A novel germline mutation in Big Blue® mice

Environmental and Molecular Mutagenesis

Volumn 50, Issue 2, 2009, Pages 114-120

  Crabbe, Rory A ^a   Prtenjaca, Anita ^a   Tarnowski, Heather E ^a   Hill, Kathleen A ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Bi directional amplification of specific alleles (Bi PASA); lacl; Multiple mutations; Mutation detection assay; Spontaneous mutation; Transgenic mouse

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; GENOMIC DNA; BACTERIAL PROTEIN; ESCHERICHIA COLI PROTEIN; LACI PROTEIN, BACTERIA; REPRESSOR PROTEIN;

ALLELE; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTIFACT; GENE AMPLIFICATION; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENOME ANALYSIS; GERM LINE; MALE; MISSENSE MUTATION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; SPONTANEOUS MUTATION; ANIMAL; ANTIBODY SPECIFICITY; BACTERIOPHAGE LAMBDA; GENETICS; LACTOSE OPERON; MUTAGEN TESTING; MUTATION; TRANSGENE; TRANSGENIC MOUSE;

MURINAE; MUS; MUS MUSCULUS;

ANIMALS; BACTERIAL PROTEINS; BACTERIOPHAGE LAMBDA; ESCHERICHIA COLI PROTEINS; GERM-LINE MUTATION; LAC OPERON; MALE; MICE; MICE, TRANSGENIC; MUTAGENICITY TESTS; ORGAN SPECIFICITY; REPRESSOR PROTEINS; TRANSGENES;

EID: 60849134316     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20442     Document Type: Article

References (36)

