Towards validation of the Big Blue® transgenic mouse mutagenesis assay: The mutational spectrum of ex vivo pinpoint mutant plaques

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 372, Issue 1, 1996, Pages 97-105

  Nishino, Hiroshi ^a,b   Buettner, Victoria L ^a   Sommer, Steve S ^a,c  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Background mutation; Big Blue; E. coli; Pinpoint

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ESCHERICHIA COLI; GENE SEQUENCE; MOUSE; MUTANT; NONHUMAN; OPERATOR GENE; POINT MUTATION; PRIORITY JOURNAL; SCREENING; SPONTANEOUS MUTATION; TANDEM REPEAT; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; BETA-GALACTOSIDASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTAGENICITY TESTS; MUTATION; RECOMBINANT PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID; REPRESSOR PROTEINS; REPRODUCIBILITY OF RESULTS; SEQUENCE ANALYSIS, DNA;

EID: 0030580233     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00172-8     Document Type: Article

References (17)

1. Cole, J. and T.R. Skopek (1994) Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo. Mutation Res., 304, 33-105.
2. Cooper, D.N. and M. Krawczak (1993) Human Gene Mutation, Bios Scientific Publishers, Oxford, England.
3. Coulondre, C., J.H. Miller, PJ. Farabaugh and W. Gilbert (1978) Molecular basis of base substitution hotspots in E. coli, Nature, 274, 775-780.
4. Farabaugh, P.J. and J.H. Miller (1978) Genetic studies of the lac represser VII: on the molecular nature of spontaneous hotspots in the lacI gene of Escherichia colli, J. Mol. Biol., 26, 847-863.
5. Gordon, A. and J. Halliday (1994) Transgenic systems for in vivo mutational analysis (Provost et al., Mutation Res., 288 (1993) 133-149), Mutation Res., 306, 103-105.
6. Gossen, J.A., WJ.F. deLeeuw, C.H.T. Tan, E.C. Zwarthoff, F. Berends, P.H.M. Lohman, D.L. Knook and J. Vijg (1989) Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo, Proc. Natl. Acad. Sci. USA, 86, 7971-7975.
7. Knöll, A., D.P. Jacobson, H. Nishino, J.M. Short, P.L. Kretz and S.S. Sommer (1996) The growth selectable system for mutation detection in the Big Blue™ lacI transgenic mouse system: What happens to the mutational spectra over time? Mutation Res., in press.
8. Kohler, S.W., G.S. Provost, A. Fieck, P.L. Kretz, W.O. Bullock, J.A. Sorge, D.L. Putman and J.M. Short (1991) Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice, Proc. Natl. Acad. Sci. USA, 88, 7958-7962.
9. LeClerc, J.E., J.R. Christensen, P.V. Tata, R.B. Christensen and C.W. Lawrence (1988) Ultraviolet light induces different spectra lacI sequence changes in vegetative and conjugating cells of Escherichia coli, J. Mol. Biol., 203, 619-633.
10. Mehta, C.R. and N.R. Patel (1983) A network algorithm for performing Fisher's exact test in r × c contingency tables, J. Am. Stat. Assoc., 78, 427-434.
11. Nishino, H., A. Knöll, V.L. Buettner, C.S. Frisk, Y. Maruta, J. Haavik and S.S. Sommer (1995) p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain, Oncogene, 11, 263-270.
12. Provost, G.S., P.L. Kretz, R.T. Hamner, C.D. Matthews, B.J. Rogers, K.S. Lundberg, M.J. Dycaico and J.M. Short (1993) Transgenic systems for in vivo mutation analysis, Mutation Res., 288, 133-149.
13. Schaaper, R.M., B.N. Danforth and B.W. Glickman (1986) Mechanisms of spontaneous mutagenesis: an analysis of the spectrum of spontaneous mutation in the Escherichia coli lacI gene, J. Mol. Biol., 189, 273-284.
14. Schaaper, R.M. and R.L. Dunn (1991) Spontaneous mutation in the Escherichia coli lacI gene, Genetics, 129, 317-326.
15. Skopek, T.R., K.L. Kort and D.R. Marino (1995) Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue™ B6C3F1 mice, Environ. Mol. Mutagen., 26, 9-15.
16. Tao, K.S., C. Urlando and J.A. Heddle (1993) Comparison of somatic mutation in a transgenic versus host locus, Proc. Natl. Acad. Sci. USA, 90, 10681-10685.
17. Yatagai, F. and B.W. Glickman (1990) Specificity of spontaneous mutation in the lacI gene cloned into bacteriophage M13, Mutation Res., 243, 21-28.