-613
27. Grewal R.P., Yoshida T., Finch C.E., and Morgan T.E. Scavenger receptor mRNAs in rat brain microglia are induced by kainic acid and by cytokines. NeuroReport 8 (1997) 1077-1081
28. Cerwenka A., Carter L.L., Reome J.B., Swain S.L., and Dutton R.W. In-vivo persistence of CD8 polarized T-cell subset producing type 1 or type 2 cytokines. J Immunol 161 (1998) 97-105
29. Kelso A., and Groves P. A single peripheral T-cell can give rise to progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions. Proc Natl Acad Sci USA 94 (1997) 8070-8075
30. Slifka M.K., Rodriguez F., and Whitten J.L. Rapid on/off cycling of cytokine production by virus-specific CD8+ T-cells. Nature 401 (1999) 76-79
31. Husemann J., Loike J.D., Anankov R., Febbraio M., and Silverstein S.C. Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system. Glia 40 (2002) 195-205
32. Pearson A.M. Scavenger receptors in innate immunity. Curr Opin Immunol 8 (1996) 20-28
33. Platt N., and Gordon S. Is the class A macrophage scavenger receptor (SR-A) multifunctional? The mouse's tale. J Clin Invest 108 (2001) 649-654
34. De Bock F., Dornand J., and Rondouin G. Release of TNF-alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. NeuroReport 7 (1996) 1125-1129
35. Lehtimaki K.A., Peltola J., Koskikallio E., Keranen T., and Honkaniemi J. Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Brain Res Mol Brain Res 110 (2003) 253-260
36. Rossell D.R., Nacher J., Akama K.T., and McEwen B.S. Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation. Neuroscience 122 (2003) 329-348
37. Jankowski J.L., and Patterson P.H. The role of cytokines and growth factors in seizures and their sequelae. Prog Neurobiol 63 (2001) 125-149