Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways

European Journal of Pharmacology

Volumn 606, Issue 1-3, 2009, Pages 50-60

  Michal, Pavel ^a   Rudajev, Vladimír ^a   El Fakahany, Esam E ^b   Doležal, Vladimír ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Agonist binding; cAMP; Cholesterol; G proteins coupling; Inositolphosphate; Muscarinic receptor

Indexed keywords

CARBACHOL; CHOLESTEROL; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; METHYLSCOPOLAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHO CELL; CONTROLLED STUDY; MEMBRANE; MEMBRANE PERMEABILITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR BINDING;

ACETYLCHOLINE; ANIMALS; BETA-CYCLODEXTRINS; CARBACHOL; CELL MEMBRANE; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; GTP-BINDING PROTEINS; HUMANS; MUSCARINIC ANTAGONISTS; N-METHYLSCOPOLAMINE; RECEPTOR, MUSCARINIC M2; SECOND MESSENGER SYSTEMS;

EID: 60949102955     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.01.028     Document Type: Article

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