Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells

Molecular Cancer Therapeutics

Volumn 8, Issue 2, 2009, Pages 424-432

  Morales, Cristina ^a,d   García, Maria J ^c,e   Ribas, Maria ^a   Miró, Rosa ^a   Muñoz, Mar ^b   Caldas, Carlos ^c   Peinado, Miguel A ^a,b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b Institut de Medicina Predictiva I Personalitzada del Càncer Ctra de Can Ruti   (Spain)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e Centro Nacional de Investigations Oncológicas   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; METHOTREXATE;

ADVANCED CANCER; AMPLICON; ARTICLE; CANCER CELL; CANCER RESISTANCE; CANCER STAGING; COLON CANCER; CONTROLLED STUDY; CYTOGENETICS; DHFR GENE; DRUG REEXPOSURE; EIF3S3 GENE; GENE; GENE AMPLIFICATION; HMSH3 GENE; HUMAN; HUMAN CELL; MLZE GENE; MTBP GENE; MULTIPLE CYCLE TREATMENT; PRIORITY JOURNAL; RAD21 GENE; RASGRF2 GENE; TAF2 GENE; WISP1 GENE;

BASE SEQUENCE; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 5; CHROMOSOMES, HUMAN, PAIR 8; CLONE CELLS; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GENE AMPLIFICATION; GENE DOSAGE; HT29 CELLS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; METHOTREXATE; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 60849083812     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0759     Document Type: Article

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