1. Andrew SE, Xu XS, Baross-Francis A, Narayanan L, Milhausen K, Liskay RM, Jirik FR, Glazer PM. 2000. Mutagen in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis 21:1291-1295.
2. Barnett LB, Tyl RW, Shane BS, Shelby MD, Lewis SE. 2002. Transmission of mutations in the lacI transgene to the offspring of ENU-treated Big Blue® male mice. Environ Mol Mutagen 40:251-257.
3. Buettner VL, Hill KA, Nishino H, Schaid DJ, Frisk CS, Sommer SS. 1996a. Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53/ Big Blue® double transgenic mice. Oncogene 13:2407-2413.
4. Buettner VL, Nishino H, Sommer SS. 1996b. Large deletion detected with the Big Blue® transgenic mouse mutagenesis assay. Mutat Res 361:187-189.
5. Buettner VL, Nishino H, Haavik J, Knoll A, Hill K, Sommer SS. 1997. Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: A test of the 'guardian of the genome' hypothesis in the Big Blue® transgenic mouse mutation detection system. Mutat Res 379:13-20.
6. Buettner VL, Hill KA, Halangoda A, Sommer SS. 1999. Tandem-base mutations occur in mouse liver and adipose tissue preferentially as G:C to T:A transversions and accumulate with age. Environ Mol Mutagen 33:320-324.
7. Buettner VL, Hill KA, Scaringe WA, Sommer SS. 2000. Evidence that proximal multiple mutations in Big Blue® transgenic mice are dependent events. Mutat Res 452:219-229.
8. de Boer JG, Glickman BW. 1998. The lacI gene as a target for mutation in transgenic rodents and Escherichia coli. Genetics 148:1441-1451.
9. Farabaugh PJ. 1978. Sequence of the lacI gene. Nature 274:765-769.
10. Heinmoller PW, Hill KA, Sommer SS. 2000. High plating density improves Big Blue® system efficiency without loss of sensitivity. Mutat Res 453:97-103.
11. Hill KA, Buettner VL, Glickman BW, Sommer SS. 1999a. Spontaneous mutations in the Big Blue® transgenic system are primarily mouse derived. Mutat Res 436:11-19.
12. Hill KA, Nishino H, Buettner VL, Halangoda A, Li W, Sommer SS. 1999b. The Big Blue® transgenic mouse mutation detection assay: The mutation pattern of sectored mutant plaques. Mutat Res 425:47-54.
13. Hill KA, Buettner VL, Halangoda A, Kunishige M, Moore SR, Longmate J, Scaringe WA, Sommer SS. 2004a. Spontaneous mutation in Big Blue® mice from fetus to old age: Tissue-specific time courses of mutation frequency but similar mutation types. Environ Mol Mutagen 43:110-120.
14. Hill KA, Wang J, Farwell KD, Scaringe WA, Sommer SS. 2004b. Spontaneous multiple mutations show both proximal spacing consistent with chronocoordinate events and alterations with p53-deficiency. Mutat Res 554:223-240.
15. Hill KA, Halangoda A, Heinmoeller PW, Gonzalez K, Chitaphan C, Longmate J, Scaringe WA, Wang JC, Sommer SS. 2005. Tissue-specific time courses of spontaneous mutation frequency and deviations in mutation pattern are observed in middle to late adulthood in Big Blue® mice. Environ Mol Mutagen 45:442-454.
16. Hill KA, Buettner VL, Heidt A, Chen LL, Li W, Gonzalez KD, Wang JC, Scaringe WA, Sommer SS. 2006. Most spontaneous tumors in a mouse model of Li-Fraumeni syndrome do not have a mutator phenotype. Carcinogenesis 27:1860-1866.
17. Jiang T, Glickman BW, de Boer JG. 2001. Protective effect of green tea against benzo[a]pyrene-induced mutations in the liver of Big Blue® transgenic mice. Mutat Res 480-481:147-151.
18. Kohler SW, Provost GS, Kretz PL, Fieck A, Sorge JA, Short JM. 1990. The use of transgenic mice for short-term, in vivo mutagenicity testing. Genet Anal Tech Appl 7:212-218.
19. Kohler SW, Provost GS, Fieck A, Kretz PL, Bullock WO, Putman DL, Sorge JA, Short JM. 1991. Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacI shuttle vector. Environ Mol Mutagen 18:316-321.
20. Kunishige M, Hill KA, Riemer AM, Farwell KD, Halangoda A, Heinmoller E, Moore SR, Turner DM, Sommer SS. 2001. Mutation frequency is reduced in the cerebellum of Big Blue® mice overexpressing a human wild type SOD1 gene. Mutat Res 473:139-149.
21. Lambert IB, Singer TM, Boucher SE, Douglas GR. 2005. Detailed review of transgenic rodent mutation assays. Mutat Res 590:1-280.
22. Liu Q, Thorland EC, Heit JA, Sommer SS. 1997. Overlapping PCR for bidirectional PCR amplification of specific alleles: A rapid onetube method for simultaneously differentiating homozygotes and heterozygotes. Genome Res 7:389-398.
23. Moore SR, Hill KA, Heinmoller PW, Halangoda A, Kunishige M, Buettner VL, Graham KS, Sommer SS. 1999. Spontaneous mutation frequency and pattern in Big Blue® mice fed a vitamin E-supplemented diet. Environ Mol Mutagen 34:195-200.
24. Mukherjee J, Ghosh A, Chaudhuri S. 2006. ENU administration causes genomic instability along with single nucleotide polymorphisms in p53 during gliomagenesis: T11TS administration demonstrated in vivo apoptosis of these genetically altered tumor cells. Cancer Biol Ther 5:156-164.
25. Nishino H, Knoll A, Buettner VL, Frisk CS, Maruta Y, Haavik J, Sommer SS. 1995. p53 wild-type and p53 nullizygous Big Blue® transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain. Oncogene 11:263-270.
26. Nishino H, Buettner VL, Haavik J, Schaid DJ, Sommer SS. 1996a. Spontaneous mutation in Big Blue® transgenic mice: Analysis of age, gender, and tissue type. Environ Mol Mutagen 28:299-312.
27. Nishino H, Buettner VL, Sommer SS. 1996b. Towards validation of the Big Blue® transgenic mouse mutagenesis assay: The mutational spectrum of ex vivo pinpoint mutant plaques. Mutat Res 372:97-105.
28. Ono T, Ikehata H, Nakamura S, Saito Y, Hosoi Y, Takai Y, Yamada S, Onodera J, Yamamoto K. 2000. Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse. Mutat Res 447:165-177.
29. Rogers BJ, Provost GS, Young RR, Putman DL, Short JM. 1995. Intralaboratory optimization and standardization of mutant screening conditions used for a lambda/lacI transgenic mouse mutagenesis assay (I). Mutat Res 327:57-66.
30. Shane BS, de Boer J, Watson DE, Haseman JK, Glickman BW, Tindall KR. 2000a. LacI mutation spectra following benzo[a]pyrene treatment of Big Blue® mice. Carcinogenesis 21:715-725.
31. Shane BS, Smith-Dunn DL, de Boer JG, Glickman BW, Cunningham ML. 2000b. Mutant frequencies and mutation spectra of dimethylnitrosamine (DMN) at the lacI and cII loci in the livers of Big Blue® transgenic mice. Mutat Res 452:197-210.
32. Stratagene. 1992. Big Blue® Transgenic Mouse Mutagen Assay System: Instruction Manual. La Jolla, CA.
33. Stuart GR, Gorelick NJ, Andrews JL, de Boer JG, Glickman BW. 1996. The genetic analysis of lacI mutations in sectored plaques from Big Blue® transgenic mice. Environ Mol Mutagen 28:385-392.
34. Stuart GR, Oda Y, de Boer JG, Glickman BW. 2000a. Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice. Genetics 154:1291-1300.
35. Stuart GR, Thorleifson E, Okochi E, de Boer JG, Ushijima T, Nagao M, Glickman BW. 2000b. Interpretation of mutational spectra from different genes: Analyses of PhIP-induced mutational specificity in the lacI and cII transgenes from colon of Big Blue® rats. Mutat Res 452:101-121.
36. Wang J, Gonzalez KD, Scaringe WA, Tsai K, Liu N, Gu D, Li W, Hill KA, Sommer SS. 2007. Evidence for mutation showers. Proc Natl Acad Sci USA 104:8403-8408.